Powder: -20°C for 3 years | In solvent: -80°C for 1 year
9-ING-41 is a glycogen synthase kinase-3 inhibitor.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 45.00 | |
2 mg | In stock | $ 64.00 | |
5 mg | In stock | $ 101.00 | |
10 mg | In stock | $ 166.00 | |
25 mg | In stock | $ 343.00 | |
50 mg | In stock | $ 497.00 | |
100 mg | In stock | $ 742.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 118.00 |
Description | 9-ING-41 is a glycogen synthase kinase-3 inhibitor. |
Targets&IC50 | GSK-3β:0.71 μM (IC50) |
In vitro | 9-ING-41 (2, 4 μM; 48 hours) decreases neuroblastoma cell viability induces apoptosis[2]. 9-ING-41 (1, 2 μM; 24 hours) is a potent cell cycle-blocking agent for lymphoma cells[2]. 9-ING-41 (0.1-1 μM) inhibits GSK-3 leading to a decreased expression of the NF-κB target XIAP and significant apoptosis in neuroblastoma cells as shown by PARP cleavage, an apoptosis marker[1]. 9-ING-41 (0.5, 1.0, 1.5, 2.0 μM) inhibits the proliferation rate of all TCL and MCL lines with concentrations as low as 1.0 mM[2]. |
In vivo | In a mouse model of MCL, 9-ING-41 (40 mg/kg/every other day; for 17 days) has single-agent antitumor activity [2]. |
Molecular Weight | 404.35 |
Formula | C22H13FN2O5 |
CAS No. | 1034895-42-5 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 97 mg/mL (239.89 mM), Sonification is recommended.
You can also refer to dose conversion for different animals. More
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9-ING-41 1034895-42-5 Apoptosis Autophagy PI3K/Akt/mTOR signaling Stem Cells GSK-3 cycle cell inhibit 9ING41 Inhibitor Glycogen synthase kinase 3 9 ING 41 arrest Glycogen synthase kinase-3 anticancer GSK-3β activity inhibitor