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CPT (R)-Etomoxir sodium salt

(R)-Etomoxir sodium salt

Catalog No. T4535   CAS 828934-41-4
Synonyms: Etomoxir, Na salt, (+)-Etomoxir sodium salt
Purity 99.82% Datasheet

(R)-Etomoxir sodium salt is R-form of Etomoxir. Etomoxir is a potent inhibitor of carnitine palmitoyltransferase-I (CPT-1).

(R)-Etomoxir sodium salt, CAS 828934-41-4
Pack Size Availability Price/USD Quantity
2 mg In stock 50.00
5 mg In stock 71.00
10 mg In stock 128.00
25 mg In stock 270.00
50 mg In stock 486.00
100 mg In stock 680.00
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Biological Description
Chemical Properties
Storage & Solubility Information
Description (R)-Etomoxir sodium salt is R-form of Etomoxir. Etomoxir is a potent inhibitor of carnitine palmitoyltransferase-I (CPT-1).
Targets&IC50
In vivo P53 interacts directly with Bax, which is inhibited by Etomoxir, further confirming the direct interaction of P53 and Bax and the involvement of FAO-mediated mitochondrial ROS generation in db/db mice[3]. Rats are injected daily with Etomoxir, a specific CPT-I inhibitor, for 8 days at 20 mg/kg of body mass. Etomoxir-treated rats display a 44% reduced cardiac CPT-I activity. The treatment of Lewis rats for 8 days with 20 mg/kg Etomoxir does not alter blood glucose, which is in line with comparable etomoxir-feeding studies. Similarly, Etomoxir feeding does not affect general growth characteristics such as gain in body mass, nor does it affect hindlimb muscle mass. However, heart mass and liver mass are both significantly increased by 11% in Etomoxir-treated rats [4].
Synonyms Etomoxir, Na salt, (+)-Etomoxir sodium salt
Purity 99.43%
Appearance solid
Molecular Weight 320.74
Formula C15H18ClO4.Na
CAS No. 828934-41-4

Storage

-20℃ 3 years powder

-80℃ 2 years in solvent

Solubility Information

DMSO: 199.5 mM

water: 15.59mM

( < 1 mg/ml refers to the product slightly soluble or insoluble )

Citations

References and Literature
1. Rupp H, et al. The use of partial fatty acid oxidation inhibitors for metabolic therapy of angina pectoris and heart failure. Herz. 2002 Nov;27(7):621-36. 2. Xu FY, et al. Etomoxir mediates differential metabolic channeling of fatty acid and glycerol precursors into cardiolipin in H9c2 cells. J Lipid Res. 2003 Feb;44(2):415-23. 3. Li J, et al. FFA-ROS-P53-mediated mitochondrial apoptosis contributes to reduction of osteoblastogenesis and bone mass in type 2 diabetes mellitus. Sci Rep. 2015 Jul 31;5:12724. 4. Luiken JJ, et al. Etomoxir-induced partial carnitine palmitoyltransferase-I (CPT-I) inhibition in vivo does not alter cardiac long-chain fatty acid uptake and oxidation rates. Biochem J. 2009 Apr 15;419(2):447-55. 5. O'Connor RS, et al. The CPT1a inhibitor, etomoxir induces severe oxidative stress at commonly used concentrations. Sci Rep. 2018 Apr 19;8(1):6289.

Related Compound Libraries

This product is contained In the following compound libraries:
Bioactive Compound Library Epigenetics Compound Library

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(R)-Etomoxir sodium salt

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