Microbiology/Virology Parasite (+)-Emetine dihydrochloride hydrate

(+)-Emetine dihydrochloride hydrate

Catalog No. T0982   CAS 7083-71-8

Emetine is a drug used as both an anti-protozoal and to induce vomiting. It is produced from the ipecac root.

(+)-Emetine dihydrochloride hydrate, CAS 7083-71-8
Pack Size Availability Price/USD Quantity
5 mg In stock 30.00
10 mg In stock 50.00
25 mg In stock 78.00
50 mg In stock 100.00
100 mg Inquiry 140.00
200 mg Inquiry 196.00
1 mL * 10 mM (in DMSO) Inquiry 53.00
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Purity 100.00%
Purity 98.00%
Biological Description
Chemical Properties
Storage & Solubility Information
Description Emetine is a drug used as both an anti-protozoal and to induce vomiting. It is produced from the ipecac root.
Targets&IC50 Others
In vivo Emetine (0.002, 0.02, 0.2 and 2 mg/kg) does not induce any significant difference in body weight in mice with low-dose streptozotocin model of T1D. Administration of emetine not only attenuates blood glucose levels in dose-dependent way but also induces a persistent attenuation of blood glucose levels. Daily administration of emetine dose-dependently attenuates hyperglycemic response by d 21. Consistent with this observation, administration of emetine, but not the vehicle control, results in a sustained attenuation of blood glucose levels. Emetine improves disease severity in a spontaneous model of NOD T1D[3]. Emetine (1 mg/kg) reduces both leukemia burden in an in vivo xenotransplantation mouse model and the clonogenic capacity of leukemic cells upon treatment[4].
Cell Research
7.5×105 cells per mL are cultured in 96-well plates in complete medium. Emetine and Ara-C are added at indicated concentrations. Cell viability is measured by 7-AAD exclusion and Hoechst33342 positivity staining by flow cytometry; and cell count is obtained by volume in a FACSCantoII cytometer. Statistical analysis and EC50 determination are calculated in GraphPad. FlowJo software is used for flow cytometry analysis.
Molecular Weight 571.58
Formula C29H40N2O4·2HCl·H2O
CAS No. 7083-71-8


0-4℃ for short term (days to weeks), or -20℃ for long term (months).

Solubility Information

DMSO: 16.5 mg/mL

( < 1 mg/ml refers to the product slightly soluble or insoluble )


References and Literature
1. Matthews H, et al. Drug repositioning as a route to anti-malarial drug discovery: preliminary investigation of the in vitro anti-malarial efficacy of emetine dihydrochloride hydrate. Malar J. 2013 Oct 9;12:359. 2. Wu L, et al. PRRT2 truncated mutations lead to nonsense-mediated mRNA decay in Paroxysmal Kinesigenic Dyskinesia. Parkinsonism Relat Disord. 2014 Dec;20(12):1399-404. 3. Hudson LK, et al. Emetine Di-HCl attenuates Type 1 diabetes mellitus in mice. Mol Med. 2016 Jun 10;22. 4. Cornet-Masana JM, et al. Emetine induces chemosensitivity and reduces clonogenicity of acute myeloid leukemia cells. Oncotarget. 2016 Apr 26;7(17):23239-50.

Related compound libraries

This product is contained In the following compound libraries:
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