Compound Libraries Neurotransmitter Receptor Compound Library

Neurotransmitter Receptor Compound Library

Catalog No. L2610
  Library Compound List   Excel SDF

A neurotransmitter receptor (also known as a neuroreceptor) is a membrane receptor protein that is activated by a neurotransmitter. Chemicals on the outside of the cell, such as a neurotransmitter, can bump into its corresponding receptor in the membrane, bind and trigger other events to occur inside the cell. A neurotransmitter receptor is a class of receptors that specifically binds with neurotransmitters as opposed to other molecules. Neurotransmitter (NT) receptors are located on the surface of neuronal and glial cells.

There are two major types of neurotransmitter receptors: ionotropic and metabotropic. Ionotropic means that ions can pass through the receptor, whereas metabotropic means that a second messenger inside the cell relays the message (i.e. metabotropic receptors do not have channels). Metabotropic receptors are in fact G protein-coupled receptors. Ionotropic receptors are also called Ligand-gated ion channels and they can be excited by neurotransmitters like glutamate and aspartate. There are several major classes of neurotransmitters: Adrenergic, Dopaminergic, GABAergic, Glutaminergic, Histaminergic, Cholinergic, Opioid, Serotonergic, and Glycinergic.

In the brain, most drug targets consist of signaling proteins that go awry in central nervous system diseases, for example with autism in childhood, schizophrenia in adolescence, or Alzheimer's disease in old age. The aim of drug treatment is to correct the inappropriate behavior of these proteins and restore normal brain function. Understanding the effects of neurotransmitters is extremely important in therapeutics. All psychiatric drugs act by affecting neurotransmitters. Understanding their mechanism of action and adverse effects is key to developing new drugs for neurological diseases.

The TargetMol neurotransmitter receptor compound library contains 1290 CNS receptor ligands, which is ideal for screening or identifying recombinant orphan G protein-coupled receptors, target validation, secondary screening, validating new assays, and for routine pharmacological applications.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.
Pack Size Price/USD
30 μL * 10 mM (in DMSO) 9300.00
100 μL * 10 mM (in DMSO) 21200.00
250 μL * 10 mM (in DMSO) 32000.00
1 mg 32000.00
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Product Description

  • A unique collection of 1290 neurotransmitter receptor compounds, can be used for HTS and HCS screening;
  • Targets include 5-HT receptor, AChR, GABA receptor, dopamine receptor,Opiod receptor, Ionotropic Glutamatergic receptor, Metabotropic Glutamatergic receptor, Purinergic receptor, etc.;
  • Structurally diverse, medicinally active, and cell permeable;
  • Detailed information about compound structure, target, activity, etc.;
  • NMR and HPLC/LCMS validated to ensure high purity and quality.

Library Customization

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Packaging And Storage

  • Powder or pre-dissolved DMSO solutions in 96/384 well plate with optional 2D barcode
  • Shipped with blue ice
Request Library Compound List (L2610)

Library Composition

AChR (222)
5-HT Receptor (202)
Adrenergic Receptor (160)
Dopamine Receptor (126)
Histamine Receptor (86)
GABA Receptor (80)
GluR (63)
Opioid Receptor (50)
NMDAR (41)
Adenosine Receptor (24)
Norepinephrine (23)
Potassium Channel (15)
Sigma receptor (15)
Sodium Channel (11)
PDE (9)
Calcium Channel (9)
Monoamine Transporter (6)
HDAC (5)
iGluR (4)
P450 (4)
CaMK (4)
BACE (4)
Tyrosinase (4)
TNF (3)
Serotonin Transporter (3)
TRP/TRPV Channel (3)
Dehydrogenase (3)
Chloride channel (3)
Phospholipase (3)
DNA/RNA Synthesis (3)
MMP (2)
LDL (2)
GlyT (2)
Autophagy (2)
Beta Amyloid (2)
EGFR (2)
Endogenous Metabolite (2)
Adiponectin receptor (2)
ABC (2)
Androgen Receptor (2)
Antibacterial (2)
Antifection (2)
Transferase (1)
Syk (1)
TGF-beta/Smad (1)
PPAR (1)
Prostaglandin Receptor (1)
PTP1B (1)
Antifolate (1)
ATPase (1)
Aurora Kinase (1)
AChE (1)
BCL (1)
Bcr-Abl (1)
Amino Acids and Derivatives (1)
Cannabinoid Receptor (1)
Carbonic Anhydrase (1)
Caspase (1)
CAT (1)
CCR (1)
ERK (1)
Estrogen/progestogen Receptor (1)
FAK (1)
Gap Junction Protein (1)
GluCls (1)
Glucocorticoid Receptor (1)
Glucokinase (1)
COX (1)
DNA Alkylation (1)
DNA Methyltransferase (1)
DYRK (1)
GPR (1)
GRK (1)
GSK-3 (1)
GST (1)
HCV Protease (1)
HER (1)
Histone Methyltransferase (1)
HIV Protease (1)
lysosomal autophagy (1)
MEK (1)
IL Receptor (1)
Integrin (1)
MRP (1)
MT Receptor (1)
mTOR (1)
NF-κB (1)
NOD (1)
P2 Receptor (1)
PI3K (1)
PKA (1)
PKM (1)
Platelet aggregation (1)
PAFR (1)
Parasite (1)
PARP (1)