Compound Libraries Small Molecule Immuno-Oncology Compound Library

Small Molecule Immuno-Oncology Compound Library

Catalog No. L2170
  Library Compound List   Excel SDF

Traditional cancer therapies include surgery, radiation therapy, and chemotherapy. With the rapid development of science and technology in medicine, new cancer therapies such as immunotherapy, targeted therapy, radiofrequency ablation for cancer are actively developed to help patients fight cancer. Cancer immunotherapy, also known as immuno-oncology, is a form of cancer treatment that uses the power of the body’s own immune system to prevent, control, and eliminate cancer. Science magazine—America’s leading scientific journal—has deemed cancer immunotherapy the 2013 “Breakthrough of the Year,” beating out nine other contenders.

There are several types of immunotherapy, including: Non-specific immunotherapies, CAR T-cell therapy, cancer vaccines, checkpoint inhibitors, etc. Most cancer immunotherapy agents being developed or approved are engineered T cells targeting tumors or mostly antibody-based biologics that target the immune checkpoint cascade. The success of these biologics in the clinic is now inspiring the discovery and development of small molecules that act on intracellular targets affecting immuno-modulatory pathways in cancer. Small molecule agents as opposed to biologics that steer or enable the immune system to attack cancer cells, represent an emerging area of R&D focus in the oncology drug development industry. Small molecules are being investigated as stand-alone agents and synergistically with approved biologics because of the ability of small molecules to reach intracellular targets and the greater patient convenience offered by their oral bioavailability. The foundation for the pursuit of small molecule immune therapies for cancer is the wide spectrum of cells and their molecular pathways that are used by the immune system to suppress or enhance cellular immunity. Such novel immunotherapeutic approaches can either negate immune suppression in the tumor milieu or facilitate cytolytic lymphocyte responses to the tumor.

TargetMol’s Small Molecule Immuno-Oncology Compound Library carefully collects 340 bioactive compounds targeting intracellular pathways modulating the innate and adaptive immune response is a powerful tool for your research and drug discovery.

Pack Size Price/USD
100 μL * 10 mM (in DMSO) 7089.00
250 μL * 10 mM (in DMSO) 11733.00
1 mg 11733.00
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Product Description

  • A unique collection of 340 compounds acting on immune-oncology therapeutic targets can be used for high throughput and high content screening;
  • Targets include PD-1/PD-L1, HER2, STAT3, CTLA4, IDO, STING, CCR, CXCR, TLR, etc.
  • Detailed compound information with structure, target, and biological activity description;
  • NMR and HPLC validated to ensure high purity and quality.

Library Customization

Targetmol Compound Libraries can be highly customized! Learn More

Packaging And Storage

  • Powder or pre-dissolved DMSO solutions in 96/384 well plate with optional 2D barcode
  • Shipped with blue ice
Request Library Compound List (L2170)

Library Composition

TNF (55)
PI3K (51)
STAT (36)
TLR (29)
CXCR (23)
CCR (20)
EGFR (18)
TGF-beta/Smad (17)
IL Receptor (15)
IDO (14)
Adenosine Receptor (14)
ALK (13)
NF-κB (13)
HER (13)
BTK (12)
mTOR (10)
VEGFR (10)
JAK (7)
DNA-PK (7)
Epigenetic Reader Domain (7)
FLT (7)
CSF-1R (7)
Src (6)
c-Met/HGFR (5)
ERK (5)
FGFR (4)
HIV Protease (4)
p38 MAPK (4)
PD-1/PD-L1 (4)
c-Kit (4)
c-Fms (4)
Akt (4)
Arginase (4)
Autophagy (4)
Raf (4)
NOS (3)
Tyrosine Kinases (3)
Bcr-Abl (3)
Adrenergic Receptor (3)
Casein Kinase (3)
Caspase (3)
PDE (3)
MEK (3)
Indoleamine 2,3-Dioxygenase (IDO) (2)
NOD (2)
HDAC (2)
CDK (2)
COX (2)
AChR (2)
Apoptosis (2)
AMPK (2)
ROS (2)
S6 Kinase (2)
PKC (2)
PKM (1)
Potassium Channel (1)
PPAR (1)
PTEN (1)
Phosphatase (1)
PKA (1)
SARS-CoV (1)
Syk (1)
TAM Receptor (1)
UGT (1)
Tie-2 (1)
Trk receptor (1)
TRP/TRPV Channel (1)
Tyrosinase (1)
Antioxidant (1)
ATP Citrate Lyase (1)
Aurora Kinase (1)
BCL (1)
ACK (1)
5-HT Receptor (1)
Amino Acids and Derivatives (1)
Cysteine Protease (1)
Decarboxylase (1)
DNA Alkylation (1)
DNA/RNA Synthesis (1)
CFTR (1)
Chloride channel (1)
Carbonic Anhydrase (1)
HIF (1)
HSP (1)
Immunology & Inflammation related (1)
GluR (1)
hCE (1)
Hck (1)
MLK (1)
MMP (1)
LDL (1)
LTR (1)
MAPK (1)