Angiogenesis HER AG1478


Catalog No. T2047   CAS 153436-53-4
Synonyms: AG 1478, AG-1478, NSC 693255, Tyrphostin AG-1478

AG-1478 (Tyrphostin AG-1478) is a selective EGFR inhibitor.

AG1478, CAS 153436-53-4
Pack Size Availability Price/USD Quantity
5 mg In stock 50.00
10 mg In stock 68.00
25 mg In stock 127.00
50 mg In stock 230.00
100 mg In stock 320.00
200 mg Inquiry 416.00
1 mL * 10 mM (in DMSO) In stock 54.00
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Purity 98.00%
Purity 99.71%
Biological Description
Chemical Properties
Storage & Solubility Information
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Description AG-1478 (Tyrphostin AG-1478) is a selective EGFR inhibitor.
Targets&IC50 EGFR : ic50 3nM ,   HER2 : ic50 >100μM ,   PDGFR : ic50 >100μM
Cell Research
Cells are exposed to different concentrations of AG-1478 for 72 hours in 96-well plates. The effects of AG-1478 on cell growth are examined using an Alamar Blue assay. A 20-μL aliquot of Alamar Blue is added to each well, and its absorbance is determined using a Spectromax Scanning Micro plate Reader. The effects of AG-1478 are expressed as percentage of growth inhibition using untreated cells as the control (0% inhibition). Cellular DNA synthesis is determined using a [3H]thymidine incorporation assay. (Only for Reference)
Cell lines: U87MG
Animal Research
Animal Model: FeBALB/c nu/nu mice inoculated s.c. with A431 or U87MG.Δ2-7 tumor cells
Synonyms AG 1478 , AG-1478 , NSC 693255 , Tyrphostin AG-1478
Purity 98.00%
Molecular Weight 315.75
Formula C16H14ClN3O2
CAS No. 153436-53-4


0-4℃ for short term (days to weeks), or -20℃ for long term (months).

Solubility Information

DMSO: 24 mg/mL (76 mM)

Ethanol: 11 mg/mL (34.8 mM)

Water: <1 mg/mL

( < 1 mg/ml refers to the product slightly soluble or insoluble )

Solution 1

15% Captisol: 30 mg/mL


References and Literature
1. Levitzki A, et al. Science, 1995, 267(5205), 1782-1788. 2. Han Y, et al. Cancer Res, 1996, 56(17), 3859-3861. 3. Eguchi S, et al. J Biol Chem, 1998, 273(15), 8890-8896. 4. Johns TG, et al. Proc Natl Acad Sci U S A, 2003, 100(26), 15871-15876. 5. Lee FT, et al. Clin Cancer Res, 2005, 11(19 Pt 2), 7080s-7086s. 6. Akhtar S, et al. Cationic Polyamidoamine Dendrimers as Modulators of EGFR Signaling In Vitro and In Vivo. PLoS One. 2015 Jul 13;10(7):e0132215. 7. Li W, et al. EGFR Inhibition Blocks Palmitic Acid-induced inflammation in cardiomyocytes and Prevents Hyperlipidemia-induced Cardiac Injury in Mice. Sci Rep. 2016 Apr 18;6:24580. 8. Li S T, Young T H, Huang T W. Poly (ethylene-co-vinyl alcohol) is a suitable substrate for human olfactory neuroepithelial cell differentiation in vitro through a defined regulatory pathway[J]. Acta biomaterialia. 2018 Mar 1;68:204-213.

Related compound libraries

This product is contained In the following compound libraries:
Bioactive Compound Library Inhibitor Library Anti-cancer Compound Library Clinical Compound Library Anti-infection Compound Library Tyrosine kinase inhibitor library Anti-virus Compound Library Cytokine Inhibitor Library Kinase Inhibitor Library Anti-cancer Clinical Compound Library Angiogenesis related Compound Library Preclinical Compound Library JAK STAT Compound Library

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