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Compound Libraries HIF-1 Signaling Pathway Compound Library

HIF-1 Signaling Pathway Compound Library

Catalog No. L8500
  Library Compound List   Excel SDF

Cell signaling is part of any communication process that governs basic activities of cells and coordinates all cell actions. The ability of cells to perceive and correctly respond to their microenvironment is the basis of development, tissue repair, and immunity, as well as normal tissue homeostasis. Errors in signaling interactions and cellular information processing are responsible for diseases such as cancer, autoimmunity, and diabetes. By understanding cell signaling, diseases may be treated more effectively.

As a key regulator of the hypoxia response, hypoxia inducible factor-1 (HIF-1) has been attracting more attention from scientists. HIF-1 is an evolutionarily conserved transcription factor that functions as a main regulator of gene expression in response to hypoxia. HIF-1 is functionally heterodimeric, composed of HIF-1β and one of three α subunits (HIF-1α, HIF-2α, or HIF-3α). All subunits are part of the basic helix-loop-helix superfamily of transcription factors, but its activity is primarily controlled by cellular levels of the HIF-1α subunit. As a transcriptional factor, the heterodimer HIF-1 recognizes and binds to the consensus sequence 5’-(A/G) CGTG-3’ named hypoxia-responsive elements (HREs) to activate the transcriptional activity of target genes. To date, more than 100 direct target genes of HIF-1 have been uncovered, which have been shown to be functionally involved in tumor metastasis, angiogenesis, energy metabolism, cell differentiation and apoptosis.

Intensive studies have clearly established the hypoxia/HIF signaling pathway as a master regulator of the vascular system. Accordingly, it represents an important therapeutic target for vascular diseases and cancer. Pharmacologically increased HIF function may aid in the treatment of a wide range of diseases, as HIF has been shown to be essential for phenomena as diverse as immune function, cartilage formation, and wound healing. Conversely, inhibition of HIF function could also have many applications: increased levels of HIF are seen in many cancers as well as in some cardiovascular diseases, including stroke, heart attack, and pulmonary hypertension.

To meet the need of research in oxygen-sensing pathways, TargetMol collects 1071 HIF-1 related small chemicals,involving PI3K-AKT, MAPK, Ubiquitination signaling pathways and targets such as HIF, HIF Prolyl-Hydroxylase, E1/E2/E3 Enzyme, PI3K, MAPK, Proteasome, etc.

Pack Size Price/USD
100 μL * 10 mM (in DMSO) 19278.00
250 μL * 10 mM (in DMSO) 31855.00
1 mg 31855.00
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Product Description

  • A unique collection of 1071 HIF-1 related small chemicals can be used for drug discovery in ischemic disease and cancer and related mechanism studies;
  • Covers PI3K-AKT, MAPK, Ubiquitination signaling pathways and targets such as HIF, HIF Prolyl-Hydroxylase, E1/E2/E3 Enzyme, PI3K, MAPK, Proteasome, etc.
  • Part of them are in clinical trial phase or FDA approved;
  • Detailed compound information with structure, target, and biological activity description;
  • NMR and HPLC validated to ensure high purity and quality.

Library Customization

Targetmol Compound Libraries can be highly customized! Learn More

Packaging And Storage

  • Powder or pre-dissolved DMSO solutions in 96/384 well plate with optional 2D barcode
  • Shipped with blue ice
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Library Composition

