Compound Libraries PI3K-AKT-mTOR Compound Library

PI3K-AKT-mTOR Compound Library

Catalog No. L1300
  Library Compound List   Excel SDF

The PI3K/AKT/mTOR pathway is an intracellular signaling pathway important in regulating the cell cycle. Therefore, it is directly related to cellular quiescence, proliferation, cancer, and longevity. Phosphatidylinositol 3-kinase (PI3K), AKT, a serine/threonine protein kinase also known as protein kinase B (PKB), and mammalian target of rapamycin (mTOR) are 3 major nodes in the pathway. PI3K activation phosphorylates and activates AKT, localizing it in the plasma membrane. AKT can have a number of downstream effects such as activating CREB, inhibiting p27, localizing FOXO in the cytoplasm, activating PtdIns-3ps, and activating mTOR which can affect transcription of p70 or 4EBP1. mTOR is a component of the PI3K/AKT cell survival pathway that monitors the availability of nutrients, mitogenic signals and cellular energy and oxygen levels, a major regulator of the autophagic process, and alterations in components of the mTOR pathway have a major role in tumor progression. Therefore, mTOR is an appealing therapeutic target in many tumors. Encouraging data from preclinical studies have offered new opportunities to fully exploit the therapeutic potential of mTOR targeting in cancer.

The PI3K/Akt/mTOR Compound Library by TargetMol, containing 319 compounds targeting PI3K/Akt/mTOR signaling, can be used for high throughput screening and high content screening for new drugs.

Pack Size Price/USD
100 μL * 10 mM (in DMSO) 9129.00
250 μL * 10 mM (in DMSO) 12644.00
1 mg 12644.00
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Product Description

  • A unique collection of 319 compounds targeting PI3K/Akt/mTOR signaling for research in PI3K/Akt/mTOR signaling, and drug discovery in diseases involved with PI3K/Akt/mTOR signaling;
  • Effective tool for studying cell growth, proliferation, and apoptosis;
  • Targets include AKT, AMPK, mTOR, PI3K, ATR/ATM, etc;
  • Detailed compound information with structure, target, activity, IC50 value, and biological activity description;
  • Structurally diverse, medicinally active, and cell permeable;
  • NMR and HPLC validated to ensure high purity and quality;

Library Customization

Targetmol Compound Libraries can be highly customized! Learn More

Packaging And Storage

  • Powder or pre-dissolved DMSO solutions in 96/384 well plate with optional 2D barcode
  • Shipped with blue ice
Request Library Compound List (L1300)

Library Composition

PI3K (74)
mTOR (40)
Akt (25)
GSK-3 (25)
DNA-PK (21)
ATM/ATR (16)
S6 Kinase (12)
CDK (11)
AMPK (10)
PDK (9)
PKC (6)
PKA (5)
EGFR (5)
Autophagy (4)
Chk (4)
Carbonic Anhydrase (3)
FLT (3)
PTEN (3)
ROCK (3)
Src (3)
STAT (2)
P450 (2)
MEK (2)
Epigenetic Reader Domain (2)
ERK (2)
Casein Kinase (2)
Bcr-Abl (1)
BTK (1)
cholecystokinin (1)
c-Kit (1)
Dehydrogenase (1)
Apoptosis (1)
ALK (1)
ATP Citrate Lyase (1)
ATPase (1)
Aurora Kinase (1)
Estrogen/progestogen Receptor (1)
Fatty Acid Synthase (1)
FGFR (1)
GABA Receptor (1)
GluR (1)
c-Fms (1)
GST (1)
Hck (1)
HDAC (1)
Hedgehog/Smoothened (1)
HER (1)
HIF (1)
HIV Protease (1)
HSV (1)
IGF-1R (1)
Integrin (1)
JAK (1)
JNK (1)
lysosomal autophagy (1)
MAPK (1)
MELK (1)
MMP (1)
NF-κB (1)
PDE (1)
p38 MAPK (1)
Adrenergic Receptor (1)
PLK (1)
Potassium Channel (1)
Prostaglandin Receptor (1)
Syk (1)
TLR (1)
Tyrosine Kinases (1)
SGK (1)
Vitamin (1)