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AR-A 2

Catalog No. T10360 CAS 220051-79-6

Synonyms: AR-A 000002

AR-A 2 is a selective 5-HT1B receptor antagonist, with a high affinity to guinea pig cortex 5HT1B/1D and recombinant guinea pig 5-HT1B receptors (Ki: 0.24 and 0.47 nM) and with 10-fold lower affinity to guinea pig 5-HT1D receptor (Ki: 5 nM).

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AR-A 2, CAS 220051-79-6

Pack Size	Availability	Price/USD
25 mg	6-8 weeks	$ 1,670.00
50 mg	6-8 weeks	$ 2,180.00
100 mg	6-8 weeks	$ 2,800.00

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This compound is a customized synthesis product. We have a strong synthesis team with excellent synthesis technology and capabilities. However, due to various objective factors, there is a low probability that the synthesis will not be successful. If you need to learn more, please feel free to consult us, we will serve you wholeheartedly.

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Description	AR-A 2 is a selective 5-HT1B receptor antagonist, with a high affinity to guinea pig cortex 5HT1B/1D and recombinant guinea pig 5-HT1B receptors (Ki: 0.24 and 0.47 nM) and with 10-fold lower affinity to guinea pig 5-HT1D receptor (Ki: 5 nM).
Targets&IC50	5-HT1B receptor (guinea pig):（EC50）4.5 nM , 5-HT1B/1D receptor (rat cortical): 20 nM , 5-HT1B receptor (guinea pig): 0.47 nM , D2: 330 nM , 5-HT1B/1D (guinea pig cortex):（ki）0.24 nM , 5-HT1A receptor (rat hippocampus): 3070 nM , α1-adrenoceptor: 490 nM , 5-HT2A receptor (rat cortex): 339 nM , 5-HT1D receptor (guinea pig): 5 nM
In vitro	AR-A 2 (AR-A000002) is a selective 5-HT1B receptor antagonist and shows an EC50 of 4.5 nM for the guinea pig 5-HT1B receptor. AR-A 2 also binds to the rat cortical 5HT1B/1D receptor (Ki: 20 nM), rat cortex 5-HT2A receptor (Ki: 339 nM), rat hippocampus 5-HT1A receptor (Ki: 3070 nM). In addition, AR-A 2 also exhibits an affinity for dopamine D2 (Ki: 330 nM) and α1-adrenoceptors (Ki: 490 nM).

Synonyms	AR-A 000002
Molecular Weight	448.6
Formula	C27H36N4O2
CAS No.	220051-79-6

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

References and Literature

1. Ahlgren C, et al. In vitro characterization of AR-A000002, a novel 5-hydroxytryptamine(1B) autoreceptor antagonist. Eur J Pharmacol. 2004 Sep 19;499(1-2):67-75.

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Keywords

AR-A 2 220051-79-6 Others ARA 2 AR-A-000002 AR-A 000002 AR-A000002 AR A 2 inhibitor inhibit

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