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Compound Libraries nsp16-Targeted compound library (CADD)

nsp16-Targeted compound library (CADD)

Catalog No. L1715
  Library Compound List   Excel SDF

Most viral mRNAs possess a 5'-terminal cap structure (m7GpppN) which is essential for efficient splicing, nuclear export, translation and stability. This structure undergoes methylation catalyzed by non-structural protein 16 (nsp16), 2'-O-ribose methyltransferase, at the ribose 2'-O position of the first and second nucleotide of the mRNA. Nsp16 provides the viral mRNA with the ability to camouflage and obscure itself from the host cell, thus preventing recognition and activation of the host immune response which is essential for successful viral infection. This protein can, therefore, act as another potential drug target for the SARS-CoV-2.

Based on the protein structure of nsp16 protein, we selected 281 top-ranked docked molecules into nsp16-Targeted compound library (CADD) by molecular docking virtual screening against 15,376 compound structures. To speed up the research and development of anti-SARS-CoV-2 drugs, we provide the virtual screening result for free!

Pack Size Price/USD
100 μL * 10 mM (in DMSO) 4710.00
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Product Description

  • A unique collection of 281 compounds having the potential of anti-SARS-CoV-2 activity, can be used for high throughput screening and high content screening;
  • Top-ranked docked compounds targeting nsp16 protein will improve the hit success rate;
  • Detailed compound information with structure, target, and biological activity description;
  • NMR and HPLC validated to ensure high purity and quality.

Library Customization

Targetmol Compound Libraries can be highly customized! Learn More

Packaging And Storage

  • Powder or pre-dissolved DMSO solutions in 96/384 well plate with optional 2D barcode
  • Shipped with blue ice
Request Library Compound List (L1715)

Library Composition

Adrenergic Receptor (12)
Nuclear factor erythroid 2-related factor 2 (9)
HEK293 (8)
Histone Methyltransferase (7)
Endogenous Metabolite (7)
Glucagon-like peptide 1 receptor (7)
Antioxidant (7)
Potassium Channel (7)
VEGFR (7)
Thyroid hormone receptor beta-1 (6)
Prostaglandin Receptor (6)
Beta-lactamase AmpC (6)
Cellular tumor antigen p53 (6)
DNA/RNA Synthesis (6)
Epigenetic Reader Domain (6)
FLT (5)
HIV Protease (5)
PKC (5)
RAAS (4)
Autophagy (4)
Calcium Channel (4)
Antibacterial (4)
Antibiotic (3)
CDK (3)
COX (3)
c-RET (3)
Integrin (3)
Geminin (3)
TNF (3)
TAM Receptor (3)
Thrombin (3)
Plasmodium falciparum (3)
PPAR (3)
Prelamin-A/C (3)
NF-κB (3)
Microtubule-associated protein tau (3)
NADPH (2)
Mothers against decapentaplegic homolog 3 (2)
PI3K (2)
PKA (2)
PAI-1 (2)
PDGFR (2)
P-gp (2)
Gap Junction Protein (2)
TAR DNA-binding protein 43 (2)
ROS (2)
Sirtuin (2)
Sodium Channel (2)
Transferase (2)
Dopamine Receptor (2)
EGFR (2)
Estrogen/progestogen Receptor (2)
Histamine Receptor (2)
LDL (2)
GPR (2)
c-Kit (2)
Akt (2)
5-HT Receptor (2)
AChR (2)
Aromatase (2)
Ataxin (2)
Ataxin-2 (2)
Aurora Kinase (1)
Breast cancer type 1 susceptibility protein (1)
BVDV (1)
Apoptosis (1)
Arginase (1)
Adenosine Receptor (1)
Acetyl-CoA Carboxylase (1)
Antifolate (1)
c-Met/HGFR (1)
DNA-PK (1)
DNA dC->dU-editing enzyme APOBEC-3F (1)
DNA polymerase eta (1)
Chk (1)
Cannabinoid Receptor (1)
Carbonic Anhydrase (1)
CaSR (1)
HDAC (1)
HER (1)
HIF (1)
HSV (1)
Human immunodeficiency virus 1 (1)
Huntingtin (1)
Hydroxylase (1)
Influenza Virus (1)
LHRH (1)
Lipase (1)
Luciferin 4-monooxygenase (1)
Lysosomal alpha-glucosidase (1)
lysosomal autophagy (1)
MEK (1)
Histone Acetyltransferase (1)
JAK (1)
JNK (1)
FAAH (1)
Ferroptosis (1)
FK506 binding protein 12 (1)
ERK (1)
GHSR (1)
Gamma-secretase (1)
Glucokinase (1)
Glutathione reductase (1)
GNRH Receptor (1)
Vaccinia virus (1)
Vitamin (1)
S1P Receptor (1)
S6 Kinase (1)
Raf (1)
RAR/RXR (1)
ribosome (1)
TGF-beta/Smad (1)
Topoisomerase (1)
Thyroid stimulating hormone receptor (1)
TLR (1)
Phospholipase (1)
PDK (1)
PD-1/PD-L1 (1)
Nuclear receptor ROR-gamma (1)
Opioid Receptor (1)
Proteasome (1)
MRP (1)
MT Receptor (1)
mTOR (1)
NADPH-oxidase (1)
MMP (1)
Niemann-Pick C1 protein (1)
NOD-like Receptor (NLR) (1)
Nonstructural protein 1 (1)
P2 Receptor (1)
P2X Receptor (1)
p38 MAPK (1)
P450 (1)
p53 (1)