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Compound Libraries Target-Focused Phenotypic Screening Library

Target-Focused Phenotypic Screening Library

Catalog No. L9500
  Library Compound List   Excel SDF

TargetMol offers a high quality Target-focused Phenotypic Screening Library (1832 compounds in total) with maximal biological and chemical diversity for such empirical approaches. Phenotypic approaches use semi-empirical methods that do not require much knowledge of the target and understanding of the mechanism. A recent analysis revealed the phenotypic approaches to be the more successful strategy for small-molecule, first-in-class medicines. The rationalization for this success was the unbiased identification of the molecular mechanism of action (MMOA). In addition, an understanding of mechanism is not required for regulatory approval; the regulatory agencies are less concerned with the MMOA of a compound than with whether it is effective. It can be argued that in seeking the best path to new medicines, academic science should be focusing not on gene-based, hypothesis-driven research but on translating disease knowledge into disease-relevant phenotypic assays for screening and chemical biology approaches to screening and target identification as well as on systematic approaches to understanding the MMOA. Greater focus on translational research should lead to greater access to more reliable phenotypic assays.

Use of well-annotated bioactive compounds with clear targets for phenotypic screening can also narrow the scope of targets that are needed to be validated, therefore, it is an effective tool for target identification or validation.

Given the potential applications of a Phenotypic Screening Library, the focus of the compounds selection strategy lies on biodiversity and maximal coverage of chemical space, aimed at providing hits for a wide spectrum of biological goals. This library finally was developed to contain a set of compounds with confirmed biological activity for more than 600 drug targets and includes 2-4 structurally diverse compounds for each target.

Pack Size Price/USD
100 μL * 10 mM (in DMSO) 14280.00
250 μL * 10 mM (in DMSO) 23800.00
1 mg 23800.00
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Product Description

  • A unique collection of 1832 annotated bioactive compounds with clear targets, suitable for phenotypic screening;
  • Cover more than 600 drug targets, Structurally diverse;
  • 2-4 structurally diversified compounds for the same annotated 'on-target' to increase the success rate of target identification (enables the generation of much stronger target–phenotype hypotheses);
  • Detailed information about compound structure, target, activity, etc.;
  • NMR and HPLC/LCMS validated to ensure high purity and quality.

Library Customization

Targetmol Compound Libraries can be highly customized! Learn More

Packaging And Storage

  • Powder or pre-dissolved DMSO solutions in 96/384 well plate with optional 2D barcode
  • Shipped with blue ice
Request Library Compound List (L9500)

