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Tyrosine kinase inhibitor library

Catalog No. L2200

Library Compound List Excel SDF

A protein kinase is a kinase enzyme that modifies other molecules, mostly proteins, by chemically adding phosphate groups to them (phosphorylation) to regulate the majority of cellular pathways, especially those involved in signal transduction. Phosphorylation usually results in a functional change of the target protein (substrate) by changing enzyme activity, cellular location, or association with other proteins. Of the 518 known kinases, the most successful class for drug targeting is the tyrosine kinase family consisting of 90 distinct and diverse members. Abnormal expression of PTK usually leads to cell proliferation disorders, and is closely related to tumor invasion, metastasis and tumor angiogenesis. More recently, PTKs play a pivotal role in inflammatory diseases such as idiopathic pulmonary fibrosis.

The Tyrosine Kinase Inhibitors Library by TargetMol, containing 560 tyrosine kinase inhibitors, can be used for research in tyrosine kinase signaling, and drug screening for related diseases.

Pack Size	Price/USD
100 μL * 10 mM (in DMSO)	9330.00
250 μL * 10 mM (in DMSO)	15380.00
1 mg	15380.00

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Product Description

A unique collection of 560 tyrosine kinase inhibitors for high throughput screening and high content screening for drug discovery in tyrosine kinase related diseases;
Bioactivity and safety confirmed by pre-clinical research and clinical trials, and some of them are approved by FDA;
Targets include c-Kit, c-Met, EGFR, FGFR, SRC, JAK, SYK, Btk, Bcr-Abl, etc;
Detailed compound information with structure, target, activity, IC50 value, and biological activity description;
Structurally diverse, medicinally active, and cell permeable;
NMR and HPLC validated to ensure high purity and quality;

Library Customization

Targetmol Compound Libraries can be highly customized! Learn More

Packaging And Storage

Powder or pre-dissolved DMSO solutions in 96 well plate with optional 2D barcode
Shipped with blue ice

Supporting Files

Library Handling Instructions (927 KB) Targetmol Library Catalog (13.2 MB) Request for Library Compostion in Excel and SDF files

Library Composition

EGFR (78)

VEGFR (73)

PDGFR (42)

FLT (41)

Src (41)

FGFR (39)

c-Kit (37)

ALK (31)

c-Met/HGFR (27)

Bcr-Abl (26)

JAK (23)

Tyrosine Kinases (21)

TAM Receptor (15)

HER (15)

IGF-1R (15)

Raf (13)

c-RET (12)

CDK (12)

Trk receptor (12)

BTK (10)

Aurora Kinase (8)

FAK (8)

Syk (8)

Chk (6)

PKC (6)

PKA (5)

c-Fms (5)

CSF-1R (5)

GSK-3 (4)

IκB/IKK (4)

PYK2 (4)

mTOR (4)

JNK (3)

Potassium Channel (3)

PI3K (3)

Ephrin Receptor (3)

Adrenergic Receptor (3)

ROS (3)

S6 Kinase (3)

Serine/threonin kinase (3)

Tyrosinase (3)

Tie-2 (2)

Akt (2)

AChR (2)

ACK (2)

ERK (2)

Estrogen/progestogen Receptor (2)

DNA-PK (2)

Hck (2)

DYRK (2)

PDK (2)

P450 (2)

LDL (2)

NADPH (2)

Integrin (2)

MAPK (2)

MEK (1)

Microtubule Associated (1)

MLK (1)

Monoamine Transporter (1)

MTH1 (1)

lysosomal autophagy (1)

IL Receptor (1)

HIF (1)

HSP (1)

PDE (1)

p38 MAPK (1)

Phospholipase (1)

Pim (1)

ROCK (1)

PLK (1)

HDAC (1)

GABA Receptor (1)

Gap Junction Protein (1)

Glucocorticoid Receptor (1)

Dopamine Receptor (1)

Dehydrogenase (1)

DNA/RNA Synthesis (1)

FAAH (1)

Epigenetic Reader Domain (1)

Adenosine Receptor (1)

Casein Kinase (1)

Antiviral (1)

CRM1 (1)

TNF (1)

VDA (1)

Sodium Channel (1)

Serine Protease (1)

TGF-beta/Smad (1)

Products are chemical reagents for research use only and are not intended for human use. We do not sell to patients.