Powder: -20°C for 3 years | In solvent: -80°C for 1 year
2,6-Dichloro-N-(2-(cyclopropanecarboxamido)pyridin-4-yl)benzamide (GDC046), a potent lead analog, has good kinase selectivity, physicochemical properties and pharmacokinetic profile.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 56.00 | |
5 mg | In stock | $ 122.00 | |
10 mg | In stock | $ 197.00 | |
25 mg | In stock | $ 455.00 | |
50 mg | In stock | $ 657.00 | |
100 mg | In stock | $ 918.00 |
Description | 2,6-Dichloro-N-(2-(cyclopropanecarboxamido)pyridin-4-yl)benzamide (GDC046), a potent lead analog, has good kinase selectivity, physicochemical properties and pharmacokinetic profile. |
Targets&IC50 | JAK2:0.7 nM (Ki), JAK1:0.7 nM (Ki), Tyk2:4.8 nM (Ki), JAK3:0.4 nM (Ki) |
Synonyms | GDC046 |
Molecular Weight | 350.2 |
Formula | C16H13Cl2N3O2 |
CAS No. | 1258292-64-6 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 3.33 mg/mL (9.52 mM)
You can also refer to dose conversion for different animals. More
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2,6-Dichloro-N-(2-(cyclopropanecarboxamido)pyridin-4-yl)benzamide 1258292-64-6 Angiogenesis Chromatin/Epigenetic JAK/STAT signaling Others Stem Cells JAK 2,6 Dichloro N (2 (cyclopropanecarboxamido)pyridin 4 yl)benzamide JAK1 GDC046 IBD GDC-046 GDC 046 2,6DichloroN(2(cyclopropanecarboxamido)pyridin4yl)benzamide inflammatory TYK2 bowel Janus kinase Inhibitor inhibit IL-12 diseases JAK3 JAK2 IL-23 inhibitor