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Compound Libraries MAPK Inhibitor Library

MAPK Inhibitor Library

Catalog No. L1400
  Library Compound List   Excel SDF

Mitogen-activated protein kinases (MAPKs) are a highly conserved family of serine/threonine protein kinases involved in a variety of fundamental cellular processes such as proliferation, differentiation, motility, stress response, apoptosis, and survival. A broad range of extracellular stimuli including mitogens, cytokines, growth factors, and environmental stressors stimulate the activation of one or more MAPKK kinases (MAPKKKs) via receptor-dependent and -independent mechanisms. MAPKKKs then phosphorylate and activate a downstream MAPK kinase (MAPKK), which in turn phosphorylates and activates MAPKs.

The MAPK Inhibitor Library by TargetMol, containing 140 compounds targeting MAPK signaling, can be used for research in MAPK signaling, and drug screening for related diseases.

Pack Size Price/USD
100 μL * 10 mM (in DMSO) 2346.00
250 μL * 10 mM (in DMSO) 3992.00
1 mg 3992.00
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Product Description

  • A unique collection of 140 compounds targeting MAPK signaling for drug discovery in MAPK related diseases;
  • Bioactivity and safety confirmed by pre-clinical research and clinical trials, and some of them are approved by FDA;
  • Targets include ERK, JNK, MEK, p38, MAPK, Raf, RSK, MNK, etc;
  • Detailed compound information with structure, target, activity, IC50 value, and biological activity description;
  • Structurally diverse, medicinally active, and cell permeable;
  • NMR and HPLC validated to ensure high purity and quality;

Library Customization

Targetmol Compound Libraries can be highly customized! Learn More

Packaging and Storage

  • Powder or pre-dissolved DMSO solutions in 96 well plate with optional 2D barcode
  • Shipped with blue ice.
Request Library Compound List (L1400)

Library Composition

Raf (31)
p38 MAPK (25)
ERK (23)
MEK (18)
JNK (12)
MAPK (8)
VEGFR (7)
CDK (7)
Src (6)
NF-κB (5)
S6 Kinase (5)
c-Kit (5)
Aurora Kinase (4)
Bcr-Abl (4)
FLT (4)
EGFR (4)
PKC (4)
PDGFR (4)
FGFR (3)
AMPK (3)
AChR (2)
Akt (2)
COX (2)
c-RET (2)
DNA/RNA Synthesis (2)
IGF-1R (2)
MLK (2)
NOD (2)
PERK (2)
Ras (2)
Tyrosine Kinases (2)
Syk (2)
TGF-beta/Smad (2)
TNF (2)
TOPK (2)
Trk receptor (1)
STAT (1)
PPAR (1)
Prostaglandin Receptor (1)
Serine Protease (1)
SGK (1)
Sodium Channel (1)
Phosphatase (1)
PI3K (1)
PKA (1)
MMP (1)
MNK (1)
MPO (1)
GSK-3 (1)
Lipoxygenase (1)
IL Receptor (1)
Integrin (1)
IκB/IKK (1)
Estrogen/progestogen Receptor (1)
CSF-1R (1)
DNA Alkylation (1)
BTK (1)
c-Met/HGFR (1)
ALK (1)
ACK (1)
Apoptosis inducer (1)
Aromatase (1)
ASK (1)