Nature is a rich source of producing natural products by biosynthetic enzymes in a living organism, and most of which are structurally unique and difficult to be man-made synthesized. From 1981 to date, 79 (80%) out of 99 small molecule anticancer drugs are natural product-based/inspired, with 53 (53%) being either natural products or derived therefrom. Nature represents a major source of innovative therapeutic agents, and natural products still are recognized as an indispensable source for drug discovery. The 2015 Nobel Prize awarded to Professor Youyou Tu was to recognize and appreciate her pioneering discovery of artemisinin fromArtemisia annuaand clinical innovation in fighting against malaria, one of the top three diseases leading to the loss of people’s life.This award not only recognizes their achievements but spotlights the rich resource of natural products that show promise in medicine andhealth, attracting the interest of more scientists in the natural product discovery.
Currently screening hits from anatural product library then structurally optimizing hits to new drugs with therapeutic effects is an important way to the development of new drugs. Many natural product databases can provide data on structures concerning hundreds of thousands of natural product monomers, but most of which are not physically exist to be acquired.
In this library, TargetMol carefully select 16594 diverse natural products with free SDF data available to facilitate your research and development. It is a powerful tool for virtual screening, new drug development, and pharmacological study.