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Compound Libraries Cytoskeletal Signaling Pathway Compound Library

Cytoskeletal Signaling Pathway Compound Library

Catalog No. L1310
  Library Compound List   Excel SDF

The cytoskeleton is a complex, dynamic network of interlinking protein filaments present in the cytoplasm of all cells, including bacteria and archaea. It extends from the cell nucleus to the cell membrane and is composed of similar proteins in the various organisms. In eukaryotes, it is composed of three main components, microfilaments, intermediate filaments and microtubules, and these are all capable of rapid growth or disassembly dependent on the cell's requirements. Microfilament functions include cytokinesis, amoeboid movement, cell motility, changes in cell shape, endocytosis and exocytosis, cell contractility, and mechanical stability. Microtubules provide structure and shape to eukaryotic cells and help localize membrane-enclosed organelles. Intermediate filaments have great tensile strength, and their main function is to enable cells to withstand the mechanical stress that occurs when cells are stretched.

The cytoskeleton is responsible for contraction, cell motility, movement of organelles and vesicles through the cytoplasm, cytokinesis, establishment of the intracellular organization of the cytoplasm, establishment of cell polarity, and many other functions that are essential for cellular homeostasis and survival. Many diseases have now been associated with abnormalities in cytoskeletal and nucleoskeletal proteins, including neurodegeneration such as Alzheimer's Disease (AD) with the accumulation of amyloid beta peptide, and the intracellular neurofibrillary tangles that composed of paired helical filaments of the microtubule-associated protein, tau; cancer (invasion) with cytoskeleton aberration like reduced microtubule polymerization, etc.

TargetMol’s Cytoskeletal Signaling Pathway Compound Library collects 343 compounds related to cytoskeletal regulation with targets on Microtubule/Tubulin, Kinesin, PKC, MAPK, etc. It can be used for research in cytoskeletal signaling pathway, cytoskeleton associated disease, and drug discovery.

Pack Size Price/USD
100 μL * 10 mM (in DMSO) 5710.00
250 μL * 10 mM (in DMSO) 9378.00
1 mg 9378.00
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Product Features

  • A unique collection of 343 cytoskeleton-related compounds, can be used for HTS and HCS;
  • Targets include Microtubule/Tubulin, Kinesin, PKC, MAPK, etc.;
  • Part of them are FDA-approved drugs;
  • Structural diversity with strong bioactivities and cell permeability;
  • Detailed compound information with structure, target, and biological activity description;
  • NMR and HPLC/LCMS validated to ensure high purity and quality.

Library Customization

Targetmol Compound Libraries can be highly customized! Learn More

Packaging And Storage

  • Powder or pre-dissolved DMSO solutions in 96/384 well plate with optional 2D barcode
  • Shipped with blue ice
Request Library Compound List (L1310)

Library Composition

Microtubule Associated (51)
p38 MAPK (47)
Bcr-Abl (40)
PKC (40)
Akt (39)
Wnt/beta-catenin (34)
HSP (31)
Integrin (24)
Src (17)
MAPK (16)
FAK (14)
c-Kit (12)
PKA (12)
PDGFR (11)
VEGFR (10)
Kinesin (8)
ERK (7)
EGFR (6)
CDK (6)
NF-κB (6)
FGFR (6)
PPAR (6)
Raf (5)
Aurora Kinase (5)
Casein Kinase (4)
Caspase (4)
c-Met/HGFR (4)
PYK2 (4)
ROCK (4)
PAK (4)
PARP (4)
PI3K (4)
Tyrosine Kinases (4)
TNF (3)
Topoisomerase (3)
Syk (3)
S6 Kinase (3)
Serine/threonin kinase (3)
SGK (3)
c-Fms (3)
ATPase (3)
FLT (3)
Gap Junction Protein (3)
IGF-1R (3)
mTOR (3)
Myosin (2)
NADPH (2)
LDL (2)
JNK (2)
MEK (2)
Hck (2)
HER (2)
HIF (2)
GPR (2)
Adrenergic Receptor (2)
BTK (2)
BCL (2)
DNA Alkylation (2)
c-RET (2)
Dynamin (2)
Carbonic Anhydrase (2)
Epigenetic Reader Domain (2)
Serine Protease (2)
Potassium Channel (2)
PDK (2)
STAT (2)
Trk receptor (2)
Tie-2 (2)
TACC (1)
TGF-beta/Smad (1)
Vitamin (1)
Wnk (1)
RAAS (1)
Ras (1)
Estrogen/progestogen Receptor (1)
E1/E2/E3 Enzyme (1)
Endogenous Metabolite (1)
Ephrin Receptor (1)
Cysteine Protease (1)
DHFR (1)
DNA (1)
DNA/RNA Synthesis (1)
Beta Amyloid (1)
CaMK (1)
AChR (1)
ACK (1)
ALK (1)
Aminopeptidase (1)
Apoptosis (1)
Arginase (1)
Aromatase (1)
ASK (1)
GSK-3 (1)
GST (1)
Glucokinase (1)
Gamma-secretase (1)
Histamine Receptor (1)
HIV Protease (1)
Hedgehog/Smoothened (1)
IL Receptor (1)
Mdm2 (1)
LRRK2 (1)
IκB/IKK (1)
JAK (1)
MLK (1)
MMP (1)
p53 (1)