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Compound Libraries nsp15-Targeted compound library (CADD)

nsp15-Targeted compound library (CADD)

Catalog No. L1719
  Library Compound List   Excel SDF

The 3-D structure of a potential drug target in a newly mapped protein of COVID-19, or coronavirus, has been solved by a team of researchers from the University of California, Riverside, the University of Chicago, the U.S. Department of Energy’s Argonne National Laboratory, and Northwestern University. (“Crystal structure of Nsp15 endoribonuclease NendoU from SARS-CoV-2”, BioRxiv)

In this study, the high-resolution crystal structure of endoribonuclease Nsp15/NendoU from SARS-CoV-2 was reported. The protein Nsp15 from SARS-CoV-2, is 89 percent identical to the protein from the earlier outbreak of SARS-CoV. Studies published in 2010 on SARS-CoV revealed inhibition of Nsp15 can slow viral replication. This suggests drugs designed to target Nsp15 could be developed as effective drugs against COVID-19.

Based on the protein structure of nsp15 protein, we selected 470 top-ranked docked molecules into nsp15-Targeted compound library (CADD) by molecular docking virtual screening against 15,376 compound structures. To speed up the research and development of anti-SARS-CoV-2 drugs, we provide the virtual screening result for free！

Pack Size Price/USD
100 μL * 10 mM (in DMSO) 7050.00
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Product Description

  • A unique collection of 470 compounds having the potential of anti-SARS-CoV-2 activity, can be used for high throughput screening and high content screening;
  • Top-ranked docked compounds targeting nsp15 protein will improve the hit success rate；
  • Detailed compound information with structure, target, and biological activity description；
  • NMR and HPLC validated to ensure high purity and quality.

Library Customization

Targetmol Compound Libraries can be highly customized! Learn More

Packaging And Storage

  • Powder or pre-dissolved DMSO solutions in 96/384 well plate with optional 2D barcode
  • Shipped with blue ice

Supporting Files

Library Handling Instructions (927 KB) Targetmol Library Catalog (13.2 MB) Request for Library Compostion in Excel and SDF files
Request Library Compound List (L1719)

Library Composition

Beta-lactamase AmpC (19)
Adrenergic Receptor (18)
Cellular tumor antigen p53 (18)
Prelamin-A/C (17)
Glucagon-like peptide 1 receptor (16)
Nuclear factor erythroid 2-related factor 2 (15)
Plasmodium falciparum (14)
Microtubule-associated protein tau (13)
HEK293 (13)
Mothers against decapentaplegic homolog 3 (10)
Endogenous Metabolite (10)
Histone Methyltransferase (9)
Geminin (9)
Thyroid hormone receptor beta-1 (9)
Prostaglandin Receptor (8)
DNA/RNA Synthesis (8)
5-HT Receptor (7)
Nuclear receptor ROR-gamma (7)
Nonstructural protein 1 (7)
VEGFR (6)
Dopamine Receptor (6)
c-Kit (6)
FK506 binding protein 12 (5)
Guanine nucleotide-binding protein G(s), subunit alpha (5)
P450 (5)
PDGFR (4)
RAAS (4)
Integrin (4)
Histamine Receptor (4)
Glucocorticoid Receptor (4)
Glycoprotein hormones alpha chain (4)
COX (4)
AChR (4)
Adenosine Receptor (4)
Ataxin (4)
Ataxin-2 (4)
Antibacterial (4)
Calcium Channel (3)
Aldehyde dehydrogenase 1A1 (3)
AMPK (3)
Antioxidant (3)
Antiviral (3)
Autophagy (3)
DNA polymerase iota (3)
Histone Acetyltransferase (3)
MMP (3)
NADPH (3)
TAR DNA-binding protein 43 (3)
Src (3)
Potassium Channel (3)
P2 Receptor (3)
PKC (2)
P-gp (2)
STAT (2)
Survival motor neuron protein (2)
TAM Receptor (2)
ribosome (2)
NMDAR (2)
MRP (2)
lysosomal autophagy (2)
Inositol monophosphatase 1 (2)
LDL (2)
HIV Protease (2)
HCV Protease (2)
HDAC (2)
EGFR (2)
c-Met/HGFR (2)
Bcr-Abl (2)
GPR (2)
GR (2)
ERK (2)
FGFR (2)
Antifection (2)
ATP-dependent Clp protease proteolytic subunit (2)
Vitamin (2)
TLR (2)
TNF (1)
Topoisomerase (1)
Transferase (1)
VDA (1)
Wnt/beta-catenin (1)
Thyroid stimulating hormone receptor (1)
Antibiotic (1)
ATM/ATR (1)
ATP Citrate Lyase (1)
ATPase (1)
ATPase family AAA domain-containing protein 5 (1)
Cannabinoid CB1 receptor (1)
Carbonic Anhydrase (1)
CDK (1)
Bradykinin Receptor (1)
Bromodomain adjacent to zinc finger domain protein 2B (1)
BTK (1)
Apoptosis (1)
Apoptosis inducer (1)
Aromatase (1)
Androgen Receptor (1)
Annexin A (1)
AhR (1)
Akt (1)
ALK (1)
Alpha-galactosidase A (1)
Alpha-synuclein (1)
Amino Acids and Derivatives (1)
Aberrant vpr protein (1)
Epigenetic Reader Domain (1)
FLT (1)
Fructose-bisphosphate aldolase (1)
Gamma-secretase (1)
Gap Junction Protein (1)
GTPase (1)
Glucokinase (1)
Hck (1)
Beta-2 adrenergic receptor (1)
c-Fms (1)
Chloride channel (1)
c-RET (1)
CSF-1R (1)
Cysteine Protease (1)
DHFR (1)
DNA Alkylation (1)
DPP-4 (1)
E1/E2/E3 Enzyme (1)
HIF (1)
HIF/HIF Prolyl-Hydroxylase (1)
HMG-CoA Reductase (1)
HSP (1)
Huntingtin (1)
IL Receptor (1)
Lethal(3)malignant brain tumor-like protein 1 (1)
LTR (1)
Luciferin 4-monooxygenase (1)
MAPK (1)
microRNA 21 (1)
IκB/IKK (1)
JNK (1)
NOD-like Receptor (NLR) (1)
Neuropeptide S receptor (1)
Niemann-Pick C1 protein (1)
Nucleoside Antimetabolite/Analog (1)
Opioid Receptor (1)
ROR (1)
Serotonin 6 (5-HT6) receptor (1)
Sigma receptor (1)
Sirtuin (1)
Sodium Channel (1)
Raf (1)
RAR/RXR (1)
Ras-related protein Rab-9A (1)
Relaxin receptor 1 (1)
Telomerase (1)
TGF-beta receptor type II (1)
Proteasome (1)
Phosphatase (1)
Phospholipase (1)
PI3K (1)
p53 (1)
PAI-1 (1)
PARP (1)
PKM (1)
PPAR (1)
Platelet aggregation (1)
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