Library Composition

AChR (56)
5-HT Receptor (44)
Adrenergic Receptor (44)
VEGFR (36)
DNA/RNA Synthesis (35)
PI3K (29)
P450 (28)
Epigenetic Reader Domain (27)
FGFR (25)
PDE (25)
Histone Methyltransferase (24)
TRP/TRPV Channel (23)
Bcr-Abl (22)
GluR (21)
CDK (20)
Microtubule Associated (20)
PDGFR (19)
Raf (19)
HDAC (19)
EGFR (19)
Src (19)
GPR (18)
GABA Receptor (18)
RAAS (17)
HIV Protease (17)
PPAR (16)
c-Met/HGFR (16)
Topoisomerase (16)
c-Kit (15)
Dopamine Receptor (15)
COX (15)
Potassium Channel (15)
Opioid Receptor (15)
Histamine Receptor (15)
JAK (15)
MAO (15)
HCV Protease (14)
p38 MAPK (14)
DNA Alkylation (14)
FLT (14)
Estrogen/progestogen Receptor (14)
TNF (14)
Vitamin (14)
ERK (13)
BCL (13)
mTOR (13)
Histone Demethylase (12)
Gamma-secretase (12)
Glucokinase (12)
Cannabinoid Receptor (11)
Carbonic Anhydrase (11)
IL Receptor (11)
P2 Receptor (11)
PKC (11)
Retinoid Receptor (11)
STAT (11)
Wnt/beta-catenin (10)
S1P Receptor (10)
Sirtuin (10)
Sodium Channel (10)
NF-κB (10)
HSP (10)
HIF (10)
NMDAR (10)
Aurora Kinase (10)
Autophagy (10)
CXCR (10)
CaMK (9)
Beta Amyloid (9)
Chk (9)
Adenosine Receptor (9)
ATPase (9)
IκB/IKK (9)
Serine Protease (9)
ribosome (9)
TGF-beta/Smad (9)
Trk receptor (9)
Sigma receptor (8)
ROR (8)
NOS (8)
PARP (8)
JNK (8)
IDO (8)
MEK (8)
MMP (8)
ALK (8)
Akt (8)
Caspase (8)
Calcium Channel (8)
Dehydrogenase (8)
DNA-PK (8)
DUB (8)
GSK-3 (8)
Hedgehog/Smoothened (7)
BTK (7)
ATM/ATR (7)
Mdm2 (7)
NADPH (7)
HMG-CoA Reductase (7)
S6 Kinase (7)
Serine/threonin kinase (7)
Prostaglandin Receptor (7)
Reductase (7)
Thyroid hormone receptor(THR) (7)
Syk (7)
TLR (6)
SGLT (6)
Phospholipase (6)
Lipase (6)
CFTR (6)
Chloride channel (5)
CCR (5)
c-Fms (5)
Casein Kinase (5)
Aromatase (5)
AhR (5)
GR (5)
Glucocorticoid Receptor (5)
Endothelin Receptor (5)
Cysteine Protease (5)
Lipoxygenase (5)
Monocarboxylate transporter (5)
MRP (5)
NOD (5)
PKM (5)
OX Receptor (5)
ROCK (5)
Reverse Transcriptase (5)
Rho (5)
Proteasome (5)
Transferase (5)
Tyrosine Kinases (5)
Trace amine-associated receptor 1 (4)
Transcriptional regulator ERG (4)
Thyroid stimulating hormone receptor (4)
Tie-2 (4)
Thioredoxin glutathione reductase (4)
Thioredoxin reductase 1, cytoplasmic (4)
Thrombin (4)
Thyroid hormone receptor beta-1 (4)
TAM Receptor (4)
TAR DNA-binding protein 43 (4)
Streptokinase A (4)
Tyrosinase (4)
Ras-related protein Rab-9A (4)
Prelamin-A/C (4)
PKA (4)
ROS (4)
Short transient receptor potential channel 4 (4)
Serotonin 2c (5-HT2c) receptor (4)
Neuropeptide S receptor (4)
Nuclear factor erythroid 2-related factor 2 (4)
Nuclear receptor ROR-gamma (4)
Niemann-Pick C1 protein (4)
PD-1/PD-L1 (4)
p53 (4)
p97 (4)
PLK (4)
Phosphorylase (4)
Parasite (4)
P-glycoprotein 1 (4)
P-gp (4)
Phosphatase (4)
Nonstructural protein 1 (4)
Norepinephrine (4)
Mothers against decapentaplegic homolog 3 (4)
Monoamine oxidase B (4)
Metabotropic glutamate receptor 5 (4)
microRNA 21 (4)
LRRK2 (4)
Luciferin 4-monooxygenase (4)
Lysosomal alpha-glucosidase (4)
Lipid (4)
Kinesin (4)
Large T antigen (4)
Lethal(3)malignant brain tumor-like protein 1 (4)
Inositol monophosphatase 1 (4)
Histone Acetyltransferase (4)
IGF-1R (4)
Huntingtin (4)
Cruzipain (4)
CSF-1R (4)
DHFR (4)
DNA dC->dU-editing enzyme APOBEC-3F (4)
DNA Methyltransferase (4)
DNA polymerase eta (4)
DNA polymerase iota (4)
Endoplasmic reticulum-associated amyloid beta-peptide-binding protein (4)
DPP-4 (4)
GPCR19 (4)
