Approved Drug Library

Catalog No. L1000

Library Compound List Excel SDF

Traditional de novo drug discovery and development involves an HTS campaign for de novo candidate hits and requires highly specialized screening facilities and compound libraries containing several million compounds. It is a time consuming and expensive process. As the regulation for drug safety and efficacy is increasingly getting complex, the cost of developing new drugs is keeping skyrocket. Drug repositioning, also known as old drugs for new uses, is an effective strategy to find new indications for existing drugs and has recently drawn attention and has led to several blockbuster drugs because of its high efficiency and low-cost. High-content screens, new biomarkers, noninvasive imaging techniques, and advanced in bioinformatics have created new opportunities for pursuing novel indications for approved compounds.

Approved drugs all have known and well-characterized bioactivities, safety and bioavailability – properties which could dramatically accelerate drug development and optimization. Hits from this set will provide a significant head start in any drug optimization program.

In addition, a growing number of compounds have been identified from this library that can functionally replace reprogramming transcription factors, enhance efficiency of iPSC generation and accelerate the reprogramming process by single use or a combination of several molecules.

We put the compounds that should be provided in the form of dry powder together to form Part B in order to ensure the best using effect of the compound library and increase the probability of successful screening as much as possible.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.

Pack Size
1 mg
30 μL * 10 mM (in DMSO)
50 μL * 10 mM (in DMSO)
100 μL * 10 mM (in DMSO)
250 μL * 10 mM (in DMSO)

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please contact our compound library specialist for a customized compound library at inquiry@targetmol.com

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Product Description

A unique collection of 2863 approved drugs for high throughput screening (HTS) and high content screening (HCS);
All compounds collected in this library are drugs approved by Food and Drug Administration (FDA), the European Medicine Agency (EMA), or National Medical Products Administration (NMPA), etc;
An effective tool for discovering new with old drugs and new drug target identification;
Covers various research areas, such as Cancer, Cardiovascular disease, GPCR/G protein, Neuroscience, Membrane Transporter/Ion Channel, Microbiology & Virology, Immunology/Inflammation, Tyrosine Kinase/Adaptors, etc.
More detailed compound information with structure, target, activity, IC50 value, and brief introduction;
Structurally diverse, medicinally active, and cell permeable;
NMR and HPLC validated to ensure high purity and quality;

Library Customization

Targetmol Compound Libraries can be highly customized! Learn More

Packaging And Storage

Powder or pre-dissolved DMSO solutions in 96/384 well plate with optional 2D barcode
Shipped with blue ice

Supporting Files

Library Handling Instructions (635 KB) Targetmol Library Catalog (13.2 MB) Request for Library Compostion in Excel and SDF files

Library Composition

Antibacterial (412)

Antibacterial (411)

Antibiotic (387)

Antibiotic (385)

Autophagy (346)

Autophagy (344)

Endogenous Metabolite (261)

Endogenous Metabolite (260)

Apoptosis (255)

Apoptosis (253)

Adrenergic Receptor (165)

5-HT Receptor (164)

Adrenergic Receptor (164)

5-HT Receptor (161)

AChR (141)

AChR (138)

COX (119)

Dopamine Receptor (110)

Histamine Receptor (102)

Parasite (92)

Parasite (91)

Antifungal (86)

DNA/RNA Synthesis (85)

HIV Protease (84)

Sodium Channel (83)

Potassium Channel (77)

Potassium Channel (76)

Calcium Channel (75)

Glucocorticoid Receptor (55)

Topoisomerase (55)

Glucocorticoid Receptor (55)

Topoisomerase (55)

Estrogen/progestogen Receptor (48)

Ferroptosis (48)

Estrogen/progestogen Receptor (47)

Influenza Virus (45)

PDE (45)

PDE (44)

Influenza Virus (44)

P450 (43)

SARS-CoV (41)

Reactive Oxygen Species (38)

RAAS (38)

Reactive Oxygen Species (38)

NF-κB (37)

GABA Receptor (37)

NF-κB (37)

GABA Receptor (37)

EGFR (34)

ribosome (33)

Mitophagy (33)

Dehydrogenase (32)

VEGFR (31)

HCV Protease (31)

AChE (30)

Nucleoside Antimetabolite/Analog (30)

HCV Protease (30)

c-Kit (30)

Nucleoside Antimetabolite/Analog (30)

AChE (30)

Serotonin Transporter (29)

PPAR (29)

Serotonin Transporter (29)

PPAR (29)

Prostaglandin Receptor (28)

PDGFR (28)

Prostaglandin Receptor (28)

HSV (26)

Reverse Transcriptase (26)

Microtubule Associated (25)

Estrogen Receptor/ERR (25)

Norepinephrine (24)

Proteasome (24)

Estrogen Receptor/ERR (24)

Norepinephrine (24)

Proteasome (24)

Opioid Receptor (23)

Antifection (22)

Progesterone Receptor (22)

ATPase (21)

MAO (21)

Proton pump (21)

HBV (21)

DNA Alkylator/Crosslinker (21)

Proton pump (21)

HBV (21)

DNA Alkylator/Crosslinker (21)

ATPase (21)

