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Compound Libraries Tyrosine kinase inhibitor library

Tyrosine kinase inhibitor library

Catalog No. L2200
  Library Compound List   Excel SDF

A protein kinase is a kinase enzyme that modifies other molecules, mostly proteins, by chemically adding phosphate groups to them (phosphorylation) to regulate the majority of cellular pathways, especially those involved in signal transduction. Phosphorylation usually results in a functional change of the target protein (substrate) by changing enzyme activity, cellular location, or association with other proteins. Of the 518 known kinases, the most successful class for drug targeting is the tyrosine kinase family consisting of 90 distinct and diverse members. Abnormal expression of PTK usually leads to cell proliferation disorders, and is closely related to tumor invasion, metastasis and tumor angiogenesis. More recently, PTKs play a pivotal role in inflammatory diseases such as idiopathic pulmonary fibrosis.

The Tyrosine Kinase Inhibitors Library by TargetMol, containing 640 tyrosine kinase inhibitors, can be used for research in tyrosine kinase signaling, and drug screening for related diseases.

Pack Size Price/USD
100 μL * 10 mM (in DMSO) 10661.00
250 μL * 10 mM (in DMSO) 17576.00
1 mg 17576.00
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Product Description

  • A unique collection of 640 tyrosine kinase inhibitors for high throughput screening and high content screening for drug discovery in tyrosine kinase related diseases;
  • Bioactivity and safety confirmed by pre-clinical research and clinical trials, and some of them are approved by FDA;
  • Targets include c-Kit, c-Met, EGFR, FGFR, SRC, JAK, SYK, Btk, Bcr-Abl, etc;
  • Detailed compound information with structure, target, activity, IC50 value, and biological activity description;
  • Structurally diverse, medicinally active, and cell permeable;
  • NMR and HPLC validated to ensure high purity and quality;

Library Customization

Targetmol Compound Libraries can be highly customized! Learn More

Packaging And Storage

  • Powder or pre-dissolved DMSO solutions in 96/384 well plate with optional 2D barcode
  • Shipped with blue ice
Request Library Compound List (L2200)

Library Composition

EGFR (100)
VEGFR (91)
Src (58)
FGFR (54)
PDGFR (53)
FLT (48)
JAK (46)
c-Kit (41)
c-Met/HGFR (41)
ALK (38)
Bcr-Abl (38)
Tyrosine Kinases (35)
Raf (26)
BTK (25)
c-RET (22)
HER (22)
TAM Receptor (21)
Trk receptor (21)
MEK (19)
CDK (15)
IGF-1R (14)
Aurora Kinase (13)
PI3K (13)
Syk (12)
FAK (12)
mTOR (11)
PKA (10)
c-Fms (10)
CSF-1R (10)
PKC (9)
TGF-beta/Smad (8)
S6 Kinase (7)
DNA-PK (7)
Discoidin Domain Receptor (DDR) (6)
Tie-2 (6)
Potassium Channel (6)
ROCK (5)
Serine/threonin kinase (5)
p38 MAPK (5)
Akt (5)
ATM/ATR (5)
AChR (5)
Ephrin Receptor (5)
ERK (5)
Chk (4)
MLK (4)
ROS (4)
MAPK (4)
PYK2 (4)
Tyrosinase (4)
TNF (3)
Casein Kinase (3)
DNA/RNA Synthesis (3)
ACK (3)
Apoptosis (3)
5-HT Receptor (3)
Hck (3)
DYRK (3)
IκB/IKK (3)
JNK (3)
Microtubule Associated (2)
Histone Methyltransferase (2)
HSP (2)
GSK-3 (2)
Estrogen/progestogen Receptor (2)
Glucokinase (2)
CaMK (2)
Adrenergic Receptor (2)
Dehydrogenase (2)
SGK (2)
Serine Protease (2)
PPAR (2)
PTEN (2)
PLK (2)
P450 (2)
PDE (1)
NADPH (1)
NAMPT (1)
NF-κB (1)
Pim (1)
Monoamine Transporter (1)
MTH1 (1)
PDK (1)
Phospholipase (1)
PTP1B (1)
Prostaglandin Receptor (1)
Sodium Channel (1)
STAT (1)
VDA (1)
DNA Alkylation (1)
Dopamine Receptor (1)
cell cycle arrest (1)
CRM1 (1)
AhR (1)
Adenosine Receptor (1)
Antibacterial (1)
Antioxidant (1)
Antiviral (1)
Autophagy (1)
GRK (1)
FAAH (1)
Haspin Kinase (1)
HDAC (1)
E1/E2/E3 Enzyme (1)
Epigenetic Reader Domain (1)
Free radical scavengers (1)
GABA Receptor (1)
Glucocorticoid Receptor (1)
HIF (1)
Histamine Receptor (1)
IL Receptor (1)
Integrin (1)
IRAK (1)
LDL (1)
LRRK2 (1)
lysosomal autophagy (1)
MAO (1)