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Compound Libraries Immunology/Inflammation Compound Library

Immunology/Inflammation Compound Library

Catalog No. L4700
  Library Compound List   Excel SDF

An autoimmune disorder occurs when the body's immune system attacks and destroys healthy body tissue by mistake. Areas often affected by autoimmune disorders include blood vessels, connective tissues, joints, and skin, etc. The chemical advances in the 19th–20th centuries brought about the development of non-steroidal anti-inflammatory drugs (NSAIDs). Although effective in the treatment of inflammatory diseases, NSAIDs have some undesirable and adverse effect, such as ulcers, kidney injury, and bleeding in the gastrointestinal tract. Although initially identified as anti-tumor molecule, TNF is now considered as a pleiotropic cytokine which plays a major role in immune or inflammatory responses. Consequently, anti-TNF biologics, which are designed to block the biological function of TNF, have been developed for the therapy of autoimmune inflammatory diseases. The success of biologics for autoimmune diseases coupled with rapid advances in basic research has validated many immunology-relevant signaling pathways and uncovered new intracellular molecules to target for potential new drug agents that can enter the cell. For example, many small chemicals or macrolide derivatives that can inhibit immunoproteasome, nucleus output proteins, NF-kB, and TNF-alpha have the potential to be developed as the drugs to treat the autoimmune inflammatory diseases and chronic inflammatory diseases.

Pack Size Price/USD
100 μL * 10 mM (in DMSO) 27014.00
250 μL * 10 mM (in DMSO) 45103.00
1 mg 45103.00
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Product Description

  • A unique collection of 2769 anti-inflammation compounds effective for high throughput screening and high content screening.
  • Bioactivity and safety confirmed by clinical research and trials, some of which are FDA approved;
  • Detailed compound information with structure, target, activity, IC50 value, and biological activity description;
  • Structurally diverse, medicinally active, and cell permeable;
  • NMR and HPLC validated to ensure high purity and quality;

Library Customization

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Packaging And Storage

  • Powder or pre-dissolved DMSO solutions in 96/384 well plate with optional 2D barcode
  • Shipped with blue ice
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Library Composition