MAO (21)

Opioid Receptor (21)

iGluR (20)

Androgen Receptor (19)

Virus Protease (19)

Carbonic Anhydrase (19)

Virus Protease (19)

Carbonic Anhydrase (19)

Androgen Receptor (19)

HDAC (19)

Thrombin (18)

FLT (17)

TNF (16)

c-Met/HGFR (16)

TNF (16)

Monoamine Oxidase (16)

TRP/TRPV Channel (16)

c-Met/HGFR (16)

Monoamine Oxidase (16)

TRP/TRPV Channel (16)

FGFR (16)

ROS (15)

Adenosine Receptor (15)

DPP-4 (14)

Bcr-Abl (14)

GNRH Receptor (14)

Bcr-Abl (14)

MRP (14)

JAK (14)

Transferase (14)

MRP (14)

GNRH Receptor (14)

DPP-4 (14)

Transferase (14)

JAK (14)

NMDAR (13)

Phosphatase (13)

Tyrosine Kinases (13)

NMDAR (13)

Src (13)

Antifolate (13)

Tyrosine Kinases (13)

Src (13)

Phosphatase (13)

Drug Metabolite (12)

Retinoid Receptor (12)

Drug Metabolite (12)

Raf (12)

Amino Acids and Derivatives (12)

Retinoid Receptor (12)

PKC (11)

Thyroid hormone receptor(THR) (11)

DNA gyrase (11)

Phospholipase (11)

GluR (11)

Mitochondrial Metabolism (11)

P-gp (11)

DNA gyrase (11)

Phospholipase (11)

P-gp (11)

Thyroid hormone receptor(THR) (11)

IL Receptor (11)

CDK (11)

PKC (11)

DHFR (11)

GluR (11)

DHFR (11)

Mitochondrial Metabolism (11)

CDK (11)

HMG-CoA Reductase (11)

IL Receptor (11)

HMG-CoA Reductase (11)

MMP (10)

c-RET (10)

CaMK (10)

MMP (10)

CaMK (10)

Lipoxygenase (10)

c-RET (10)

ALK (10)

Factor Xa (10)

Lipoxygenase (10)

PARP (10)

SGLT (9)

DNA Alkylation (9)

AMPK (9)

DNA Alkylation (9)

PARP (9)

NO Synthase (9)

AMPK (9)

NO Synthase (9)

Tyrosinase (8)

mTOR (8)

ABC (8)

Antiviral (8)

ABC (8)

CAT (8)

Chloride channel (8)

HIF/HIF Prolyl-Hydroxylase (8)

Interleukin (8)

CAT (8)

P2Y Receptor (8)

PI3K (8)

Antiviral (8)

HIF/HIF Prolyl-Hydroxylase (8)

HER (8)

PI3K (8)

Interleukin (8)

P2Y Receptor (8)

Chloride channel (8)

HER (8)

Vasopressin Receptor (7)

MEK (7)

Glucagon Receptor (7)

STAT (7)

Glucagon Receptor (7)

Antioxidant (7)

Guanylate cyclase (7)

Neurokinin receptor (7)

Vasopressin Receptor (7)

Serine Protease (7)

STAT (7)

Serine Protease (7)

Monoamine Transporter (7)

CFTR (7)

GPR (7)

CFTR (7)

Beta Amyloid (7)

GPR (7)

Monoamine Transporter (7)

Guanylate cyclase (7)

Neurokinin receptor (7)

Beta Amyloid (7)

MEK (7)

Nrf2 (6)

Hedgehog/Smoothened (6)

Glutathione Peroxidase (6)

DNA (6)

S1P Receptor (6)

ERK (6)

Trk receptor (6)

BTK (6)

DNA (6)

Hedgehog/Smoothened (6)

ERK (6)

BCL (6)

Trk receptor (6)

Sigma receptor (6)

NADPH (6)

BCL (6)

BTK (6)

Reductase (6)

DNA Methyltransferase (6)

Glutathione Peroxidase (6)

S1P Receptor (6)

CaSR (6)

NADPH (6)

Aromatase (6)

Reductase (6)

CaSR (6)

Nrf2 (6)

TAM Receptor (6)

Aromatase (6)

TAM Receptor (6)

Cysteine Protease (5)

Caspase (5)

Akt (5)

Leukotriene Receptor (5)

Cell wall (5)

Endothelin Receptor (5)

Integrin (5)

FXR (5)

LPL Receptor (5)

DNA Methyltransferase (5)

Integrin (5)

Wnt/beta-catenin (5)

Cysteine Protease (5)

TLR (5)

Cell wall (5)

Wnt/beta-catenin (5)

Endothelin Receptor (5)

Oxytocin Receptor (5)

PKA (5)

LPL Receptor (5)

ROCK (5)

PKA (5)

ROCK (5)

Fatty Acid Synthase (5)

Sigma receptor (5)

Anti-infection (5)

HSP (5)

TLR (5)

Hydroxylase (5)

Xanthine Oxidase (5)

FXR (5)

Akt (5)

Hydroxylase (5)

Histone Methyltransferase (5)

Anti-infection (5)

Histone Methyltransferase (5)

