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JAK STAT Compound Library

Catalog No. L3700

Cell signal transductionis the transmission of molecular signals via various proteins in asignaling cascade, which carries and amplifies the signal. TheJAK-STAT signaling pathwaycommunicates information from chemical signals outside of a cell to thecell nucleus, resulting in the activation of genes through a process calledtranscription. There are three key parts of JAK-STAT signaling:Janus kinases(JAKs),Signal Transducer and Activator of Transcription proteins(STATs), and receptors (which bind the chemical signals). JAK-STAT signaling pathway is a chain of interactions between proteins in a cell, and is involved in processes such asimmunity,cell division,cell deathandtumor formation. Disrupted JAK-STAT signaling may lead to a variety of diseases, such as skin conditions,cancers, and disorders affecting the immune system. There are 4 JAK proteins:JAK1,JAK2,JAK3andTYK2, and there are 7 STAT proteins:STAT1,STAT2,STAT3,STAT4,STAT5A,STAT5BandSTAT6.

JAK/STAT Compound Library from TargetMol, a unique collection of 145 compounds targeting JAK/STAT signaling, can be used for research in JAK/STAT signaling and related drug screening (high throughput and high content screening).

Pack Size Price
100 μL * 10 mM (in DMSO) USD 2320.00
250 μL * 10 mM (in DMSO) USD 4205.00
1 mg USD 4205.00

Product Description

  • A unique collection of 145 JAK/STAT signaling targeted compounds for high throughput and high content screening;
  • Effective tool for studying the JAK/STAT targets;
  • Bioactivity and safety confirmed by pre-clinical research and clinical trials;
  • Detailed compound information with structure, target, activity, IC50 value, and biological activity description;
  • Structurally diverse, medicinally active, and cell permeable;
  • NMR and HPLC validated to ensure high purity and quality;

The compound library can be highly customized. You can select compounds, quantities, format (dry/solid or DMSO), plate map, and concentration to meet your specific requirement. Please check our Compound Library Instructions for more information.

Packaging and Storage

  • Powder or pre-dissolved DMSO solutions in 96 well plate with optional 2D barcode
  • Shipped with blue ice; Stable for One year as powder, 6 months at - 20 ° C in DMSO or 12months at -80 ° C in DMSO

Library Composition

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