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ATN-161 trifluoroacetate salt

Catalog No. T10397 CAS 904763-27-5

Synonyms: ATN-161 TFA salt

ATN-161 trifluoroacetate salt (ATN-161 TFA salt) is a novel integrin α5β1 antagonist that inhibits angiogenesis and growth of liver metastases and improves survival in a murine model.

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ATN-161 trifluoroacetate salt Chemical Structure

ATN-161 trifluoroacetate salt, CAS 904763-27-5

Pack Size	Availability	Price/USD
1 mg	In stock	$ 38.00
2 mg	In stock	$ 54.00
5 mg	In stock	$ 89.00
10 mg	In stock	$ 128.00
25 mg	In stock	$ 237.00
50 mg	In stock	$ 397.00
100 mg	In stock	$ 589.00

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Purity: 99.98%

Purity: 98%

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Description	ATN-161 trifluoroacetate salt (ATN-161 TFA salt) is a novel integrin α5β1 antagonist that inhibits angiogenesis and growth of liver metastases and improves survival in a murine model.
In vitro	The co-administration of ATN-161 and 5-FU markedly reduces tumor cell growth more effectively than either treatment alone or the control. Additionally, this combined approach markedly elevates the levels of apoptotic (TUNEL-positive) tumor cells, a result not observed with single-agent treatments. Furthermore, ATN-161 demonstrates a 21% reduction in endothelial cell (EC) numbers after 48 hours compared to controls, highlighting its effectiveness. Importantly, ATN-161 also impedes VEGF-induced endothelial cell migration and capillary formation, although it does not affect their proliferation. It significantly decreases endothelial cell migration towards VEGF in a dose-dependent manner, beginning at 100 nM (P<0.001 vs. VEGF group), showcasing its potential in inhibiting angiogenesis[1][2].
In vivo	Initial tests on α5β1-negative human colon cancer xenografts (HT29) show ATN-161 significantly decreases tumor weight and vessel density [1]. Administering ATN-161 post-laser photocoagulation effectively suppresses choroidal neovascularization (CNV) leakage and new blood vessel formation, achieving results comparable to those with AF564 [2].

Synonyms	ATN-161 TFA salt
Molecular Weight	711.67
Formula	C25H36F3N9O10S
CAS No.	904763-27-5

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: Slightly soluble

References and Literature

1. Stoeltzing O, et al. Inhibition of integrin alpha5beta1 function with a small peptide (ATN-161) plus continuous 5-FU infusion reduces colorectal liver metastases and improves survival in mice. Int J Cancer. 2003 Apr 20;104(4):496-503. 2. Wang W, et al. The antiangiogenic effects of integrin alpha5beta1 inhibitor (ATN-161) in vitro and in vivo. Invest Ophthalmol Vis Sci. 2011 Sep 14;52(10):7213-20.

Related compound libraries

This product is contained In the following compound libraries：

Anti-Cancer Active Compound Library Anti-Cancer Clinical Compound Library Inhibitor Library Anti-Cancer Drug Library Drug Repurposing Compound Library NO PAINS Compound Library Angiogenesis related Compound Library ReFRAME Related Library Bioactive Compounds Library Max Bioactive Compound Library

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Keywords

ATN-161 trifluoroacetate salt 904763-27-5 Cytoskeletal Signaling Integrin ATN 161 trifluoroacetate salt ATN 161 Trifluoroacetate ATN161 trifluoroacetate salt ATN-161 TFA ATN161 inhibit ATN-161 TFA salt ATN-161 ATN 161 Inhibitor ATN-161 Trifluoroacetate ATN161 Trifluoroacetate inhibitor

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