Compound Libraries GPCR Library Plus

GPCR Library Plus

Catalog No. L1580
  Library Compound List   Excel SDF

G-protein-coupled receptors (GPCRs) are the largest and most diverse group of membrane receptors in eukaryotes that detect molecules outside the cell and activate internal signal transduction pathways and, ultimately, cellular responses. GPCRs are involved in nearly every aspect of animal life, from early development and heart function to neuronal activity. Mutations in GPCRs are linked to a number of human diseases. GPCRs are an important drug target and approximately 34% of the marketed drugs target 108 members of this family, with an additional 66 receptors targeted by agents that are/were in clinical trials. GPCR-based drug discovery remains active campaigns in major pharmaceutical companies. To date more than 140 orphan GPCRs, whose endogenous ligands are unknown, are the focus of an intense drug discovery effort in many programs.

GPCR Compound Library Plus from TargetMol, a focused small molecule library, was developed against particular GPCRs containing 403 GPCR-active agents with IC50 less than 3.5 μM for GPCR drug discovery, target identification, and research in signaling pathway.

Pack Size Price/USD
100 μL * 10 mM (in DMSO) 6008.00
250 μL * 10 mM (in DMSO) 10214.00
1 mg 10214.00
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Product Description

  • Quantity: well-chosen 403 GPCR targeting compounds with unique structures;
  • High bioactivity: All compounds with IC50 below 3.5 μM;
  • Targets include 29 various GPCR subtypes;
  • Detailed compound information with structure, target, activity, IC50 value, and biological activity description;
  • HNMR/LCMS validated to ensure high purity and quality;
  • A powerful tool for GPCR drug development and target identification.

Library Customization

Targetmol Compound Libraries can be highly customized! Learn More

Packaging And Storage

  • Powder or pre-dissolved DMSO solutions in 96/384 well plate with optional 2D barcode
  • Shipped with blue ice
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