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740 Y-P(TFA)(1236188-16-1 free base)

Catalog No. TQ0003L   CAS TQ0003L
Synonyms: PDGFR 740Y-P(TFA), 740 Y-P(TFA), 740YPDGFR(TFA)

740 Y-P(TFA)(1236188-16-1 free base) (740YPDGFR(TFA)) is a potent and cell-permeable activator of PI3K.

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740 Y-P(TFA)(1236188-16-1 free base) Chemical Structure
740 Y-P(TFA)(1236188-16-1 free base), CAS TQ0003L
Pack Size Availability Price/USD Quantity
1 mg Inquiry $ 96.00
5 mg Inquiry $ 264.00
10 mg Inquiry $ 369.00
25 mg Inquiry $ 620.00
50 mg Inquiry $ 944.00
100 mg Inquiry $ 1,415.00
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Biological Description
Chemical Properties
Storage & Solubility Information
Description 740 Y-P(TFA)(1236188-16-1 free base) (740YPDGFR(TFA)) is a potent and cell-permeable activator of PI3K.
In vitro 740 Y-P is a synthetic biotinylated peptide. 740 Y-P stimulates mitogenesis at the lowest concentration tested (1 mg/mL). The peptide stimulates mitogenesis in both the presence and absence of serum (0.5%) and in the former instance, a maximal response observed at 50 mg/mL. 740Y-P peptide to stimulate mitogenesis is highly specific and not a general feature of a cell-permeable SH2 domain-binding peptide [1]. 740Y-P is as effective as a growth factor (FGF2) at promoting neuronal cell survival via the established PI 3-kinase-Akt survival cascade. Stimulation of neuronal cell survival by the PDGFR740Y-P peptide is dose-dependent and does not require insulin[2].
Synonyms PDGFR 740Y-P(TFA), 740 Y-P(TFA), 740YPDGFR(TFA)
Molecular Weight 3384.73
Formula C143H223F3N43O41PS3
CAS No. TQ0003L

Storage

keep away from moisture

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

TargetMolReferences and Literature

1. Derossi D, et al. Stimulation of mitogenesis by a cell-permeable PI 3-kinase binding peptide. Biochem Biophys Res Commun. 1998 Oct 9;251(1):148-52. 2. Williams EJ, Evidence for and against a pivotal role of PI 3-kinase in a neuronal cell survival pathway. Mol Cell Neurosci. 1999 Apr;13(4):272-80.

TargetMolCitations

1. Zhang, Chaochao, et al. Mechanisms Involved in the Anti-Tumor Effects of Toosendanin in Glioma Cells. Cancer Cell International. 2021, 21(1): 1-13. 2. Zhang C, Gao H, Liu Z, et al. Mechanisms involved in the anti-tumor efects of Toosendanin in glioma cells. Cancer Cell International. 2021, 21(1): 1-13

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Keywords

740 Y-P(TFA)(1236188-16-1 free base) TQ0003L PI3K/Akt/mTOR signaling PI3K PDGFR 740Y-P(TFA) 740 Y P(TFA)(1236188 16 1 free base) 740 Y-P(TFA) 740 YP(TFA)(1236188161 free base) 740YPDGFR(TFA) inhibitor inhibit

 

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