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2-Methylcitric acid trisodium

Catalog No. T10076L CAS 117041-96-0

Synonyms: Methylcitric acid trisodium

2-Methylcitric acid trisodium (Methylcitric acid) is an endogenous metabolite in the 2-methylcitric acid cycle. It accumulates in methylmalonic and propionic acidemias.

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2-Methylcitric acid trisodium Chemical Structure

2-Methylcitric acid trisodium, CAS 117041-96-0

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Biological Description

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Description

2-Methylcitric acid trisodium (Methylcitric acid) is an endogenous metabolite in the 2-methylcitric acid cycle. It accumulates in methylmalonic and propionic acidemias.

In vitro

2-Methylcitric acid impairs glutamate metabolism and induces permeability transition in brain mitochondria. It inhibits glutamate dehydrogenase (GDH) activity at concentrations as low as 0.5 mM. 2-Methylcitric acid (1-3 mM; 150 seconds) provokes a significant decrease in mitochondrial membrane potential and induced swelling in Ca2+-loaded mitochondria supported by different substrates. 2-Methylcitric acid behaves as a potent inhibitor of glutamate oxidation by inhibiting glutamate dehydrogenase activity and as a permeability transition inducer, disturbing mitochondrial energy homeostasis. 2-Methylcitric acid does not significantly impair mitochondrial glutamate transport. 2-Methylcitric acid does not significantly impair glutamate mitochondrial transport in liver mitochondria.

Synonyms	Methylcitric acid trisodium
Molecular Weight	229.14
Formula	C7H10NaO7
CAS No.	117041-96-0

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

References and Literature

1. Palacios S, et al. Propionyl Coenzyme A Is a Common Intermediate in the 1,2-Propanediol and Propionate Catabolic Pathways Needed for Expression of the prpBCDE Operon during Growth of Salmonella enterica on 1,2-Propanediol. J Bacteriol. 2003 May;185(9):2802-10.

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Keywords

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