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Compound Libraries Drug-induced Liver Injury (DILI) Compound Library

Drug-induced Liver Injury (DILI) Compound Library

Catalog No. L5510
  Library Compound List   Excel SDF

Adverse drug events such as cardiotoxicity, hepatotoxicity and other organ toxicities, keep surfacing in the clinic and idiosyncratic drug toxicity continues to haunt the drug development process. Drug-induced liver injury (DILI) is common and nearly all classes of medications can cause liver disease. Although cardiotoxicity remains one of the main reasons for drug development termination, both during pre-clinical and clinical stages, DILI is the most common reason cited for withdrawal of an approved drug. The reason for this most likely lies in the fact that significant advancement in understanding the mechanistic basis of cardiotoxicity but the imperfect prediction of DILI risk.

DILI is thought to occur via several different mechanisms. Among these are direct impairment of the structural and functional integrity of the liver (e.g., mitochondrial dysfunction); production of a metabolite that alters hepatocellular structure and function; production of a reactive drug metabolite that binds to hepatic proteins to produce new antigenic drug-protein adducts, which are targeted by hosts’ defenses (the hapten hypothesis); and initiation of a systemic hypersensitivity response (i.e., drug allergy) that damages the liver.

TargetMol’s Drug-induced Liver Injury Compound Library collects 939 hepatotoxicity causing compounds, including anti-cancer drugs, antibiotics, antituberculosis agents, antiretrovirals, antiepileptic agents, and cardiac medications, etc. It is not only a powerful tool for DILI research and other drug toxicities but is of crucial value in understanding the mechanisms of DILI, identifying biomarkers for early DILI prediction, and allowing timely recognition during drug development, thus finally achieving successful DILI prevention and assessment in the pre-marketing phase.

Pack Size Price/USD
100 μL * 10 mM (in DMSO) 14077.00
250 μL * 10 mM (in DMSO) 23372.00
1 mg 23372.00
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Product Description

  • A unique collection of 939 hepatotoxicity causing compounds, a powerful tool for drug toxicity study, can be used for HTS and HCS screening;
  • Include anti-cancer drugs, antibiotics, antituberculotic agents, antiretrovirals, antiepileptic agents, and cardiac medications, etc.;
  • Diversified in toxicities: Steatosis, Mitochondrial toxicity, cholestasis, drug allergy (hypersensitivity), etc.;
  • NMR and HPLC validated to ensure high purity and quality.

Library Customization

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Packaging And Storage

  • Powder or pre-dissolved DMSO solutions in 96/384 well plate with optional 2D barcode
  • Shipped with blue ice
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Library Composition

