Cart
Compound Libraries Ferroptosis Compound Library

Ferroptosis Compound Library

Catalog No. L8700
  Library Compound List   Excel SDF

Ferroptosis is a type of programmed cell death dependent on iron and characterized by the accumulation of lipid peroxides, and is genetically, biochemically and morphologically distinct from other forms of regulated cell death such as apoptosis, necroptosis, and autophagic cell death. It is characterized morphologically by the presence of smaller than normal mitochondria with condensed mitochondrial membrane densities, reduction or vanishing of mitochondria crista, and outer mitochondrial membrane rupture. Misregulated ferroptosis has been implicated in multiple physiological and pathological processes, including cancer cell death, neurotoxicity, neurodegenerative diseases, acute renal failure, drug-induced hepatotoxicity, hepatic and heart ischemia/reperfusion injury, and T-cell immunity. Understanding the molecular mechanisms and signaling pathways of ferroptosis may provide new diagnostic and therapeutic approaches to regulate cell survival and death in human disease.

TargetMol collects 694 compounds related to ferroptosis signaling pathway with targets including GPX4, System Xc−, HSPB1, NRF2, VDAC2/3, Ras, TFR1, NOX, p53, CARS, ROS, SLC7A11, etc. Iron chelators and lipid peroxidation inhibitors are also included in this library.

Pack Size Price/USD
100 μL * 10 mM (in DMSO) 11555.00
250 μL * 10 mM (in DMSO) 18976.00
1 mg 18976.00
Request Library
Get quote

Product Description

  • A unique collection of 694 ferroptosis signaling pathway related compounds, a powerful tool for new target identification, drug discovery, and mechanism study;
  • Covers various targets such as GPX4, ROS, p53, Nrf2, etc.;
  • Some compounds are FDA approved;
  • Detailed compound information with structure, target, and biological activity description;
  • NMR and HPLC validated to ensure high purity and quality.

Library Customization

Targetmol Compound Libraries can be highly customized! Learn More

Packaging And Storage

  • Powder or pre-dissolved DMSO solutions in 96/384 well plate with optional 2D barcode
  • Shipped with blue ice
Request Library Compound List (L8700)

Library Composition

Antioxidant (94)
ROS (40)
NF-κB (34)
p53 (23)
COX (18)
Endogenous Metabolite (18)
TNF (17)
Nrf2 (15)
P450 (14)
Apoptosis (14)
PPAR (13)
Mdm2 (12)
Autophagy (12)
Calcium Channel (10)
Antibacterial (10)
HMG-CoA Reductase (10)
MMP (9)
AChR (9)
STAT (9)
Antibiotic (8)
ERK (8)
Ferroptosis (8)
DNA/RNA Synthesis (8)
IL Receptor (8)
HIF (7)
p38 MAPK (7)
Dehydrogenase (7)
Estrogen/progestogen Receptor (7)
5-HT Receptor (7)
Akt (7)
Tyrosinase (7)
AMPK (6)
BCL (6)
DPP-4 (6)
NOS (6)
PKC (6)
Histamine Receptor (6)
Lipoxygenase (6)
MAO (5)
IκB/IKK (5)
JNK (5)
EGFR (5)
Dopamine Receptor (5)
Glucokinase (5)
Apoptosis inducer (5)
Antifection (5)
VEGFR (5)
Vitamin (5)
Sirtuin (5)
TGF-beta/Smad (4)
Trk receptor (4)
Adrenergic Receptor (4)
BACE (4)
Beta Amyloid (4)
GABA Receptor (4)
Caspase (4)
HIV Protease (4)
NADPH (4)
Prostaglandin Receptor (4)
PI3K (4)
RAAS (4)
Parasite (3)
PARP (3)
mTOR (3)
MEK (3)
GPX (3)
Epigenetic Reader Domain (3)
Free radical scavengers (3)
Bcr-Abl (3)
Carbonic Anhydrase (3)
ATPase (3)
ALK (3)
Wnt/beta-catenin (3)
Potassium Channel (3)
Src (3)
Reductase (3)
Reverse Transcriptase (2)
ribosome (2)
SGLT (2)
UGT (2)
TRP/TRPV Channel (2)
TLR (2)
transporter (2)
Amino Acids and Derivatives (2)
AhR (2)
Antifungal (2)
Antiviral (2)
Aromatase (2)
CaMK (2)
FGFR (2)
GluR (2)
cell cycle arrest (2)
DNA Alkylation (2)
Cysteine Protease (2)
MAPK (2)
Glucocorticoid Receptor (2)
Mitochondrial Metabolism (2)
HDAC (2)
HSP (2)
HSV (2)
Influenza Virus (2)
NMDAR (2)
NOD (2)
Raf (2)
PKA (2)
Proteasome (2)
PKM (2)
PDGFR (2)
P-gp (1)
Phosphatase (1)
Phospholipase (1)
Platelet aggregation (1)
PLK (1)
Proton pump (1)
Ras (1)
NOD-like Receptor (NLR) (1)
NO Synthase (1)
NPC1L1 (1)
Opioid Receptor (1)
PDE (1)
p97 (1)
OX Receptor (1)
P2X Receptor (1)
Integrin (1)
IRAK (1)
Immunology & Inflammation related (1)
Keap1-Nrf (1)
LDL (1)
Lipid (1)
Hydrogenase (1)
IAP (1)
Hedgehog/Smoothened (1)
Hexokinase (1)
Mitophagy (1)
MPO (1)
NADPH-oxidase (1)
Liver X Receptor (1)
lysosomal autophagy (1)
Melatonin Receptor (1)
Microtubule Associated (1)
DUB (1)
DNA gyrase (1)
CFTR (1)
Chloride channel (1)
c-Kit (1)
c-Met/HGFR (1)
c-Myc (1)
CDK (1)
CXCR (1)
Glutathione reductase (1)
Gamma-secretase (1)
GR (1)
GSK-3 (1)
HCV Protease (1)
FLT (1)
FXR (1)
cAMP (1)
Casein Kinase (1)
BMI-1 (1)
BVDV (1)
ASK (1)
ATM/ATR (1)
ATP Citrate Lyase (1)
Aurora Kinase (1)
Androgen Receptor (1)
Annexin A (1)
advanced glycation end products (1)
Adenosine Receptor (1)
Thioredoxin (1)
Thyroid hormone receptor(THR) (1)
Topoisomerase (1)
Transferase (1)
Xanthine Oxidase (1)
Wnk (1)
Tyrosine Kinases (1)
Sigma receptor (1)
Serine Protease (1)
ROR (1)
Retinoid Receptor (1)
Sodium Channel (1)
Somatostatin (1)
stilbene oxidase (1)
Syk (1)
Telomerase (1)