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Mitochondrial Targeting Compound Library

Catalog No. L5300

Themitochondrionis a double-membrane-bounddiscrete organellefound in mosteukaryoticorganisms, generating most of the cell's supply ofadenosine triphosphate(ATP) and controlling the cellular basal metabolic rate, called as the cell's powerhouses. In addition to supplying cellular energy, mitochondria are the major source of ROS (reactive oxygen species) that reflect the level of cellular oxidative stress and play an important role in mitochondria ROS signaling such as apoptosis, proliferation, and aging, etc. In addition, the fine modulation of mitochondrial calcium (Ca2+) homeostasis plays a fundamental role in many of the processes involving this organelle. Mitochondrial Ca2+accumulation is a tightly controlled process, in turn regulating functions as diverse asaerobic metabolismand induction ofcell death. Mitochondrial DNA mutations may lead to many mitochondrial metabolic disorders, and are thought to contribute to aging by promoting apoptosis. Mitochondria therefore represent an attractive drug target for metabolic diseases, neurodegeneration, or hyperproliferative diseases (cancer).A number of pre-clinical and clinical data have shown that mitochondria as drug targets have great potential. Small molecule drugs or biologics can act on mitochondria through various pathways including ETC inhibition, OXPHOS uncoupling, mitochondrial Ca2+modulation, and control of oxidative stressviadecrease or increase of mitochondrial ROS accumulation.

Mitochondrial Targeting Compound Library from TargetMol, a unique collection of 64 compounds targeting mitochondria, can be used for research in mitochondrial medicine and related target study.

Pack Size Price
100 μL * 10 mM (in DMSO) USD 1391.00
250 μL * 10 mM (in DMSO) USD 2365.00
1 mg USD 2365.00

Product Description

  • A unique collection of 64 promising or approved mitochondria-targeted compounds including Idebenone, the only approved drug targeting mitochondria, for research in mitochondrial medicine;
  • Targets include mitochondria related targets, such as ATPase, mitochondria-associated hexokinase, Bcl-2, NADP, etc. and inhibitors for the autophagy initiating factor, ULK1, also include other promising mitochondria-targeted compounds such as lonidamine, paclitaxel, etc;
  • Bioactivity and safety confirmed by pre-clinical research and clinical trials;
  • Detailed compound information with structure, target, activity, IC50 value, and biological activity description;
  • Structurally diverse, medicinally active, and cell permeable;
  • NMR and HPLC validated to ensure high purity and quality;

The compound library can be highly customized. You can select compounds, quantities, format (dry/solid or DMSO), plate map, and concentration to meet your specific requirement. Please check our Compound Library Instructions for more information.

Packaging and Storage

  • Powder or pre-dissolved DMSO solutions in 96 well plate with optional 2D barcode
  • Shipped with blue ice; Stable for One year as powder, 6 months at - 20 ° C in DMSO or 12months at -80 ° C in DMSO

Library Composition

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