Antibacterial (172)
Adrenergic Receptor (46)
AChR (43)
5-HT Receptor (42)
DNA/RNA Synthesis (39)
Dopamine Receptor (37)
COX (28)
Antibiotic (27)
Histamine Receptor (25)
Topoisomerase (23)
Sodium Channel (20)
Potassium Channel (20)
VEGFR (19)
PDGFR (17)
RAAS (17)
Microtubule Associated (17)
Calcium Channel (17)
HIV Protease (16)
c-Kit (15)
Dehydrogenase (13)
Estrogen/progestogen Receptor (13)
GABA Receptor (13)
EGFR (12)
DNA Alkylation (12)
P450 (12)
ribosome (11)
Bcr-Abl (11)
Autophagy (11)
HDAC (11)
Norepinephrine (11)
Reverse Transcriptase (10)
PDE (10)
Raf (9)
MRP (9)
MAO (9)
FLT (9)
Antifection (9)
Androgen Receptor (9)
ALK (8)
HMG-CoA Reductase (8)
Opioid Receptor (8)
PPAR (8)
Tyrosine Kinases (8)
Src (8)
Retinoid Receptor (7)
PI3K (7)
ROS (7)
HCV Protease (7)
NMDAR (7)
Aromatase (7)
CDK (7)
c-RET (6)
Antifungal (6)
NF-κB (6)
MEK (6)
FGFR (6)
Glucocorticoid Receptor (6)
PKC (6)
TNF (5)
GluR (5)
Antiviral (5)
CaMK (5)
c-Met/HGFR (5)
Chloride channel (5)
DNA Methyltransferase (4)
BTK (4)
Antioxidant (4)
GR (4)
Lipoxygenase (4)
mTOR (4)
NADPH (4)
Trk receptor (4)
TAM Receptor (4)
Vitamin (4)
Parasite (4)
PARP (4)
Proteasome (4)
Proton pump (3)
Reductase (3)
TGF-beta/Smad (3)
Thrombin (3)
TLR (3)
Transferase (3)
MMP (3)
MPO (3)
Influenza Virus (3)
JAK (3)
GST (3)
HER (3)
HSV (3)
Hydroxylase (3)
AhR (3)
Akt (3)
ABC (3)
Carbonic Anhydrase (3)
Apoptosis (3)
ATPase (3)
DNA gyrase (3)
Endothelin Receptor (3)
Factor Xa (3)
Fatty Acid Synthase (3)
AMPK (3)
CAT (2)
DHFR (2)
DPP-4 (2)
BCL (2)
Apoptosis inducer (2)
Adenosine Receptor (2)
Aminopeptidase (2)
HSP (2)
Hedgehog/Smoothened (2)
Histone Methyltransferase (2)
HBV (2)
GNRH Receptor (2)
GPR (2)
ERK (2)
Integrin (2)
MAPK (2)
Melatonin Receptor (2)
Nrf2 (2)
MT Receptor (2)
Tyrosinase (2)
Thyroid hormone receptor(THR) (2)
Telomerase (2)
STAT (2)
Syk (2)
UGT (2)
Rho (2)
S1P Receptor (2)
Serine Protease (2)
P2 Receptor (2)
Prostaglandin Receptor (2)
Protease-activated Receptor (1)
Platelet aggregation (1)
PLK (1)
PKA (1)
P-gp (1)
Phospholipase (1)
Serine/threonin kinase (1)
Serotonin Transporter (1)
Sigma receptor (1)
Sirtuin (1)
Smo (1)
S6 Kinase (1)
SARS-CoV (1)
ROCK (1)
ROR (1)
Vasopressin Receptor (1)
Somatostatin (1)
TRP/TRPV Channel (1)
Monoamine Oxidase (1)
Monoamine Transporter (1)
NADPH-oxidase (1)
Neurokinin receptor (1)
Nucleoside Antimetabolite/Analog (1)
OAT (1)
NPC1L1 (1)
NKCC (1)
Mitophagy (1)
Mdm2 (1)
LTR (1)
lysosomal autophagy (1)
IκB/IKK (1)
Integrase (1)
JNK (1)
LDL (1)
Lipid (1)
Free radical scavengers (1)
FXR (1)
GlyT (1)
Glucokinase (1)
GRK (1)
GSK-3 (1)
Hck (1)
Guanylate cyclase (1)
Histone Demethylase (1)
Hexokinase (1)
HIF (1)
Hydrogenase (1)
IAP (1)
IGF-1R (1)
IL Receptor (1)
Annexin A (1)
ACK (1)
Amino Acids and Derivatives (1)
ATP Citrate Lyase (1)
Aurora Kinase (1)
Caspase (1)
Cannabinoid Receptor (1)
BVDV (1)
Beta-Secretase (1)
DUB (1)
DNA Alkylator/Crosslinker (1)
Ferroptosis (1)
FAK (1)
Ephrin Receptor (1)
Epigenetic Reader Domain (1)
Electron transport (1)
Endogenous Metabolite (1)
CSF-1R (1)
Cysteine Protease (1)
CCR (1)
CETP (1)
c-Fms (1)
CFTR (1)
Chk (1)