PI3K (109)
COX (75)
NF-κB (71)
HDAC (59)
mTOR (58)
TNF (48)
p38 MAPK (45)
ERK (45)
Src (44)
Raf (41)
Akt (41)
GSK-3 (34)
AMPK (33)
MEK (30)
IL Receptor (26)
DNA-PK (26)
HIF (24)
Proteasome (24)
Sirtuin (23)
JNK (23)
ATM/ATR (21)
VEGFR (21)
ROS (21)
S6 Kinase (21)
TGF-beta/Smad (20)
CDK (20)
IκB/IKK (20)
DUB (19)
Bcr-Abl (17)
MAPK (17)
HSP (17)
p53 (17)
TLR (16)
Autophagy (13)
EGFR (13)
Caspase (12)
c-Kit (12)
E1/E2/E3 Enzyme (11)
Antioxidant (11)
Aurora Kinase (10)
NOD (10)
PKC (10)
HIF/HIF Prolyl-Hydroxylase (10)
Ras (10)
STAT (9)
PDGFR (9)
Apoptosis (9)
ALK (9)
FGFR (9)
FLT (9)
Gamma-secretase (9)
PDK (8)
Tyrosine Kinases (8)
PERK (7)
PDE (7)
PKA (7)
JAK (7)
Mdm2 (6)
P450 (6)
c-RET (6)
AChR (6)
Adrenergic Receptor (6)
Casein Kinase (6)
DNA/RNA Synthesis (5)
Endogenous Metabolite (5)
PPAR (5)
NOS (5)
p97 (5)
Trk receptor (5)
ROCK (5)
Potassium Channel (4)
Serine Protease (4)
Tyrosinase (4)
IGF-1R (4)
MMP (4)
MNK (4)
Lipoxygenase (4)
Cysteine Protease (4)
BTK (4)
Antiviral (4)
Antibacterial (3)
Calcium Channel (3)
Carbonic Anhydrase (3)
c-Fms (3)
BACE (3)
Beta Amyloid (3)
Dehydrogenase (3)
DNA Alkylation (3)
c-Met/HGFR (3)
Chk (3)
GABA Receptor (3)
Glucokinase (3)
LRRK2 (3)
Hck (3)
MPO (3)
MLK (3)
NADPH (3)
PARP (3)
SGK (3)
SIK (2)
S1P Receptor (2)
PTEN (2)
Wnt/beta-catenin (2)
TRP/TRPV Channel (2)
TOPK (2)
Syk (2)
TAM Receptor (2)
Phospholipase (2)
PI4K (2)
Nrf2 (2)
HER (2)
Histamine Receptor (2)
HIV Protease (2)
IAP (2)
Integrin (2)
Mitochondrial Metabolism (2)
Mitophagy (2)
GluR (2)
Glucocorticoid Receptor (2)
Epigenetic Reader Domain (2)
Estrogen/progestogen Receptor (2)
Chloride channel (2)
CSF-1R (2)
BCL (2)
ATP Citrate Lyase (2)
Apoptosis inducer (2)
Aromatase (2)
AhR (2)
ACK (1)
Adenosine Receptor (1)
Aminopeptidase (1)
Androgen Receptor (1)
Annexin A (1)
ASK (1)
Antibiotic (1)
Antifection (1)
ATPase (1)
5-HT Receptor (1)
BMI-1 (1)
CFTR (1)
cell cycle arrest (1)
Cannabinoid Receptor (1)
CXCR (1)
cholecystokinin (1)
DNA Methyltransferase (1)
DNA (1)
Dopamine Receptor (1)
DPP-4 (1)
FAK (1)
Fatty Acid Synthase (1)
Ferroptosis (1)
GR (1)
Glucagon Receptor (1)
Free radical scavengers (1)
MELK (1)
Microtubule Associated (1)
LTR (1)
lysosomal autophagy (1)
MAO (1)
Keap1-Nrf (1)
LDL (1)
Lipase (1)
IRAK (1)
Immunology & Inflammation related (1)
HSV (1)
Histone Methyltransferase (1)
Opioid Receptor (1)
PAFR (1)
PAI-1 (1)
PAK (1)
MRP (1)
Pim (1)
Prostaglandin Receptor (1)
PKM (1)
PLK (1)
P-gp (1)
Sodium Channel (1)
Topoisomerase (1)
RAAS (1)
Retinoid Receptor (1)
Reverse Transcriptase (1)
RIP kinase (1)
Salt-Inducible Kinase (1)
Serine/threonin kinase (1)