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TargetMol | Compound Library

Anti-Alzheimer's Disease Compound Library

Catalog No. L9840

Alzheimer's disease (AD) is a progressive neurodegenerative disease with deficits in recent memory, wordfinding, and language difficulties, and gradually progresses to global cognitive impairment. The cognitive deficits are accompanied by a variety of abnormal neurological and psychiatric symptoms that increase in frequency and severity as the disease progresses. The cause of Alzheimer's disease is unknown but the fifth-leading cause of death among those age 65 and older. The pathological features of AD mainly include cholinergic dysfunction, extracellular accumulation and deposition of Aβ peptides, intracellular neurofibrillary tangles, and other aberrant signaling pathways. Scientists have found that reducing brain Aβ levels, preventing the excessive phosphorylation of tau protein, rendering mitochondria resistant to damage, protecting neurons from apoptotic processes, controlling microglial activation, inhibiting the release of interleukin-2 and TNF-α, preventing oxidative stress damage; regulating the targets in cholinergic system, inhibiting the over activation of NMDA receptor to reduce the excitotoxicity can halt Alzheimer's disease.  Although Alzheimer's disease (AD) is the world's leading cause of dementia and the population of patients with AD continues to grow, no new therapies have been approved in more than a decade. Over the past decade, the focus of drug discovery and development efforts has shifted from symptom improving toward disease-modifying therapies for AD; that is, treatments whose aim is to affect the underlying disease process by impacting one or more of the many brain changes characteristic of AD. Many clinical trials of single-agent therapies have failed to affect disease progression or symptoms compared with placebo. The complex pathophysiology of AD may necessitate combination treatments rather than monotherapy. In addition, small molecules targeting neural stem cells (NSCs) regeneration represents a new drug discovery strategy. TargetMol's Anti-Alzheimer's Disease Compound Library, a collection of 1881 compounds with anti-AD activities or acting on main drug targets of AD, can be used for related drug discovery and pharmacology research.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.

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Catalog No. L9840

Anti-Alzheimer's Disease Compound Library

sizeIn stock

  • 1 mg
  • 30 μL x 10 mM (in DMSO)
  • 50 μL x 10 mM (in DMSO)
  • 100 μL x 10 mM (in DMSO)
  • 250 μL x 10 mM (in DMSO)
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Packaging And Storage Packaging And Storage

  • Powder or pre-dissolved DMSO solutions in 96/384 well plate with optional 2D barcode
  • Shipped with blue ice
  • This compound library is provided at a concentration of 10 mM in DMSO. A small number of compounds may be provided in different solvents or concentrations due to solubility or stability requirements. Please refer to the specific product information for details.

Product Description Product Description

  • A unique collection of 1881 compounds with anti-AD activities or acting on main drug targets of AD can be used for HTS and HCS.
  • Targets include tau protein, γ Secretase, 5-HT Receptor, BACE, etc.
  • Some of them are FDA approved.?
  • Structurally diverse, medicinally active, and cell permeable;
  • Detailed information about compound structure, target, activity, IC50, etc.
  • NMR and HPLC/LCMS validated to ensure high purity and quality.

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Library Customization | TargetMol Library Composition

