Cell signal transductionis the transmission of molecular signals via various proteins in asignaling cascade, which carries and amplifies the signal. TheJAK-STAT signaling pathwaycommunicates information from chemical signals outside of a cell to thecell nucleus, resulting in the activation of genes through a process calledtranscription. There are three key parts of JAK-STAT signaling:Janus kinases(JAKs),Signal Transducer and Activator of Transcription proteins(STATs), and receptors (which bind the chemical signals). JAK-STAT signaling pathway is a chain of interactions between proteins in a cell, and is involved in processes such asimmunity,cell division,cell deathandtumor formation. Disrupted JAK-STAT signaling may lead to a variety of diseases, such as skin conditions,cancers, and disorders affecting the immune system. There are 4 JAK proteins:JAK1,JAK2,JAK3andTYK2, and there are 7 STAT proteins:STAT1,STAT2,STAT3,STAT4,STAT5A,STAT5BandSTAT6.
JAK/STAT Compound Library from TargetMol, a unique collection of 145 compounds targeting JAK/STAT signaling, can be used for research in JAK/STAT signaling and related drug screening (high throughput and high content screening).
|100 μL * 10 mM (in DMSO)||USD 2320.00|
|250 μL * 10 mM (in DMSO)||USD 4205.00|
|1 mg||USD 4205.00|
The compound library can be highly customized. You can select compounds, quantities, format (dry/solid or DMSO), plate map, and concentration to meet your specific requirement. Please check our Compound Library Instructions for more information.