COX (153)
Antibiotic (110)
Antibacterial (99)
EGFR (88)
NF-κB (87)
Histamine Receptor (83)
JAK (61)
AChR (57)
HDAC (53)
Antioxidant (51)
TNF (50)
IL Receptor (47)
Autophagy (47)
STAT (45)
DNA/RNA Synthesis (42)
Adrenergic Receptor (40)
5-HT Receptor (39)
ROS (39)
HIV Protease (38)
Glucocorticoid Receptor (38)
p38 MAPK (36)
Antiviral (35)
PDE (34)
Prostaglandin Receptor (32)
GR (32)
Antifungal (31)
Dehydrogenase (30)
P450 (30)
TLR (30)
Antifection (28)
Apoptosis (27)
Endogenous Metabolite (27)
IκB/IKK (26)
PPAR (26)
NOS (25)
ribosome (24)
PI3K (23)
Estrogen/progestogen Receptor (23)
CXCR (23)
HCV Protease (22)
Potassium Channel (22)
Src (22)
Topoisomerase (22)
Tyrosine Kinases (22)
VEGFR (21)
HER (21)
CCR (21)
CDK (18)
ERK (18)
Lipoxygenase (18)
NOD (17)
Sodium Channel (17)
AMPK (17)
Akt (17)
Caspase (16)
Epigenetic Reader Domain (16)
Reverse Transcriptase (16)
PKC (16)
Phospholipase (15)
MMP (15)
Dopamine Receptor (15)
GABA Receptor (15)
ATPase (15)
Calcium Channel (14)
GPR (14)
FLT (14)
Nrf2 (14)
Vitamin (14)
TRP/TRPV Channel (13)
Tyrosinase (13)
MRP (13)
Microtubule Associated (13)
Syk (13)
Parasite (12)
JNK (12)
AhR (12)
BTK (11)
FGFR (11)
MAO (11)
Norepinephrine (11)
RAAS (11)
Retinoid Receptor (11)
PDGFR (10)
Pim (10)
TGF-beta/Smad (10)
Sirtuin (10)
Serine Protease (10)
S1P Receptor (10)
mTOR (10)
LTR (10)
Immunology & Inflammation related (10)
BCL (10)
Bcr-Abl (10)
c-Kit (9)
HIF (9)
HSP (9)
IDO (9)
NADPH (9)
p53 (9)
STING (9)
Proteasome (9)
Phosphatase (8)
PARP (8)
MAPK (8)
DHFR (8)
Carbonic Anhydrase (8)
Apoptosis inducer (8)
Adenosine Receptor (8)
Wnt/beta-catenin (8)
Cannabinoid Receptor (7)
Beta Amyloid (7)
DNA Alkylation (7)
DNA gyrase (7)
HSV (7)
MEK (7)
Influenza Virus (7)
NO Synthase (7)
Opioid Receptor (7)
Proton pump (7)
PKA (6)
ROCK (6)
Integrin (6)
HMG-CoA Reductase (6)
GluR (6)
Cysteine Protease (6)
ALK (6)
Amino Acids and Derivatives (5)
Androgen Receptor (5)
Aurora Kinase (5)
c-RET (5)
CAT (5)
c-Fms (5)
Free radical scavengers (5)
Glucokinase (5)
HIF/HIF Prolyl-Hydroxylase (5)
HBV (5)
Nucleoside Antimetabolite/Analog (5)
NADPH-oxidase (5)
ROR (5)
S6 Kinase (5)
Thrombin (5)
PD-1/PD-L1 (5)
PGE Synthase (4)
P-gp (4)
Reactive Oxygen Species (4)
Reductase (4)
Raf (4)
Sigma receptor (4)
MPO (4)
P2 Receptor (4)
IGF-1R (4)
Hydroxylase (4)
LPA Receptor (4)
GSK-3 (4)
FXR (4)
DNA-PK (4)
Chloride channel (4)
Cell wall (4)
CSF-1R (4)
c-Myc (4)
Complement System (4)
Casein Kinase (4)
Arginase (4)
UGT (4)
Trk receptor (4)
Thyroid hormone receptor(THR) (3)
Annexin A (3)
ATM/ATR (3)
ATP Citrate Lyase (3)
ABC (3)
CaMK (3)
BACE (3)
cholecystokinin (3)
CFTR (3)
DPP-4 (3)
DNA Methyltransferase (3)
Hedgehog/Smoothened (3)
Histone Methyltransferase (3)
Liver X Receptor (3)
Interleukin Related (3)
NMDAR (3)
TAM Receptor (3)
SARS-CoV (3)
Protease-activated Receptor (3)
PAFR (3)
Ras (2)
PKM (2)
Platelet aggregation (2)
Telomerase (2)
Thrombopoietin Receptor (2)
SIK (2)
Serine/threonin kinase (2)
Rho (2)
LDL (2)
IAP (2)
Lipase (2)
Hippo pathway (2)
GST (2)
GluCls (2)
gp120/CD4 (2)
Glutathione reductase (2)
Gamma-secretase (2)
DprE1 (2)
E1/E2/E3 Enzyme (2)
EBI2/GPR183 (2)
FLAP (2)
Fatty Acid Synthase (2)
FAAH (2)
Chk (2)
cell cycle arrest (2)
advanced glycation end products (2)
Antifolate (2)
Aromatase (2)
Aryl Hydrocarbon Receptor (2)
VDA (2)
Tie-2 (1)
Xanthine Oxidase (1)
Virus Protease (1)
ASK (1)
Anti-infection (1)
Anion Exchanger (1)
Aminopeptidase (1)
ACAT (1)
Acetyl-CoA Carboxylase (1)
AChE (1)
Adiponectin receptor (1)
Acyltransferase (1)
c-Met/HGFR (1)
CRM1 (1)
Bradykinin Receptor (1)
cAMP (1)
BVDV (1)
Factor Xa (1)
FAK (1)
Endothelin Receptor (1)
Ferroptosis (1)
FOXO1 (1)
DUB (1)
Dynamin (1)
DYRK (1)
Discoidin Domain Receptor (DDR) (1)
DNA (1)
Decarboxylase (1)
Deubiquitinase (1)
Gap Junction Protein (1)
GHSR (1)
GlyT (1)
GPCR19 (1)
GTPase (1)
Haspin Kinase (1)
Hexokinase (1)
hCE (1)
Hck (1)
Histone Acetylation (1)
Hydrogenase (1)
Lipid (1)
LRRK2 (1)
lysosomal autophagy (1)
MALT (1)
Melatonin Receptor (1)
Mdm2 (1)
Mitochondrial Metabolism (1)
Mitophagy (1)
MLK (1)
IFNAR (1)
Integrase (1)
Indoleamine 2,3-Dioxygenase (IDO) (1)
Leukotriene Receptor (1)
Keap1-Nrf (1)
IRAK (1)
NKCC (1)
Neprilysin (1)
Neurokinin receptor (1)
MyD88 (1)
N-Acetylglucosaminyltransferase (1)
MTH1 (1)
MNK (1)
Monoamine Oxidase (1)
Monoamine Transporter (1)
Monocarboxylate transporter (1)
P2X Receptor (1)
OX Receptor (1)
PAD (1)
NPC1L1 (1)
NOD-like Receptor (NLR) (1)
RIP kinase (1)
RSV (1)
Serotonin Transporter (1)
SGLT (1)
Salt-Inducible Kinase (1)
Transferase (1)
transporter (1)
Survivin (1)
stilbene oxidase (1)
PTEN (1)
PTP1B (1)
RAR/RXR (1)
PAI-1 (1)
PDK (1)
PERK (1)
Phosphorylase (1)