Glutaminase kidney isoform, mitochondrial (4)
Glycoprotein hormones alpha chain (4)
Guanine nucleotide-binding protein G(s), subunit alpha (4)
HBV (4)
Geminin (4)
Glucagon-like peptide 1 receptor (4)
FXR (4)
FAAH (4)
Factor Xa (4)
FK506 binding protein 12 (4)
FAK (4)
Aldehyde dehydrogenase 1A1 (4)
4'-phosphopantetheinyl transferase ffp (4)
ABC (4)
ATPase family AAA domain-containing protein 5 (4)
ATP-dependent Clp protease proteolytic subunit (4)
ATP-dependent DNA helicase Q1 (4)
ATP-dependent molecular chaperone HSP82 (4)
Alpha-galactosidase A (4)
Alpha-synuclein (4)
AMPK (4)
Androgen Receptor (4)
Anthrax lethal factor (4)
CaSR (4)
Beta-glucocerebrosidase (4)
Beta-lactamase AmpC (4)
BMI-1 (4)
Breast cancer type 1 susceptibility protein (4)
Bromodomain adjacent to zinc finger domain protein 2B (3)
Beta-2 adrenergic receptor (3)
Cell wall (3)
CETP (3)
c-Myc (3)
Antifungal (3)
Arachidonate 15-lipoxygenase, type II (3)
Ataxin (3)
ACAT (3)
15-hydroxyprostaglandin dehydrogenase [NAD+] (3)
Fatty Acid Synthase (3)
FAD-linked sulfhydryl oxidase ALR (3)
G protein-coupled receptor 44 (3)
HER (3)
GNRH Receptor (3)
E1/E2/E3 Enzyme (3)
DNA gyrase (3)
Ephrin Receptor (3)
Epoxide hydratase (3)
C-X-C chemokine receptor type 7 (3)
c-RET (3)
Cytochrome P450 1A2 (3)
HIF/HIF Prolyl-Hydroxylase (3)
Isocitrate dehydrogenase [NADP] cytoplasmic (3)
LIM Kinase (3)
LDL (3)
Lipoxin A4 receptor (3)
LTR (3)
Microtubule-associated protein tau (3)
MNK (3)
Na-K-Cl cotransporter (3)
Neurokinin 3 receptor (3)
Neurokinin receptor (3)
PDK (3)
Porcupine (3)
Protease-activated Receptor (3)
Proton pump (3)
Survival motor neuron protein (3)
Telomerase (3)
transporter (3)
Tumor susceptibility gene 101 protein (3)
Tyrosyl-DNA phosphodiesterase 1 (3)
Voltage-gated T-type calcium channel alpha-1G subunit (3)
Voltage-gated T-type calcium channel alpha-1H subunit (2)
Wee1 (2)
UGT (2)
Vanilloid receptor (2)
Vasopressin Receptor (2)
Testis-specific androgen-binding protein (2)
TGF-beta receptor type II (2)
Survivin (2)
PTEN (2)
Prostaglandin E synthase (2)
Pim (2)
Runt-related transcription factor 1/Core-binding factor subunit beta (2)
PGE Synthase (2)
PERK (2)
Phosphodiesterase 5A (2)
PAFR (2)
PAI-1 (2)
Paired box protein Pax-8 (2)
MTH1 (2)
NAMPT (2)
Monoamine Transporter (2)
MLK (2)
Melatonin Receptor (2)
MAPK (2)
Liver X Receptor (2)
Integrin (2)
Interleukin Related (2)
Hydroxylase (2)
HSV (2)
Influenza Virus (2)
Cytochrome P450 2C9 (2)
Cytochrome P450 19A1 (2)
DNA dC->dU-editing enzyme APOBEC-3G (2)
Estrogen receptor alpha (2)
Endogenous Metabolite (2)
DprE1 (2)
Dopamine D2 receptor (2)
GlyT (2)
Formyl peptide receptor 1 (2)
GluCls (2)
Gap Junction Protein (2)
advanced glycation end products (2)
Aldo-keto-reductase family 1 member C3 (2)
Acetyl-CoA Carboxylase (2)
ACK (2)
Acyltransferase (2)
Adenosine A1 receptor (2)
Antifection (2)
C-C chemokine receptor type 5 (2)
Carboxypeptidase(CPG2) (2)
Butyrylcholinesterase (2)
cAMP (2)
BACE (2)
BCRP (1)
CAT (1)
Cholesteryl ester transfer protein (1)
Arginase (1)
Annexin A (1)
ATP Citrate Lyase (1)
Excitatory amino acid transporter 1 (1)
Ferroptosis (1)
Hck (1)
DNA Alkylator/Crosslinker (1)
Hippo pathway (1)
IP3 Receptor  (1)
Keap1-Nrf (1)
Menin/Histone-lysine N-methyltransferase MLL (1)
lysosomal autophagy (1)
MPO (1)
MT Receptor (1)
Peroxisome proliferator-activated receptor gamma (1)
Serotonin Transporter (1)
SGK (1)
Pyruvate kinase isozymes M1/M2 (1)
Wnk (1)