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AC1903

Catalog No. T8528 CAS 831234-13-0

AC1903 is a specific inhibitor of TRPC5 channel, and has been shown to suppress severe proteinuria and prevent podocyte loss.

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AC1903, CAS 831234-13-0

Pack Size	Availability	Price/USD
5 mg	In stock	$ 53.00
10 mg	In stock	$ 91.00
25 mg	In stock	$ 198.00
50 mg	In stock	$ 344.00
1 mL * 10 mM (in DMSO)	In stock	$ 59.00

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Purity: 98.33%

Biological Description

Chemical Properties

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Description	AC1903 is a specific inhibitor of TRPC5 channel, and has been shown to suppress severe proteinuria and prevent podocyte loss.
Targets&IC50	TRPC5 current (HEK-293 cells):14.7 μM (IC50)
In vivo	AC1903, that specifically blocks TRPC5 channel activity in glomeruli of proteinuric rats.?Chronic administration of AC1903 suppressed severe proteinuria and prevented podocyte loss in a transgenic rat model of FSGS.AC1903 also provided therapeutic benefit in a rat model of hypertensive proteinuric kidney disease.?TRPC5 activity drives disease and that TRPC5 inhibitors may be valuable for the treatment of progressive kidney diseases[1].
Animal Research	Twice-daily intraperitoneal injections of AC1903 (50 mg/kg) for 7 days suppressed severe proteinuria in AT1R Tg rats (Advanced)[1]

Molecular Weight	303.36
Formula	C19H17N3O
CAS No.	831234-13-0

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 32.5 mg/mL (107.13 mM)

References and Literature

1. Yiming Zhou, et al. A small-molecule inhibitor of TRPC5 ion channels suppresses progressive kidney disease in animal models. Science 2. Sharma S H , Pablo J L , Montesinos M S , et al. Design, synthesis and characterization of novel N-heterocyclic-1-benzyl-1H-benzo[d]imidazole-2-amines as selective TRPC5 inhibitors leading to the identification of the selective compound, AC1903[J]. Bioorganic & Medicinal Chemistry Letters, 2018.

Related compound libraries

This product is contained In the following compound libraries：

Kinase Inhibitor Library Inhibitor Library Neuronal Signaling Compound Library NO PAINS Compound Library Ion Channel Inhibitor Library Anti-Cancer Compound Library

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

AC1903 831234-13-0 Membrane transporter/Ion channel TRP/TRPV Channel Inhibitor glomerulosclerosis proteinuria inhibit TRP Channel ros focal segmental Transient receptor potential channels AC 1903 FSGS kidney disease podocyte loss AC-1903 HEK-293 inhibitor

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