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Home > Screening Libraries > TGF-beta Smad Compound Library

TGF-beta Smad Compound Library

Catalog No. L4100

Members of the transforming growth factor-β (TGF-β) family control growth, differentiation and apoptosis of cells, and have important functions during embryonic development. There are three known isoforms of TGF-β (TGF-β1, TGF-β2 and TGF-β3) expressed in mammalian tissues. TGF-β isoforms signal through three surface receptors, known as the TGF-β type I, type II, and type III receptors (TβRI, TβRII, and TβRIII, respectively) which are expressed on the surface of many cell types such as fibroblasts, lymphocytes, and hemopoietic cells, etc. The binding of TGF-β and receptors transduces the signals by phosphorylating carboxy-terminal serine residues of receptor-regulated (R-) Smads. The activated R-Smads form hetero-oligomeric complexes with a common-partner (co-) Smad, that is, Smad4 in vertebrate cells. The complexes translocate into the nucleus where they regulate the expression of target genes.

TGF-beta/Smad Compound Library from TargetMol, a unique collection of 44 TGF-beta/Smad signaling targeted compounds, can be used for research in TGF-beta/Smad signaling and related drug screening (high throughput and high content screening).

Pack Size Price
100 μL * 10 mM (in DMSO) USD 990.00
250 μL * 10 mM (in DMSO) USD 1665.00
1 mg USD 1665.00

Product Description

  • A unique collection of 44 TGF-beta/Smad signaling targeted compounds for high throughput and high content screening;
  • Bioactivity and safety confirmed by pre-clinical research and clinical trials;
  • Detailed compound information with structure, target, activity, IC50 value, and biological activity description;
  • Structurally diverse, medicinally active, and cell permeable;
  • NMR and HPLC validated to ensure high purity and quality;

The compound library can be highly customized. You can select compounds, quantities, format (dry/solid or DMSO), plate map, and concentration to meet your specific requirement. Please check our Compound Library Instructions for more information.

Packaging and Storage

  • Powder or pre-dissolved DMSO solutions in 96 well plate with optional 2D barcode
  • Shipped with dry ice.

Library Composition

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