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CNS-Penetrant Compound Library

Catalog No. L5900

Theblood–brain barrier(BBB) is a highly selectivesemipermeableborder that separates the circulatingbloodfrom the brain andextracellular fluidin thecentral nervous system(CNS). In its neuroprotective role, the blood–brain barrier functions to hinder the delivery of many potentially important diagnostic and therapeutic agents to the brain. Overcoming the difficulty of delivering therapeutic agents to specific regions of the brain presents a major challenge to treatment of most brain disorders. Choosing the compounds that could penetrate BBB into the compound library targeting CNS is critical for CNS drug discovery. Based on the scientific literature, TargetMol collects 90 out of 5000 compounds as CNS-Penetrant Compound Library, which can be used for CNS-Penetrant related research and drug screening for CNS diseases.

Pack Size	Price
100 μL * 10 mM (in DMSO)	USD 1800.00
250 μL * 10 mM (in DMSO)	USD 2700.00
1 mg	USD 2700.00

Product Description

A unique collection of 90 CNS-Penetrant compounds for high throughput screening (HTS) and high content screening (HCS);
Targets include Kinases, GPCR, and ion channels, etc.;
Effective tool for drug screening in brain disorders, such as brain tumor, mental disorders, and neurodegenerative diseases, etc.;
Safety and effectiveness of the small molecules have been demonstrated through preclinical and clinical research, and some of them are FDA approved;
Detailed compound information with structure, target, activity, IC50 value, and biological activity description;
Structurally diverse, medicinally active, and cell permeable and CNS penetrant;
NMR and HPLC/LCMS validated to ensure high purity and quality;

The compound library can be highly customized. You can select compounds, quantities, format (dry/solid or DMSO), plate map, and concentration to meet your specific requirement. Please check our Compound Library Instructions for more information.

Packaging and Storage

Powder or pre-dissolved DMSO solutions in 96 well plate with optional 2D barcode
Shipped with blue ice; Stable for One year as powder, 6 months at - 20 ° C in DMSO or 12months at -80 ° C in DMSO

Library Composition

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