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2',3'-cGAMP sodium

Catalog No. T10065L CAS 2734858-36-5

Synonyms: 2'-3'-cyclic GMP-AMP sodium

2',3'-cGAMP sodium (2'-3'-cyclic GMP-AMP sodium), a cGAMP synthase (cGAS) affecting cytoplasmic DNA production as a second messenger, is a transmembrane bridging protein that is a key component of the cellular innate immune response to pathogenic cytoplasmic DNA.

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2',3'-cGAMP sodium, CAS 2734858-36-5

Pack Size	Availability	Price/USD
1 mg	In stock	$ 247.00
5 mg	In stock	$ 572.00
10 mg	In stock	$ 987.00
25 mg	In stock	$ 1,480.00
50 mg	In stock	Inquiry

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Purity: 99.84%

Purity: 99.71%

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Storage & Solubility Information

Description	2',3'-cGAMP sodium (2'-3'-cyclic GMP-AMP sodium), a cGAMP synthase (cGAS) affecting cytoplasmic DNA production as a second messenger, is a transmembrane bridging protein that is a key component of the cellular innate immune response to pathogenic cytoplasmic DNA.
In vitro	2′3′-cGAMP sodium is capable of enhancing the proinflammatory activation of cultured Wild-type (WT) macrophages. Unlike in macrophages (BMDM), 2′3′-cGAMP sodium treatment displayed anti-inflammatory effects in both WT primary mouse hepatocytes and differentiated 3T3-L1 adipocytes. Specifically, LPS-induced JNK p46 and NF-κB p65 phosphorylation states and IL-1β and TNFα mRNAs in 2′3′-cGAMP sodium -treated WT primary mouse hepatocytes were significantly lower than their respective levels in control-treated hepatocytes. In 3T3-L1 adipocytes, the anti-inflammatory effect of 2′3′-cGAMP sodium was even more pronounced. In particular, LPS-induced JNK p46 phosphorylation states in 2′3′-cGAMP sodium -treated adipocytes were markedly lower than in control-treated adipocytes, and were comparable with JNK p46 phosphorylation states in 2′3′-cGAMP sodium -treated adipocytes in the absence of LPS induction.[2]
In vivo	At 7 days after tumor cell inoculation, the mice were treated with zebularine alone, 2’,3’-cGAMP sodium alone, or the combination of both. A final concentration of 2.5 mg/mL zebularine was added to drinking water for 10 days until the mice were collected for conducting further experiments. A total of 100 μL of 10μg 2’,3’-cGAMP sodium in PBS at the indicated concentrations was injected into the site next to tumor. 2’,3’-cGAMP sodium treatment was repeated three times with 4-day intervals. This study unveils the role of zebularine in sensitizing the cGAS-STING pathway to promote anti-tumor immunity.[4]

Synonyms	2'-3'-cyclic GMP-AMP sodium
Molecular Weight	718.37
Formula	C20H22N10Na2O13P2
CAS No.	2734858-36-5

Storage

store at low temperature,keep away from direct sunlight

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

H2O: 45.0 mg/mL (62.6 mM), Sonification is recommended.

DMSO: 0.9 mg/mL, Sonification is recommended.

References and Literature

1. Zhang X, et al. Cyclic GMP-AMP containing mixed phosphodiester linkages is an endogenous high-affinity ligand for STING. Mol Cell. 2013 Jul 25;51(2):226-35. 2. Guo X, et al. Cyclic GMP-AMP Ameliorates Diet-induced Metabolic Dysregulation and Regulates Proinflammatory Responses Distinctly from STING Activation. Sci Rep. 2017;7(1):6355. 3. Su M, et al. Second messenger 2'3'-cyclic GMP-AMP (2'3'-cGAMP): Synthesis, transmission, and degradation. Biochem Pharmacol. 2022;198:114934. 4. Lai J, et al. Zebularine elevates STING expression and enhances cGAMP cancer immunotherapy in mice. Mol Ther. 2021;29(5):1758-1771.

Related compound libraries

This product is contained In the following compound libraries：

Rare Natural Product Library

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Related compounds with same targets

Anti-inflammatory agent 65 BI 7446 STING-IN-2 Cridanimod CCCP MSA-2 STING activator Compound 53 SR-717

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Keywords

2',3'-cGAMP sodium 2734858-36-5 Immunology/Inflammation STING cGAS 2'-3'-cyclic GMP-AMP sodium inhibitor inhibit

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