Compound Libraries Neural Regeneration Compound Library

Neural Regeneration Compound Library

Catalog No. L7700
  Library Compound List   Excel SDF

It is well known that neurological diseases that affect the brain or other components of the central nervous system are among the most devastating and complex conditions plaguing mankind today. For thousands of years, damage to the adult central nervous system (CNS) in humans has been regarded as an ‘ailment which cannot be treated’. In the adult mammalian CNS, most injured axons do not regenerate, reflecting a major hurdle for functional recovery after trauma. Numerous efforts over more than a century have been devoted to uncover the underlying mechanisms of regeneration failure. The discovery of neural and glial precursor cells in the adult brain and their ability to grow after injury trumped this assumption. However, in most cases, only small numbers of injured CNS axons can regenerate, consistent with the idea that lack of regeneration in the adult CNS is an intrinsic property of the injured neurons. Therefore, a major challenge has been to define the underlying cellular and molecular mechanisms that determine neuronal intrinsic regenerative ability, with the goal to construct a foundation for designing therapeutic neural repair strategies.

Many signaling pathways (including Ras homolog gene/Rho-associated coiled coil-forming protein kinase (Rho-ROCK), Notch, MAPK, Wnt/β-catenin, mTOR, and ephephrin) participate in and affect repair or regeneration of neurons and axons in the central nervous system. The cyclic adenosine monophosphate-protein kinase A (cAMP-PKA) and Rho-ROCK signaling pathways are key signal transduction pathways for regulating neural and axonal regeneration.

TargetMol collects 149 compounds related to neuroregeneration as Neuroregeneration Compound Library, which can be used for screening of drugs that promote axonal growth and regeneration.

Pack Size Price/USD
100 μL * 10 mM (in DMSO) 2384.00
250 μL * 10 mM (in DMSO) 4321.00
1 mg 4321.00
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Product Description

  • A unique collection of 149 neuroregeneration related compounds for high throughput and high content screening;
  • Targets several signaling pathways, such as Notch, MAPK, Wnt/β-catenin, mTOR, etc.;
  • Bioactivity and safety confirmed by pre-clinical research and clinical trials, and some of them are approved by FDA;
  • Detailed compound information with structure, target, activity, IC50 value, and biological activity description;
  • tructurally diverse, medicinally active, and cell permeable;
  • NMR and HPLC validated to ensure high purity and quality;

Library Customization

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Packaging And Storage

  • Powder or pre-dissolved DMSO solutions in 96/384 well plate with optional 2D barcode
  • Shipped with blue ice
Request Library Compound List (L7700)

Library Composition

mTOR (41)
PI3K (27)
p38 MAPK (25)
ERK (22)
Wnt/beta-catenin (15)
ROCK (14)
DNA-PK (13)
JNK (12)
Gamma-secretase (7)
Rho (6)
PKA (5)
Src (5)
CDK (5)
Ephrin Receptor (4)
Bcr-Abl (4)
S6 Kinase (4)
TGF-beta/Smad (3)
PKC (3)
Raf (3)
Aurora Kinase (3)
Akt (3)
c-Kit (3)
MEK (3)
FLT (2)
NF-κB (2)
Hck (2)
Epigenetic Reader Domain (2)
SGK (2)
PERK (2)
PPAR (1)
Tie-2 (1)
TNF (1)
Trk receptor (1)
Serine Protease (1)
Serine/threonin kinase (1)
Wnk (1)
EGFR (1)
c-Met/HGFR (1)
COX (1)
c-Fms (1)
ALK (1)
AMPK (1)
Apoptosis (1)
Apoptosis inducer (1)
Aromatase (1)
Autophagy (1)
BTK (1)
Carbonic Anhydrase (1)
HSV (1)
IGF-1R (1)
Immunology & Inflammation related (1)
IκB/IKK (1)
JAK (1)
GRK (1)
GSK-3 (1)
FGFR (1)
P450 (1)
LRRK2 (1)
lysosomal autophagy (1)