Histamine, an important bioactive molecule, is derived from thedecarboxylationof theamino acidhistidine. Most histamine in the body is generated in granules inmast cellsand inskin, lung and gastrointestinal tract, playing a pivotal role in allergic and inflammatory reactions. Histamine acts as a neurotransmitter within the central nervous system. The histaminergic neurons that secrete histamine are localized in small regions of the hypothalamus, but those neurons send axons widely throughout the brain. Histamine appears to modulate a number of important processes in the brain, including wakefulness, cognitive ability andfood consumption. Currently four histamine receptors (H1R-H4R) have been cloned and identified, all of which are G protein-coupled receptors. These different receptors are expressed on different cell types and work through different intracellular signaling mechanisms. Post mortem studies have revealedalterations in histaminergic system in neurological and psychiatric diseases.
Melatoninis ahormone, produced by thepineal gland, a tinyendocrinegland situated at the center of the brain. Melatonin presents several ways of action in the regulation of seasonal reproduction, body weight and energy balance, antiaging, and promoting sleep.
|100 μL * 10 mM (in DMSO)||USD 1768.00|
|250 μL * 10 mM (in DMSO)||USD 2941.00|
|1 mg||USD 2941.00|
The compound library can be highly customized. You can select compounds, quantities, format (dry/solid or DMSO), plate map, and concentration to meet your specific requirement. Please check our Compound Library Instructions for more information.