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Compound Libraries CNS-Penetrant Compound Library

CNS-Penetrant Compound Library

Catalog No. L5900
  Library Compound List   Excel SDF

The blood–brain barrier (BBB) is a highly selective semipermeable border that separates the circulating blood from the brain and extracellular fluid in the central nervous system (CNS). In its neuroprotective role, the blood–brain barrier functions to hinder the delivery of many potentially important diagnostic and therapeutic agents to the brain. Overcoming the difficulty of delivering therapeutic agents to specific regions of the brain presents a major challenge to treatment of most brain disorders. Choosing the compounds that could penetrate BBB into the compound library targeting CNS is critical for CNS drug discovery. Based on the scientific literature, TargetMol collects 516 out of 5000 compounds as CNS-Penetrant Compound Library, which can be used for CNS-Penetrant related research and drug screening for CNS diseases.

Pack Size Price/USD
100 μL * 10 mM (in DMSO) 8588.00
250 μL * 10 mM (in DMSO) 14110.00
1 mg 14110.00
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Product Description

  • A unique collection of 516 CNS-Penetrant compounds for high throughput screening (HTS) and high content screening (HCS);
  • Targets include Kinases, GPCR, and ion channels, etc.;
  • Effective tool for drug screening in brain disorders, such as brain tumor, mental disorders, and neurodegenerative diseases, etc.;
  • Detailed compound information with structure, target, activity, IC50 value, and biological activity description;
  • Structurally diverse, medicinally active, and cell permeable and CNS penetrant;
  • NMR and HPLC/LCMS validated to ensure high purity and quality;

Library Customization

Targetmol Compound Libraries can be highly customized! Learn More

Packaging And Storage

  • Powder or pre-dissolved DMSO solutions in 96/384 well plate with optional 2D barcode
  • Shipped with blue ice
Request Library Compound List (L5900)

Library Composition

5-HT Receptor (50)
Dopamine Receptor (39)
AChR (35)
Adrenergic Receptor (25)
COX (24)
GABA Receptor (19)
Sodium Channel (16)
EGFR (15)
Histamine Receptor (15)
DNA/RNA Synthesis (12)
Antibiotic (12)
c-Kit (11)
HDAC (11)
Norepinephrine (11)
VEGFR (11)
CDK (10)
Calcium Channel (10)
Estrogen/progestogen Receptor (9)
PDGFR (9)
PI3K (9)
HIV Protease (9)
FLT (8)
GluR (8)
Bcr-Abl (8)
Glucocorticoid Receptor (7)
Dehydrogenase (7)
Potassium Channel (7)
NMDAR (7)
Topoisomerase (7)
Raf (7)
TNF (6)
Src (6)
mTOR (6)
NF-κB (6)
PDE (6)
Reverse Transcriptase (6)
Microtubule Associated (6)
GR (6)
Antifection (6)
Antibacterial (6)
Autophagy (5)
CSF-1R (5)
MAO (5)
MRP (5)
S1P Receptor (5)
TRP/TRPV Channel (4)
MEK (4)
MMP (4)
DNA Alkylation (4)
Carbonic Anhydrase (4)
ATM/ATR (3)
ABC (3)
ALK (3)
FGFR (3)
Epigenetic Reader Domain (3)
HMG-CoA Reductase (3)
LRRK2 (3)
NOS (3)
p38 MAPK (3)
Parasite (3)
PARP (3)
PPAR (3)
Prostaglandin Receptor (3)
Tyrosine Kinases (3)
Serotonin Transporter (3)
Retinoid Receptor (3)
Transferase (3)
TGF-beta/Smad (2)
STAT (2)
Sirtuin (2)
Vasopressin Receptor (2)
P-gp (2)
ROCK (2)
ROR (2)
ROS (2)
RAAS (2)
P450 (2)
Opioid Receptor (2)
HSP (2)
MAPK (2)
IL Receptor (2)
ERK (2)
Endogenous Metabolite (2)
FAAH (2)
GPR (2)
Decarboxylase (2)
DHFR (2)
DNA-PK (2)
c-Fms (2)
AMPK (2)
Annexin A (2)
Antifungal (2)
advanced glycation end products (2)
Adenosine Receptor (2)
Akt (2)
BCL (2)
CAT (2)
CaMK (2)
Cannabinoid Receptor (1)
Beta Amyloid (1)
BTK (1)
CCR (1)
Caspase (1)
BACE (1)
ATP Citrate Lyase (1)
Aurora Kinase (1)
Antifolate (1)
AhR (1)
ACAT (1)
Acyltransferase (1)
Antiviral (1)
Apoptosis (1)
Aromatase (1)
Amino Acids and Derivatives (1)
CFTR (1)
Chk (1)
Chloride channel (1)
Cysteine Protease (1)
c-Met/HGFR (1)
E1/E2/E3 Enzyme (1)
GlyT (1)
Free radical scavengers (1)
Fatty Acid Synthase (1)
Ferroptosis (1)
Influenza Virus (1)
Integrin (1)
Isocitrate Dehydrogenase (IDH) (1)
IκB/IKK (1)
JAK (1)
JNK (1)
LDL (1)
Lipase (1)
Lipid (1)
Lipoxygenase (1)
Liver X Receptor (1)
GSK-3 (1)
GST (1)
HCV Protease (1)
Hedgehog/Smoothened (1)
HIF (1)
HIF/HIF Prolyl-Hydroxylase (1)
Mdm2 (1)
Melatonin Receptor (1)
Monoamine Transporter (1)
MPO (1)
Mitophagy (1)
MLK (1)
Hydrogenase (1)
Hydroxylase (1)
IGF-1R (1)
lysosomal autophagy (1)
Histone Acetyltransferase (1)
Histone Demethylase (1)
OX Receptor (1)
P2 Receptor (1)
PD-1/PD-L1 (1)
Nucleoside Antimetabolite/Analog (1)
NOD (1)
MT Receptor (1)
NADPH (1)
Neurokinin receptor (1)
PKC (1)
Phosphatase (1)
Phospholipase (1)
PDK (1)
Proteasome (1)
Tyrosinase (1)
Vitamin (1)
Wnt/beta-catenin (1)
SGK (1)
Sigma receptor (1)
S6 Kinase (1)
Ras (1)
Reductase (1)
Syk (1)
TACC (1)
Telomerase (1)
Trk receptor (1)