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Compound Libraries Fluorochemical Library

Fluorochemical Library

Catalog No. L5100
  Library Compound List   Excel SDF

Fluorine atoms have a unique combination of electronic and physical properties. As such, when incorporated into active pharmaceutical ingredients (APIs), fluorine atoms often influence their protein binding affinity and lipophilicity but not the shape of the resulting fluorochemicals. Fluorination can thus significantly impact the bioavailability or metabolic stability of drug substances.

The pivotal role that the element fluorine plays in modulating the properties of bioactive molecules is reflected by the growth of its presence in approved drugs, as evidenced by the fact that between 15% to 20% of all medicines and agrochemicals on the market contain at least one fluorine atom in their structure. As of 2009, the FDA had approved >140 fluorine-containing drugs, such as fluorouracil, Miglitol, Gemcitabine, Sofosbuvir, atorvastatin, fluoxetine, ciprofloxacin, etc.

The judicious introduction of fluorine into a molecule can productively influence conformation, pKa, intrinsic potency, membrane permeability, metabolic pathways, and pharmacokinetic properties.

Nowadays, the application of specialty fluorochemicals in the pharmaceutical industry has been increasingly widespread. TargetMol’s fluorochemical library has become an effective tool for developing new anticancer drugs, anesthetics, antidepressants, antifungals, antiviral drugs, antibiotics, cholesterol lowering agents, and anti-inflammatory agents. In addition, in agricultural uses, the addition of fluorine to many agricultural herbicides, pesticides, and fungicides improves the potency and therefore reduces the required application rate of these substances.

Pack Size Price/USD
100 μL * 10 mM (in DMSO) 9745.00
250 μL * 10 mM (in DMSO) 16184.00
1 mg 16184.00
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Product Description

  • A unique collection of 586 fluorochemicals that can be used for high through-put screening (HTS) and high content screening (HCS);
  • Bioactivity and safety confirmed by pre-clinical research and clinical trials, and some of them are approved by FDA;
  • Detailed compound information with structure, target, activity, IC50 value, and biological activity description;
  • NMR and HPLC validated to ensure high purity and quality;
  • All compounds are in stock.

Library Customization

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Packaging And Storage

  • Powder or pre-dissolved DMSO solutions in 96/384 well plate with optional 2D barcode
  • Shipped with blue ice
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Library Composition

VEGFR (29)
EGFR (25)
Raf (23)
FLT (19)
c-Kit (19)
5-HT Receptor (19)
DNA/RNA Synthesis (17)
PI3K (17)
Glucocorticoid Receptor (16)
PDGFR (15)
c-Met/HGFR (15)
Dopamine Receptor (15)
Bcr-Abl (14)
Src (14)
Topoisomerase (13)
GR (13)
p38 MAPK (12)
MEK (12)
Dehydrogenase (12)
COX (11)
FGFR (11)
Androgen Receptor (11)
Potassium Channel (10)
JAK (9)
Aurora Kinase (8)
Gamma-secretase (8)
S6 Kinase (8)
Tyrosine Kinases (8)
TAM Receptor (7)
ALK (7)
Antibiotic (6)
Antifungal (6)
Adrenergic Receptor (6)
CDK (6)
c-RET (6)
DNA gyrase (6)
GluR (6)
GABA Receptor (6)
GPR (6)
HDAC (6)
Phospholipase (6)
PPAR (5)
Syk (5)
Trk receptor (5)
HER (5)
HCV Protease (5)
HIV Protease (5)
LRRK2 (5)
mTOR (5)
PDE (5)
FAK (5)
DUB (5)
ERK (5)
Estrogen/progestogen Receptor (5)
BTK (5)
Calcium Channel (5)
ATPase (5)
Antibacterial (4)
Beta Amyloid (4)
CFTR (4)
Caspase (4)
DPP-4 (4)
Epigenetic Reader Domain (4)
Cysteine Protease (4)
CCR (4)
PARP (4)
NMDAR (4)
HMG-CoA Reductase (4)
HSP (4)
IκB/IKK (4)
Tie-2 (4)
Sodium Channel (4)
PLK (4)
Serine Protease (4)
Protease-activated Receptor (3)
Proton pump (3)
PYK2 (3)
Reductase (3)
transporter (3)
Liver X Receptor (3)
Hydroxylase (3)
IDO (3)
IGF-1R (3)
Histamine Receptor (3)
GRK (3)
GSK-3 (3)
MAO (3)
MRP (3)
Pim (3)
PKA (3)
P2 Receptor (3)
CRM1 (3)
CSF-1R (3)
FXR (3)
DprE1 (3)
CETP (3)
BACE (3)
Antifection (3)
AChR (3)
Annexin A (3)
Adenosine Receptor (2)
Akt (2)
ATM/ATR (2)
Autophagy (2)
Carbonic Anhydrase (2)
Casein Kinase (2)
FAAH (2)
Ephrin Receptor (2)
Chloride channel (2)
DNA-PK (2)
Discoidin Domain Receptor (DDR) (2)
Monocarboxylate transporter (2)
OX Receptor (2)
P450 (2)
PERK (2)
MAPK (2)
Mdm2 (2)
NOS (2)
NAMPT (2)
Neurokinin receptor (2)
HIF (2)
Hedgehog/Smoothened (2)
IL Receptor (2)
IAP (2)
Lipase (2)
ROCK (2)
ROS (2)
S1P Receptor (2)
STAT (2)
SGLT (2)
Sigma receptor (2)
TNF (2)
TRP/TRPV Channel (2)
UGT (1)
Transferase (1)
Sirtuin (1)
TGF-beta/Smad (1)
Serine/threonin kinase (1)
Serotonin Transporter (1)
Reverse Transcriptase (1)
Rho (1)
Prostaglandin Receptor (1)
Wnk (1)
Wnt/beta-catenin (1)
JNK (1)
Kinesin (1)
LHRH (1)
LIM Kinase (1)
Immunology & Inflammation related (1)
Influenza Virus (1)
Integrase (1)
Integrin (1)
HIF/HIF Prolyl-Hydroxylase (1)
Histone Acetyltransferase (1)
Histone Methyltransferase (1)
GTPase (1)
Guanylate cyclase (1)
HBV (1)
GNRH Receptor (1)
Glucokinase (1)
Neuropeptide Y Receptor (1)
NPC1L1 (1)
Nrf2 (1)
NOD (1)
lysosomal autophagy (1)
MTH1 (1)
Monoamine Transporter (1)
PGE Synthase (1)
Phosphatase (1)
PDK (1)
PED (1)
p53 (1)
PAI-1 (1)
PAK (1)
Parasite (1)
DNA Alkylation (1)
Dehydrogenase inhibitor (1)
c-Myc (1)
E1/E2/E3 Enzyme (1)
Glucagon Receptor (1)
GluCls (1)
FOXO1 (1)
CaSR (1)
Chk (1)
BCL (1)
Bombesin Receptor (1)
Cannabinoid Receptor (1)
ASK (1)
ACK (1)
AhR (1)