Powder: -20°C for 3 years | In solvent: -80°C for 1 year
5a-Pregnane-3,20-dione is a biologically active 5-alpha-reduced metabolite of plasma progesterone
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
100 mg | In stock | $ 39.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 39.00 |
Description | 5a-Pregnane-3,20-dione is a biologically active 5-alpha-reduced metabolite of plasma progesterone |
In vitro | the endogenous progesterone metabolite,5a-Pregnane-3,20-dione, may be involved in promoting breast neoplasia and metastasis by affecting adhesion and cytoskeletal molecules. |
Cell Research | MCF-7 cells were grown without or with 5a-Pregnane-3,20-dione (10(-9)-10(-5) M), and the effects on cell and nuclear morphology, adhesion plaques, vinculin and actin expression, actin polymerization, and microfilament distribution were examined by immunohistochemistry, morphometry (using confocal microscopy and digital computer imaging analysis), and Western blotting.?Treatment of cells with 10(-9)-10(-6) M 5a-Pregnane-3,20-dione resulted in dose-dependent decreases in cell area, cell-to-cell contacts, and attachment to the substratum, and increases in variation in nuclear area.?These changes in the 5alphaP-treated cells were accompanied by decreases in vinculin-containing adhesion plaques, vinculin expression, polymerized actin stress fibers, and decreases in insoluble and increases in soluble actin fractions. |
Molecular Weight | 316.48 |
Formula | C21H32O2 |
CAS No. | 566-65-4 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 5 mg/mL (15.80 mM), sonification/heating is recommended.
You can also refer to dose conversion for different animals. More
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5a-Pregnane-3,20-dione 566-65-4 Metabolism Endogenous Metabolite Inhibitor inhibit 5aPregnane3,20dione 5a Pregnane 3,20 dione inhibitor