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Compound Libraries Fluorochemical Library

Fluorochemical Library

Catalog No. L5100
  Library Compound List   Excel SDF

Fluorine atoms have a unique combination of electronic and physical properties. As such, when incorporated into active pharmaceutical ingredients (APIs), fluorine atoms often influence their protein binding affinity and lipophilicity but not the shape of the resulting fluorochemicals. Fluorination can thus significantly impact the bioavailability or metabolic stability of drug substances.

The pivotal role that the element fluorine plays in modulating the properties of bioactive molecules is reflected by the growth of its presence in approved drugs, as evidenced by the fact that between 15% to 20% of all medicines and agrochemicals on the market contain at least one fluorine atom in their structure. As of 2009, the FDA had approved >140 fluorine-containing drugs, such as fluorouracil, Miglitol, Gemcitabine, Sofosbuvir, atorvastatin, fluoxetine, ciprofloxacin, etc.

The judicious introduction of fluorine into a molecule can productively influence conformation, pKa, intrinsic potency, membrane permeability, metabolic pathways, and pharmacokinetic properties.

Nowadays, the application of specialty fluorochemicals in the pharmaceutical industry has been increasingly widespread. TargetMol’s fluorochemical library has become an effective tool for developing new anticancer drugs, anesthetics, antidepressants, antifungals, antiviral drugs, antibiotics, cholesterol lowering agents, and anti-inflammatory agents. In addition, in agricultural uses, the addition of fluorine to many agricultural herbicides, pesticides, and fungicides improves the potency and therefore reduces the required application rate of these substances.

Pack Size Price/USD
100 μL * 10 mM (in DMSO) 9745.00
250 μL * 10 mM (in DMSO) 16184.00
1 mg 16184.00
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Product Description

  • A unique collection of 586 fluorochemicals that can be used for high through-put screening (HTS) and high content screening (HCS);
  • Bioactivity and safety confirmed by pre-clinical research and clinical trials, and some of them are approved by FDA;
  • Detailed compound information with structure, target, activity, IC50 value, and biological activity description;
  • NMR and HPLC validated to ensure high purity and quality;
  • All compounds are in stock.

Library Customization

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Packaging and Storage

  • Powder or pre-dissolved DMSO solutions in 96 well plate with optional 2D barcode
  • Shipped with blue ice.
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Library Composition

VEGFR (29)
EGFR (27)
5-HT Receptor (20)
Raf (20)
Topoisomerase (19)
FLT (19)
DNA/RNA Synthesis (19)
PI3K (18)
c-Kit (17)
Dopamine Receptor (16)
c-Met/HGFR (15)
PDGFR (14)
p38 MAPK (13)
GR (13)
MEK (12)
COX (12)
Dehydrogenase (12)
Src (11)
Potassium Channel (10)
FGFR (10)
Androgen Receptor (10)
Bcr-Abl (10)
JAK (9)
DNA gyrase (8)
Tyrosine Kinases (8)
Syk (7)
S6 Kinase (7)
Gamma-secretase (7)
Aurora Kinase (7)
Adrenergic Receptor (7)
ALK (6)
GABA Receptor (6)
FAK (6)
GluR (6)
GPR (6)
HIV Protease (6)
mTOR (6)
Phospholipase (6)
TAM Receptor (6)
HDAC (5)
LRRK2 (5)
ERK (5)
DUB (5)
c-RET (5)
BTK (5)
CDK (5)
ATPase (4)
CCR (4)
Caspase (4)
Calcium Channel (4)
Beta Amyloid (4)
AChR (4)
Antibiotic (4)
CFTR (4)
Cysteine Protease (4)
DPP-4 (4)
Estrogen/progestogen Receptor (4)
Histamine Receptor (4)
IκB/IKK (4)
HER (4)
HMG-CoA Reductase (4)
PARP (4)
PDE (4)
NMDAR (4)
Trk receptor (4)
Serine Protease (4)
PLK (4)
Sodium Channel (4)
PPAR (4)
Protease-activated Receptor (3)
Proton pump (3)
PYK2 (3)
Reductase (3)
TRP/TRPV Channel (3)
transporter (3)
Neurokinin 1 (3)
MRP (3)
Liver X Receptor (3)
P2 Receptor (3)
Pim (3)
PKA (3)
HSP (3)
HCV Protease (3)
GRK (3)
GSK-3 (3)
IGF-1R (3)
IL Receptor (3)
Epigenetic Reader Domain (3)
DprE1 (3)
DNA-PK (3)
CRM1 (3)
CSF-1R (3)
Antifection (3)
Annexin A (3)
BACE (3)
CETP (3)
Carbonic Anhydrase (2)
Casein Kinase (2)
Antibacterial (2)
Akt (2)
ATM/ATR (2)
Antifungal (2)
FXR (2)
Lipase (2)
MAO (2)
MAPK (2)
Mdm2 (2)
Hydroxylase (2)
IAP (2)
IDO (2)
HIF (2)
Hedgehog/Smoothened (2)
Phosphatase (2)
OX Receptor (2)
PERK (2)
Monocarboxylate transporter (2)
NOS (2)
P450 (2)
STAT (2)
Tie-2 (2)
TNF (2)
ROCK (2)
ROS (2)
S1P Receptor (2)
SGLT (2)
Sigma receptor (2)
Sirtuin (1)
Reverse Transcriptase (1)
Rho (1)
Prostaglandin Receptor (1)
Transferase (1)
TGF-beta/Smad (1)
Wnk (1)
Wnt/beta-catenin (1)
UGT (1)
p53 (1)
PAI-1 (1)
NPC1L1 (1)
Nrf2 (1)
NOD (1)
Norepinephrine (1)
Microtubule Associated (1)
Monoamine Transporter (1)
MTH1 (1)
PGE Synthase (1)
PDK (1)
PED (1)
Phosphorylase (1)
PKM (1)
HIF/HIF Prolyl-Hydroxylase (1)
HBV (1)
GNRH Receptor (1)
lysosomal autophagy (1)
Histone Methyltransferase (1)
Immunology & Inflammation related (1)
Integrase (1)
JNK (1)
Kinesin (1)
LHRH (1)
LIM Kinase (1)
FOXO1 (1)
Glucagon Receptor (1)
GluCls (1)
Glucocorticoid Receptor (1)
Glucokinase (1)
E1/E2/E3 Enzyme (1)
FAAH (1)
Chk (1)
Chloride channel (1)
c-Myc (1)
Dehydrogenase inhibitor (1)
DNA Alkylation (1)
ASK (1)
ACK (1)
Adenosine Receptor (1)
Amino Acids and Derivatives (1)
AhR (1)
CaSR (1)
BCL (1)
Autophagy (1)
Bombesin Receptor (1)
Cannabinoid Receptor (1)