Compound Libraries Anti-cancer Metabolism Compound Library

Anti-cancer Metabolism Compound Library

Catalog No. L2130
  Library Compound List   Excel SDF

Cancer metabolism has emerged as an important area of research in recent years. Reprogramming of the cellular energy metabolism, essential for cancer cell proliferation and tumor development, constitutes an emerging hallmark of cancer and may serve as a biochemical basis for new therapeutic intervention. From the abnormal aerobic glycolysis effect in tumor cells was first discovered by German scientist Warburg in the early 1920s to now on all aspects of tumor metabolic activity (sugar, fat, amino acids, etc.) analysis and complex metabolic regulation network discovery, the study of tumor metabolism has entered into a more striking height. Distinct metabolic pathways (glycolysis and glutaminolysis), key regulators of aerobic glycolysis (AMPK, mTOR, HIF-1, c-Myc, p53, etc.), and key metabolism enzymes (PKM, HK, PFK, PK, IDH, GLS) might be the key targets for tumor therapeutics. Developing inhibitors targeting dysregulated metabolic enzymes and pathways may represent a promising strategy to overcome drug resistance in cancer therapy.

A unique collection of 237 cancer cellular metabolism related compounds by TargetMol can be used for cancer related research and high throughput and high content screening for anti-cancer drugs.

Pack Size Price/USD
100 μL * 10 mM (in DMSO) 2880.00
250 μL * 10 mM (in DMSO) 5060.00
1 mg 5060.00
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Product Description

  • A unique collection of 237 cancer cellular metabolism related compounds for cancer research and high throughput screening (HTS) and high content screening (HCS);
  • Bioactivity and safety confirmed by pre-clinical research and clinical trials;
  • Covers 16 major targets related to cancer cellular metabolism (glucose, proteins, lipids and nucleic acids) including ACL, CA, FASN, GLUT, GLS, HMG-CoA, MAGL, MCTs, PDH, PDK, PKM, etc.; Effect tool for research in cancer metabolism and anti-cancer drug screening.
  • Detailed compound information with structure, target, activity, IC50 value, and biological activity description;
  • Structurally diverse, medicinally active, and cell permeable;
  • NMR and HPLC validated to ensure high purity and quality;

Library Customization

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Packaging And Storage

  • Powder or pre-dissolved DMSO solutions in 96 well plate with optional 2D barcode
  • Shipped with blue ice
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Library Composition

Carbonic Anhydrase (20)
DNA/RNA Synthesis (20)
Dehydrogenase (11)
PDK (9)
HMG-CoA Reductase (9)
DHFR (6)
transporter (6)
Fatty Acid Synthase (5)
Monocarboxylate transporter (4)
MTH1 (3)
Lipase (3)
PKM (3)
Autophagy (3)
Chk (3)
AMPK (3)
AChR (2)
Akt (2)
ATPase (2)
CDK (2)
GluR (2)
Glutathione reductase (2)
Potassium Channel (2)
Thrombin (2)
Nrf2 (2)
Lipid (2)
PKA (2)
NPC1L1 (1)
P450 (1)
p53 (1)
PKC (1)
Phospholipase (1)
PI3K (1)
mTOR (1)
Topoisomerase (1)
Transferase (1)
Reverse Transcriptase (1)
Sodium Channel (1)
Syk (1)
Tyrosinase (1)
UGT (1)
Vitamin (1)
Wnt/beta-catenin (1)
Hedgehog/Smoothened (1)
HER (1)
HIF (1)
Histone Demethylase (1)
HSV (1)
Hydroxylase (1)
IκB/IKK (1)
GABA Receptor (1)
Glucocorticoid Receptor (1)
Glucokinase (1)
DNA-PK (1)
EGFR (1)
Epigenetic Reader Domain (1)
FAAH (1)
CFTR (1)
c-Kit (1)
COX (1)
Calcium Channel (1)
Casein Kinase (1)
CAT (1)
ABC (1)
Arginase (1)
ATP Citrate Lyase (1)