5-HT Receptor
AChR
Dopamine Receptor
Apoptosis
PPAR
Cholinesterase (ChE)
Wnt/beta-catenin
TNF
Autophagy
Adrenergic Receptor
Beta Amyloid
GSK-3
Histamine Receptor
AMPK
Endogenous Metabolite
TLR
Antibacterial
NF-κB
Gamma-secretase
GABA Receptor
Serotonin Transporter
IL Receptor
Parasite
COX
Potassium Channel
Calcium Channel
Norepinephrine
CDK
Interleukin
NOD-like Receptor (NLR)
MAO
Reactive Oxygen Species
Cytochromes P450
NOD
Akt
Sodium Channel
Monoamine Oxidase
BACE
NO Synthase
p38 MAPK
Antioxidant
ERK
Beta-Secretase
Antibiotic
HIV Protease
PARP
iGluR
Influenza Virus
Microtubule Associated
Sigma receptor
Ferroptosis
Virus Protease
PDE
Drug Metabolite
Prostaglandin Receptor
TRP/TRPV Channel
GluR
SARS-CoV
Bcl-2 Family
Src
Antifungal
PKC
STAT
PI3K
JNK
Mitophagy
Caspase
MMP
MAPK
Tyrosinase
Transferase
EGFR
P-gp
NOS
Dehydrogenase
VEGFR
Molecular Glues
JAK
transporter
Nrf2
GPCR
HCV Protease
PKA
Mitochondrial Metabolism
Glucosidase
CaMK
Casein Kinase
Cannabinoid Receptor
HIF/HIF Prolyl-Hydroxylase
DYRK
NMDAR
ABC Transporter
ROS
Fatty Acid Synthase
PDGFR
Epigenetic Reader Domain
Lipoxygenase
mTOR
DNA/RNA Synthesis
Antiviral
IκB/IKK
HDAC
Phospholipase
FGFR
FLT
Anti-infection
S6 Kinase
RAAS
Phosphatase
Melatonin Receptor
Bcr-Abl
P2X Receptor
Monoamine Transporter
Opioid Receptor
HSV
Aurora Kinase
IGF-1R
TGF-beta/Smad
Porcupine
Sirtuin
Ligand for E3 Ligase
Hydroxylase
Proteasome
Adenylyl Cyclase
MyD88
IFNAR
HBV
Estrogen Receptor/ERR
Leukotriene Receptor
Immunology/Inflammation related
PAFR
Antifection
Stearoyl-CoA Desaturase (SCD)
Trk receptor
AIM2
Pyroptosis
IKZF
Thyroid hormone receptor(THR)
Advanced Glycation End Products
Chloride channel
Carbonic Anhydrase
Histone Methyltransferase
Integrin
Amino Acids and Derivatives
Estrogen/progestogen Receptor
Adenosine Receptor
Histone Demethylase
c-Myc
MRP
Serine Protease
Cysteine Protease
Glucocorticoid Receptor
Topoisomerase
E1/E2/E3 Enzyme
LDL
MT Receptor
GlyT
CCR
Angiotensin-converting Enzyme (ACE)
Chk
cAMP
ATP Citrate Lyase
Lipid
PGE Synthase
Survivin
Acyltransferase
ATM/ATR
Retinoid Receptor
c-Fms
MEK
c-Kit
p53
FOXO3
Melanin-concentrating Hormone Receptor (MCHR)
Proton pump
PROTACs
CAT
Transaminase
Monocarboxylate transporter
NPC1L1
DHFR
Piezo Channel
Dynamin
YAP
Arginase
Glutaminyl Cyclase
LTR
Arrestin
PERK
Tie-2
gp120/CD4
GTPase
OCT
Cholecystokinin Receptor
Tyrosine Kinases
Hck
Serine/threonin kinase
Liver X Receptor
FXR
Neurotensin Receptor
Glucokinase
Amylase
Aryl Hydrocarbon Receptor
IDO
CSF-1R
SIK
Annexin A
FLAP
Raf
GRK
Guanylate cyclase
Bombesin Receptor
Hedgehog/Smoothened
ACK1
PTEN
Somatostatin
Epoxide Hydrolase
DNA
Androgen Receptor
Indoleamine 2,3-Dioxygenase (IDO)
Telomerase
SGLT
Huntingtin
Aminopeptidase
Histone Acetyltransferase
GluCls
PAI-1
RSV
Methionine Adenosyltransferase (MAT)
Hippo pathway
GST
Reverse Transcriptase
Aromatase
PDK
FOXO
PLK
HIF
c-RET
MDM-2/p53
DAPK
DNA Methyltransferase
NADPH-oxidase
Thrombin
FAK
Liposome
CFTR
PKM
ADC Cytotoxin
BTK

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