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4-Hydroxypropranolol hydrochloride

Catalog No. T10150 CAS 14133-90-5

Synonyms: (±)-4-hydroxy Propranolol hydrochloride

4-Hydroxypropranolol hydrochloride is an active metabolite of Propranolol, with a potency comparable to Propranolol. It inhibits β1- and β2-adrenergic receptors (pA2s: 8.24 and 8.26).

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4-Hydroxypropranolol hydrochloride Chemical Structure

4-Hydroxypropranolol hydrochloride, CAS 14133-90-5

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Biological Description

Chemical Properties

Storage & Solubility Information

Description

4-Hydroxypropranolol hydrochloride is an active metabolite of Propranolol, with a potency comparable to Propranolol. It inhibits β1- and β2-adrenergic receptors (pA2s: 8.24 and 8.26).

Synonyms	(±)-4-hydroxy Propranolol hydrochloride
Molecular Weight	311.8
Formula	C16H22ClNO3
CAS No.	14133-90-5

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

References and Literature

1. Fitzgerald JD, et al. Pharmacology of 4-hydroxypropranolol, a metabolite of propranolol. Br J Pharmacol. 1971 Sep;43(1):222-35. 2. Nelson WL, et al. The 3,4-catechol derivative of propranolol, a minor dihydroxylated metabolite. J Med Chem. 1984 Jul;27(7):857-61. 3. Ivan Tong Mak, et al. Potent Antioxidant Properties of 4-Hydroxyl-propranolol. Journal of Pharmacology and Experimental Therapeutics. 2004, 308(1):85-90.

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Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

4-Hydroxypropranolol hydrochloride 14133-90-5 Others 4-hydroxy Propranolol Hydrochloride 4Hydroxypropranolol hydrochloride 4-Hydroxypropranolol Hydrochloride 4 Hydroxypropranolol hydrochloride (±)-4-hydroxy Propranolol hydrochloride inhibitor inhibit

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