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Compound Libraries Neuronal Signaling Compound Library

Neuronal Signaling Compound Library

Catalog No. L2600
  Library Compound List   Excel SDF

Communication between and within neurons is critical for all functions of the nervous system, from development to aging, through health and disease. The last decade has seen huge advances in our knowledge of the molecular, cellular and systematic signaling pathways within the nervous system. There have been significant breakthroughs in studies on the signaling pathways that underlie neurogenesis, addiction and autism spectrum disorders, as well as the pathophysiology and treatment of mood disorders. G protein-coupled receptors(GPCRs), including 5-HT receptors, histamine receptors, opioid receptors, are the largest family of signaling proteins to neuronal signaling. Changes in the GPCRs functioning can cause diseases many Neurological Disorders; Notch signaling is essential for proliferation, survival, self-renew, and differentiation of neural stem cells (NSCs). Notch signaling in neurons, glia and NSCs may be involved in pathological changes that occur in disorders such as stroke, Alzheimer’s disease and CNS tumors. Therefore, the potential of agents that target notch signaling could be used as therapeutic interventions for several different CNS disorders.

The Neuronal Signaling Compound Library by TargetMol, containing 1404 compounds targeting CNS signaling, can be used for high throughput screening and high content screening for new drugs in neurological disorders.

Pack Size Price/USD
100 μL * 10 mM (in DMSO) 13575.00
250 μL * 10 mM (in DMSO) 22470.00
1 mg 22470.00
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Product Description

  • A unique collection of 1404 compounds targeting CNS signaling for high throughput screening (HTS) and high content screening (HCS) for new drugs;
  • Bioactivity and safety confirmed by pre-clinical research and clinical trials;
  • Targets include 5-HT receptor, AChR, Histamine receptor, dopamine receptor, Opioid receptor, etc;
  • Detailed compound information with structure, target, activity, IC50 value, and biological activity description;
  • Structurally diverse, medicinally active, and cell permeable;
  • NMR and HPLC validated to ensure high purity and quality;

Library Customization

Targetmol Compound Libraries can be highly customized! Learn More

Packaging And Storage

  • Powder or pre-dissolved DMSO solutions in 96/384 well plate with optional 2D barcode
  • Shipped with blue ice
Request Library Compound List (L2600)

Library Composition

AChR (138)
5-HT Receptor (131)
COX (107)
Dopamine Receptor (82)
Histamine Receptor (72)
Adrenergic Receptor (56)
GABA Receptor (36)
GluR (33)
Sodium Channel (33)
Norepinephrine (24)
MAO (20)
NMDAR (17)
Potassium Channel (17)
Calcium Channel (15)
Opioid Receptor (14)
P2 Receptor (12)
Gamma-secretase (12)
CaMK (11)
PDE (10)
TRP/TRPV Channel (8)
Beta Amyloid (8)
EGFR (8)
Dehydrogenase (7)
DNA/RNA Synthesis (7)
Cannabinoid Receptor (7)
Bcr-Abl (7)
Adenosine Receptor (7)
Amino Acids and Derivatives (7)
P450 (7)
NF-κB (7)
Glucocorticoid Receptor (6)
MRP (6)
Lipoxygenase (6)
OX Receptor (6)
PPAR (6)
Raf (6)
Phospholipase (6)
c-Kit (6)
FAAH (6)
GSK-3 (6)
HDAC (6)
VEGFR (6)
Estrogen/progestogen Receptor (5)
Androgen Receptor (5)
BACE (5)
TNF (5)
Transferase (5)
Reverse Transcriptase (4)
MPO (4)
NADPH (4)
P-gp (4)
Neurokinin receptor (3)
mTOR (3)
MMP (3)
Src (3)
Tyrosine Kinases (3)
Reductase (3)
p38 MAPK (3)
PDGFR (3)
BCL (3)
Carbonic Anhydrase (3)
Chloride channel (3)
Antibacterial (3)
ABC (3)
GR (3)
FLT (2)
GluCls (2)
ERK (2)
Endogenous Metabolite (2)
DNA Alkylation (2)
ACK (2)
advanced glycation end products (2)
BTK (2)
Autophagy (2)
Antioxidant (2)
ATP Citrate Lyase (2)
ROS (2)
Sigma receptor (2)
Sirtuin (2)
Monocarboxylate transporter (2)
MT Receptor (2)
NOS (2)
lysosomal autophagy (2)
HMG-CoA Reductase (2)
Hydroxylase (2)
Melatonin Receptor (2)
IL Receptor (2)
Integrin (2)
IκB/IKK (2)
LDL (2)
Vitamin (2)
Lipase (1)
Histone Demethylase (1)
Histone Methyltransferase (1)
HIV Protease (1)
Microtubule Associated (1)
MAPK (1)
IAP (1)
NOD (1)
Monoamine Transporter (1)
Rho (1)
ROR (1)
Syk (1)
Telomerase (1)
TGF-beta/Smad (1)
Thrombin (1)
UGT (1)
Vasopressin Receptor (1)
Tyrosinase (1)
transporter (1)
Trk receptor (1)
PAFR (1)
Parasite (1)
Retinoid Receptor (1)
Prostaglandin Receptor (1)
PI3K (1)
PKA (1)
Platelet aggregation (1)
Aurora Kinase (1)
Apoptosis (1)
Apoptosis inducer (1)
Beta-Secretase (1)
CAT (1)
CCR (1)
c-Fms (1)
AhR (1)
ALK (1)
Acyltransferase (1)
ACAT (1)
Antibiotic (1)
Antifungal (1)
Annexin A (1)
AMPK (1)
Adiponectin receptor (1)
DNA Methyltransferase (1)
DHFR (1)
Discoidin Domain Receptor (DDR) (1)
Cysteine Protease (1)
Decarboxylase (1)
Epigenetic Reader Domain (1)
DYRK (1)
FAK (1)
Ferroptosis (1)
Gap Junction Protein (1)
GlyT (1)
GNRH Receptor (1)
GPR (1)
GRK (1)
GST (1)
HCV Protease (1)
Hedgehog/Smoothened (1)
HER (1)
HIF (1)