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740 Y-P(TFA)(1236188-16-1 free base)

Catalog No. TQ0003L CAS TQ0003L

Synonyms: PDGFR 740Y-P(TFA), 740 Y-P(TFA), 740YPDGFR(TFA)

740 Y-P(TFA)(1236188-16-1 free base) (740YPDGFR(TFA)) is a potent and cell-permeable activator of PI3K.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.

740 Y-P(TFA)(1236188-16-1 free base) Chemical Structure

740 Y-P(TFA)(1236188-16-1 free base), CAS TQ0003L

Pack Size	Availability	Price/USD
1 mg	Inquiry	$ 96.00
5 mg	Inquiry	$ 264.00
10 mg	Inquiry	$ 369.00
25 mg	Inquiry	$ 620.00
50 mg	Inquiry	$ 944.00
100 mg	Inquiry	$ 1,415.00

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Biological Description

Chemical Properties

Storage & Solubility Information

Description

740 Y-P(TFA)(1236188-16-1 free base) (740YPDGFR(TFA)) is a potent and cell-permeable activator of PI3K.

In vitro

740 Y-P is a synthetic biotinylated peptide. 740 Y-P stimulates mitogenesis at the lowest concentration tested (1 mg/mL). The peptide stimulates mitogenesis in both the presence and absence of serum (0.5%) and in the former instance, a maximal response observed at 50 mg/mL. 740Y-P peptide to stimulate mitogenesis is highly specific and not a general feature of a cell-permeable SH2 domain-binding peptide [1]. 740Y-P is as effective as a growth factor (FGF2) at promoting neuronal cell survival via the established PI 3-kinase-Akt survival cascade. Stimulation of neuronal cell survival by the PDGFR740Y-P peptide is dose-dependent and does not require insulin[2].

Synonyms	PDGFR 740Y-P(TFA), 740 Y-P(TFA), 740YPDGFR(TFA)
Molecular Weight	3384.73
Formula	C143H223F3N43O41PS3
CAS No.	TQ0003L

Storage

keep away from moisture

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

References and Literature

1. Derossi D, et al. Stimulation of mitogenesis by a cell-permeable PI 3-kinase binding peptide. Biochem Biophys Res Commun. 1998 Oct 9;251(1):148-52. 2. Williams EJ, Evidence for and against a pivotal role of PI 3-kinase in a neuronal cell survival pathway. Mol Cell Neurosci. 1999 Apr;13(4):272-80.

Citations

1. Zhang, Chaochao, et al. Mechanisms Involved in the Anti-Tumor Effects of Toosendanin in Glioma Cells. Cancer Cell International. 2021, 21(1): 1-13. 2. Zhang C, Gao H, Liu Z, et al. Mechanisms involved in the anti-tumor efects of Toosendanin in glioma cells. Cancer Cell International. 2021, 21(1): 1-13

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Dehydroglyasperin D GSK2292767 FA PIK-294 PARP/PI3K-IN-1 PI3K/Akt/mTOR-IN-2 Zeylenone TGX-221 iMDK

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Keywords

740 Y-P(TFA)(1236188-16-1 free base) TQ0003L PI3K/Akt/mTOR signaling PI3K PDGFR 740Y-P(TFA) 740 Y P(TFA)(1236188 16 1 free base) 740 Y-P(TFA) 740 YP(TFA)(1236188161 free base) 740YPDGFR(TFA) inhibitor inhibit

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