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oxidation-reduction Antioxidant 1,5-Dicaffeoylquinic acid

1,5-Dicaffeoylquinic acid

Catalog No. T6S1529   CAS 30964-13-7
Synonyms: Cynarine
Purity 99.74% Datasheet

1,5-Dicaffeoylquinic acid has neuroprotective, and antioxidant effects, it can inhibition of GSK3β as well as the modulation of Bcl-2/Bax.

1,5-Dicaffeoylquinic acid, CAS 30964-13-7
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10 mg In stock 165.00
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Biological Description
Chemical Properties
Storage & Solubility Information
Description 1,5-Dicaffeoylquinic acid has neuroprotective, and antioxidant effects, it can inhibition of GSK3β as well as the modulation of Bcl-2/Bax.
Targets&IC50
Kinase Assay The processing of an in vitro model of ischemia/reperfusion was described previously. The cultures were washed three times with deoxygenated glucose-free DMEM and placed into an anaerobic chamber with an atmosphere of 10% H2, 85% N2, and 5% CO2 for 4 h. Then the glucose-free DMEM was replaced with complete medium, and the culture plates were maintained at 37 C in a humidified 5% CO2-containing atmosphere for an additional 20 h. As a pretreatment, different concentrations of 1, 5-diCQA were added to the media before OGD for 2 h[1].
Synonyms Cynarine
Purity 99.74%
Appearance solid
Molecular Weight 516.45
Formula C25H24O12
CAS No. 30964-13-7

Storage

-20℃ 3 years powder

-80℃ 2 years in solvent

Solubility Information

DMSO: 23 mg/mL (44.53 mM)

( < 1 mg/ml refers to the product slightly soluble or insoluble )

Citations

References and Literature
1. Cao X, et al. 1, 5-Dicaffeoylquinic acid-mediated glutathione synthesis through activation of Nrf2 protects against OGD/reperfusion-induced oxidative stress in astrocytes.Brain Res. 2010 Aug 6;1347:142-8 2. Xia N , Pautz A , Wollscheid U , et al. Artichoke, Cynarin and Cyanidin Downregulate the Expression of Inducible Nitric Oxide Synthase in Human Coronary Smooth Muscle Cells[J]. Molecules, 2014, 19(3):3654-3668. 3. Topal M, et al. Antioxidant, antiradical, and anticholinergic properties of cynarin purified from the Illyrian thistle (Onopordum illyricum L.). J Enzyme Inhib Med Chem. 2016;31(2):266-75.

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