Powder: -20°C for 3 years | In solvent: -80°C for 1 year
β3-AR agonist 1 is a highly selective, and orally available agonist of β3-adrenergic receptor (EC50: 18 nM), being inactive to β1-, β2-, and α1A-AR (β1/β3, β2/β3, and α1A/β3<556-fold).
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
25 mg | 8-10 weeks | $ 1,970.00 | |
50 mg | 8-10 weeks | $ 2,580.00 | |
100 mg | 8-10 weeks | $ 3,400.00 |
Description | β3-AR agonist 1 is a highly selective, and orally available agonist of β3-adrenergic receptor (EC50: 18 nM), being inactive to β1-, β2-, and α1A-AR (β1/β3, β2/β3, and α1A/β3>556-fold). |
Targets&IC50 | β3-AR:(EC50)18 nM |
In vivo | In marmoset urinary bladder smooth muscle, β3-AR agonist 1 (compound 15) has dose-dependent β3-AR-mediated responses. It has desirable metabolic stability and pharmacokinetic profile (Cmax and AUC), and do not obviously affect heart rate or mean blood pressure when administered intravenously (3 mg/kg) to anesthetized rats. |
Molecular Weight | 444.55 |
Formula | C22H28N4O4S |
CAS No. | 1283125-73-4 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
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β3-AR agonist 1 1283125-73-4 Others β3 AR agonist 1 β3AR agonist 1 b3-AR agonist 1 beta3-AR agonist 1 inhibitor inhibit