Caspase (5)

Oxytocin Receptor (5)

Leukotriene Receptor (5)

Fatty Acid Synthase (5)

Xanthine Oxidase (5)

NOS (4)

P2X Receptor (4)

CXCR (4)

Annexin A (4)

IκB/IKK (4)

NOS (4)

ROS Kinase (4)

Histone Demethylase (4)

MT Receptor (4)

p38 MAPK (4)

Decarboxylase (4)

Neprilysin (4)

Smo (4)

Decarboxylase (4)

Ras (4)

PGE Synthase (4)

Histone Demethylase (4)

GSK-3 (4)

NOD (4)

HSP (4)

P2X Receptor (4)

p38 MAPK (4)

GSK-3 (4)

UGT (4)

Melatonin Receptor (4)

Smo (4)

LTR (4)

CXCR (4)

GPCR19 (4)

Neprilysin (4)

ROS Kinase (4)

Lipid (4)

Melatonin Receptor (4)

PGE Synthase (4)

Lipid (4)

Ras (4)

LTR (4)

GPCR19 (4)

NOD (4)

HIF (3)

Complement System (3)

cholecystokinin (3)

IGF-1R (3)

CGRP Receptor (3)

Aryl Hydrocarbon Receptor (3)

Adenosine deaminase (3)

AhR (3)

PAK (3)

Aminopeptidase (3)

AhR (3)

Arginase (3)

CGRP Receptor (3)

CCR (3)

Melanocortin Receptor (3)

c-Fms (3)

IGF-1R (3)

Gap Junction Protein (3)

c-Fms (3)

Cannabinoid Receptor (3)

Imidazoline Receptor (3)

CCR (3)

Aminopeptidase (3)

Serine/threonin kinase (3)

GST (3)

Arginase (3)

Glucosidase (3)

Serine/threonin kinase (3)

HIF (3)

PAK (3)

GST (3)

Aryl Hydrocarbon Receptor (3)

TGF-beta/Smad (3)

Glutathione reductase (3)

Glucosidase (3)

MT Receptor (3)

Syk (3)

TGF-beta/Smad (3)

Gap Junction Protein (3)

Free radical scavengers (3)

Complement System (3)

Glutathione reductase (3)

FAK (3)

NOD-like Receptor (NLR) (3)

Syk (3)

Cannabinoid Receptor (3)

NOD-like Receptor (NLR) (3)

Melanocortin Receptor (3)

Free radical scavengers (3)

Imidazoline Receptor (3)

FAK (3)

cholecystokinin (3)

Adenosine deaminase (3)

Monocarboxylate transporter (2)

GHSR (2)

TOPK (2)

Gamma-secretase (2)

Acyltransferase (2)

CETP (2)

YAP (2)

Isocitrate Dehydrogenase (IDH) (2)

Integrase (2)

Ephrin Receptor (2)

GluCls (2)

GHSR (2)

Beta-Secretase (2)

Thrombopoietin Receptor (2)

Beta-Secretase (2)

IRE1 (2)

OAT (2)

MAPK (2)

Hexokinase (2)

PLK (2)

IRE1 (2)

Protease-activated Receptor (2)

LDL (2)

Somatostatin (2)

Rho (2)

ROR (2)

RSV (2)

Isocitrate Dehydrogenase (IDH) (2)

Sirtuin (2)

GluCls (2)

Na-K-Cl cotransporter (2)

GlyT (2)

YAP (2)

Acyltransferase (2)

LDL (2)

Thrombopoietin Receptor (2)

Rho (2)

Somatostatin (2)

Protease-activated Receptor (2)

PKM (2)

Ephrin Receptor (2)

GlyT (2)

Gamma-secretase (2)

PLK (2)

Monocarboxylate transporter (2)

MAPK (2)

Integrase (2)

ROR (2)

Na-K-Cl cotransporter (2)

Sirtuin (2)

Hexokinase (2)

CRM1 (2)

RSV (2)

Phosphorylase (1)

advanced glycation end products (1)

BACE (1)

FAAH (1)

VDA (1)

NPC1L1 (1)

ACK (1)

OX Receptor (1)

CRISPR/Cas9 (1)

Histone Acetyltransferase (1)

Pyroptosis (1)

DUB (1)

p53 (1)

PAD (1)

PAFR (1)

Dynamin (1)

Taste receptor (1)

RAR/RXR (1)

Indoleamine 2,3-Dioxygenase (IDO) (1)

NADPH-oxidase (1)

Mdm2 (1)

CSF-1R (1)

Lipase (1)

Liver X Receptor (1)

Lipase (1)

IAP (1)

advanced glycation end products (1)

CRISPR/Cas9 (1)

Histone Acetyltransferase (1)

Phosphorylase (1)

Na+/Ca2+ Exchanger (1)

Chk (1)

Hydrogenase (1)

Na+/Ca2+ Exchanger (1)

IFNAR (1)

MTH1 (1)

Dynamin (1)

Angiotensin-converting Enzyme (ACE) (1)

JNK (1)

PD-1/PD-L1 (1)

GRK (1)

PKM (1)

Epoxide Hydrolase (1)