Mitogen-activated protein kinases (MAPKs) are a highly conserved family of serine/threonine protein kinases involved in a variety of fundamental cellular processes such as proliferation, differentiation, motility, stress response, apoptosis, and survival. A broad range of extracellular stimuli including mitogens, cytokines, growth factors, and environmental stressors stimulate the activation of one or more MAPKK kinases (MAPKKKs) via receptor-dependent and -independent mechanisms. MAPKKKs then phosphorylate and activate a downstream MAPK kinase (MAPKK), which in turn phosphorylates and activates MAPKs.
The MAPK Inhibitor Library by TargetMol, containing 140 compounds targeting MAPK signaling, can be used for research in MAPK signaling, and drug screening for related diseases.
|100 μL * 10 mM (in DMSO)||2346.00|
|250 μL * 10 mM (in DMSO)||3992.00|