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(E)-Cardamonin

Catalog No. T2994 CAS 19309-14-9

Synonyms: Alpinetin chalcone, Cardamomin, Cardamonin, (E)-Cardamoni

(E)-Cardamonin (Alpinetin chalcone) is a chalconoid that has been isolated from several plants including Alpinia katsumadai and Alpinia conchigera. It is a novel antagonist of hTRPA1 cation channel with an IC50 of 454 nM. It has received growing attention from the scientific community due to the expectations toward its benefits to human health.

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(E)-Cardamonin, CAS 19309-14-9

Pack Size	Availability	Price/USD
10 mg	In stock	$ 30.00
25 mg	In stock	$ 55.00
50 mg	In stock	$ 79.00
100 mg	In stock	$ 117.00
500 mg	In stock	$ 283.00
1 mL * 10 mM (in DMSO)	In stock	$ 34.00

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Purity: 99.84%

Purity: 98.08%

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Chemical Properties

Storage & Solubility Information

Description	(E)-Cardamonin (Alpinetin chalcone) is a chalconoid that has been isolated from several plants including Alpinia katsumadai and Alpinia conchigera. It is a novel antagonist of hTRPA1 cation channel with an IC50 of 454 nM. It has received growing attention from the scientific community due to the expectations toward its benefits to human health.
Targets&IC50	TRPA1 (human):454 nM
In vitro	Cardamonin selectively blocksTRPA1 activation (IC50=454 nM) while does not interact with TRPV1 nor TRPV4 channel. Docking analysis of cardamonin demonstrates a compatible interaction with A-967079-binding site of TRPA1. Cardamonin does not significantly reduce HEK293 cell viability, nor does it impair cardiomyocyte constriction[1]. Cardamonin suppresses the expression of Tgase-2, cyclooxygenase-2 (COX-2), and p65 (nuclear factor-κB) in a concentration-dependent manner, and restores the expression of IκB in MG63 and Raw264.7 cells[2].
In vivo	Cardamonin (3-30 mg/kg, orally administered) significantly inhibits PBQ-induced writhing. CDN also produces a significant, dose-dependent increase in the withdrawal response latencies in carrageenan-induced hyperalgesia[2].
Cell Research	HEK293 cells are treated with cardamonin (0-90 μM). The cells treated in the absence of the test compound are the negative control. After incubated for 24 h, Cell Titer-Glo reagent is added to the cells and Luminescence is acquired on the plate reader[1].

Synonyms	Alpinetin chalcone, Cardamomin, Cardamonin, (E)-Cardamoni
Molecular Weight	270.28
Formula	C16H14O4
CAS No.	19309-14-9

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 27 mg/mL(100 mM)

References and Literature

1. Wang S, et al. Cardamonin, a Novel Antagonist of hTRPA1 Cation Channel, Reveals Therapeutic Mechanism of Pathological Pain. Molecules. 2016 Aug 29;21(9). pii: E1145. 2. Park MK, et al. Novel anti-nociceptive effects of cardamonin via blocking expression of cyclooxygenase-2 andtransglutaminase-2. Pharmacol Biochem Behav. 2014 Mar;118:10-5. 3. He J, Zhou H, Meng J, et al. Cardamonin retards progression of autosomal dominant polycystic kidney disease via inhibiting renal cyst growth and interstitial fibrosis[J]. Pharmacological Research. 2020: 104751. 4. Zhilei Wang, Guang Xu, Yuan Gao, Xiaoyan Zhan, Nan Qin, Shubin Fu, Ruisheng Li et al. Cardamonin from a medicinal herb protects against LPS-induced septic shock by suppressing NLRP3 inflammasome [J]. Acta Pharmaceutica Sinica B. 2019 Feb 14.

Citations

1. He J, Zhou H, Meng J, et al. Cardamonin retards progression of autosomal dominant polycystic kidney disease via inhibiting renal cyst growth and interstitial fibrosis. Pharmacological Research. 2020: 104751

Related compound libraries

This product is contained In the following compound libraries：

Inhibitor Library Flavonoid Natural Product Library Target-Focused Phenotypic Screening Library Covalent Natural Product Library Bioactive Compounds Library Max Anti-Aging Compound Library Apoptosis Compound Library Covalent Inhibitor Library Natural Product Library Bioactive Compound Library

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Keywords

(E)-Cardamonin 19309-14-9 Apoptosis Membrane transporter/Ion channel TRP/TRPV Channel Alpinetin chalcone Cardamomin Inhibitor Transient receptor potential channels (E)Cardamonin Cardamoni (E)-Cardamomin (E) Cardamonin (E)-Alpinetin chalcone Cardamonin (E)-Cardamoni TRP Channel inhibit inhibitor

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