Cytokine Inhibitor Library

Catalog No. L3600

Library Compound List Excel SDF

Cytokines are a broad and loose category of small proteins (~5–20 kDa) that are important in cell signaling, modulate the balance between humoral and cell-based immune responses, and are heavily involved in autoimmune and inflammatory diseases. Blocking cytokine signaling pathways by biologics has shown clinical effectiveness in these diseases.

Cytokines act through receptors and activate related signaling to modulate gene expression and cell functions. Cytokine receptors activate many signaling pathways: JAK-STAT, NF-kB, MAPK, PI3K, etc. A number of small molecular weight inhibitors targeting cytokine signaling have been identified as research progresses and some are approved to be marketed. Cytokines Inhibitors Library from TargetMol, containing 182 compounds targeting cytokine signaling, can be used for high throughput and high content screening for drug discovery.

Pack Size	Price/USD
100 μL * 10 mM (in DMSO)	4282.00
250 μL * 10 mM (in DMSO)	6060.00
1 mg	6060.00

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Product Description

A unique collection of 182 compounds targeting cytokine signaling for high throughput screening and high content screening for drug discovery;
Bioactivity and safety confirmed by pre-clinical research and clinical trials, and most of them are approved to be marketed;
Targets cover various cytokines including IL, CSF, IFN, TNF, TGF-beta family, growth factors, chemokine family, etc;
Detailed compound information with structure, target, activity, IC50 value, and biological activity description;
Structurally diverse, medicinally active, and cell permeable;
NMR and HPLC validated to ensure high purity and quality;

Library Customization

Targetmol Compound Libraries can be highly customized! Learn More

Packaging and Storage

Powder or pre-dissolved DMSO solutions in 96 well plate with optional 2D barcode
Shipped with blue ice.

Supporting Files

Library Handling Instructions (927 KB) Targetmol Library Catalog (13.2 MB) Request for Library Compostion in Excel and SDF files

Library Composition

VEGFR (38)

EGFR (36)

PDGFR (27)

TNF (24)

ALK (24)

c-Kit (21)

FGFR (19)

IL Receptor (17)

FLT (16)

TGF-beta/Smad (14)

Src (13)

Bcr-Abl (9)

JAK (7)

IGF-1R (7)

NF-κB (6)

Raf (6)

HER (5)

c-Met/HGFR (5)

CSF-1R (5)

CXCR (5)

CCR (4)

PDE (4)

Tyrosine Kinases (3)

COX (3)

c-RET (3)

c-Fms (2)

Annexin A (2)

5-HT Receptor (2)

Histamine Receptor (2)

GR (2)

Hck (2)

Ephrin Receptor (2)

TAM Receptor (2)

Trk receptor (2)

NOS (2)

PKA (2)

NOD (2)

mTOR (2)

MEK (2)

MMP (1)

MRP (1)

Norepinephrine (1)

p38 MAPK (1)

Reductase (1)

ROS (1)

S6 Kinase (1)

Serine Protease (1)

Serine/threonin kinase (1)

Sigma receptor (1)

Sodium Channel (1)

PKC (1)

Potassium Channel (1)

STAT (1)

Phospholipase (1)

PI3K (1)

Tyrosinase (1)

Tie-2 (1)

ERK (1)

Estrogen/progestogen Receptor (1)

FAAH (1)

FAK (1)

HDAC (1)

IκB/IKK (1)

JNK (1)

LTR (1)

lysosomal autophagy (1)

ACK (1)

Adenosine Receptor (1)

Adrenergic Receptor (1)

Aurora Kinase (1)

CDK (1)

CFTR (1)

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2-Methoxyestradiol 10 mM * 1 mL in DMSO x 1	980 $
2-Methoxyestradiol 10 mg x 1	980 $