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Compound Libraries Approved Drug Library

Approved Drug Library

Catalog No. L1000
  Library Compound List   Excel SDF

Traditional de novo drug discovery and development involves an HTS campaign for de novo candidate hits and requires highly specialized screening facilities and compound libraries containing several million compounds. It is a time consuming and expensive process. As the regulation for drug safety and efficacy is increasingly getting complex, the cost of developing new drugs is keeping skyrocket. Drug repositioning, also known as old drugs for new uses, is an effective strategy to find new indications for existing drugs and has recently drawn attention and has led to several blockbuster drugs because of its high efficiency and low-cost. High-content screens, new biomarkers, noninvasive imaging techniques, and advanced in bioinformatics have created new opportunities for pursuing novel indications for approved compounds.

Approved drugs all have known and well-characterized bioactivities, safety and bioavailability – properties which could dramatically accelerate drug development and optimization. Hits from this set will provide a significant head start in any drug optimization program.

In addition, a growing number of compounds have been identified from this library that can functionally replace reprogramming transcription factors, enhance efficiency of iPSC generation and accelerate the reprogramming process by single use or a combination of several molecules.

We provide the peptides and other drug molecules with low solution stability in the form of dry powder (set as Part B) in order to ensure the best using effect of the compound library and increase the probability of successful screening as much as possible.

Pack Size Price/USD
100 μL * 10 mM (in DMSO) 11780.00
250 μL * 10 mM (in DMSO) 23424.00
1 mg 23424.00
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Product Description

  • A unique collection of 2356 approved drugs for high throughput screening (HTS) and high content screening (HCS);
  • All compounds collected in this library are drugs approved by Food and Drug Administration (FDA), the European Medicine Agency (EMA), or China Food and Drug Administration (CFDA), etc;
  • An effective tool for discovering new with old drugs and new drug target identification;
  • Covers various research areas, such as Cancer, Cardiovascular disease, GPCR/G protein, Neuroscience, Membrane Transporter/Ion Channel, Microbiology & Virology, Immunology/Inflammation, Tyrosine Kinase/Adaptors, etc.
  • More detailed compound information with structure, target, activity, IC50 value, and brief introduction;
  • Structurally diverse, medicinally active, and cell permeable;
  • NMR and HPLC validated to ensure high purity and quality;

Library Customization

Targetmol Compound Libraries can be highly customized! Learn More

Packaging And Storage

  • Powder or pre-dissolved DMSO solutions in 96/384 well plate with optional 2D barcode
  • Shipped with blue ice
Request Library Compound List (L1000)

Library Composition

Adrenergic Receptor (134)
AChR (131)
5-HT Receptor (124)
Antibiotic (109)
COX (96)
Antibacterial (91)
Dopamine Receptor (84)
Histamine Receptor (68)
Sodium Channel (63)
DNA/RNA Synthesis (62)
Estrogen/progestogen Receptor (53)
Potassium Channel (53)
Calcium Channel (51)
Glucocorticoid Receptor (48)
Topoisomerase (44)
PDE (39)
GR (38)
Autophagy (38)
Vitamin (35)
RAAS (31)
HIV Protease (31)
GABA Receptor (29)
EGFR (28)
ribosome (28)
VEGFR (27)
Endogenous Metabolite (27)
Dehydrogenase (26)
Antifungal (26)
PPAR (25)
P450 (24)
Antifection (23)
c-Kit (22)
HCV Protease (22)
Norepinephrine (22)
Microtubule Associated (22)
PDGFR (21)
MAO (20)
Carbonic Anhydrase (18)
Androgen Receptor (17)
HDAC (17)
Bcr-Abl (16)
Opioid Receptor (16)
NF-κB (16)
MRP (15)
Prostaglandin Receptor (15)
Reverse Transcriptase (15)
ATPase (15)
Thrombin (14)
TNF (13)
DNA Alkylation (13)
FLT (12)
GluR (12)
Tyrosine Kinases (12)
NMDAR (12)
Raf (11)
Src (11)
ROS (11)
FGFR (11)
DPP-4 (11)
JAK (11)
IL Receptor (11)
Amino Acids and Derivatives (11)
DHFR (10)
DNA gyrase (10)
Thyroid hormone receptor(THR) (10)
Proton pump (10)
Retinoid Receptor (10)
PKC (10)
Parasite (9)
NADPH (9)
Lipoxygenase (9)
CDK (9)
CAT (8)
CaMK (8)
c-RET (8)
ALK (8)
Influenza Virus (8)
HMG-CoA Reductase (8)
Factor Xa (8)
MMP (8)
TRP/TRPV Channel (8)
Tyrosinase (8)
Transferase (7)
SGLT (7)
Phospholipase (7)
P2 Receptor (7)
Proteasome (7)
HBV (7)
ABC (7)
Antiviral (7)
Aromatase (7)
c-Met/HGFR (7)
Chloride channel (6)
CFTR (6)
HER (6)
GNRH Receptor (6)
PARP (6)
STAT (6)
Serine Protease (5)
Vasopressin Receptor (5)
PI3K (5)
PKA (5)
Reductase (5)
MEK (5)
MPO (5)
NOS (5)
HIF (5)
HSV (5)
GPR (5)
Integrin (5)
Hydroxylase (5)
AMPK (5)
Annexin A (5)
Antioxidant (5)
Adenosine Receptor (5)
Cysteine Protease (4)
BCL (4)
BTK (4)
IκB/IKK (4)
Hedgehog/Smoothened (4)
GSK-3 (4)
Fatty Acid Synthase (4)
DNA Methyltransferase (4)
Lipid (4)
mTOR (4)
Monoamine Transporter (4)
TAM Receptor (4)
UGT (4)
Trk receptor (3)
Syk (3)
TLR (3)
S1P Receptor (3)
ROCK (3)
Sigma receptor (3)
Serotonin Transporter (3)
MT Receptor (3)
Nucleoside Antimetabolite/Analog (3)
Neurokinin receptor (3)
Na-K-Cl cotransporter (3)
NOD (3)
p38 MAPK (3)
CXCR (3)
Endothelin Receptor (3)
GST (3)
GPCR19 (3)
Free radical scavengers (3)
FXR (3)
HSP (3)
LTR (3)
LDL (3)
Cell wall (3)
CaSR (3)
Decarboxylase (3)
AhR (3)
Arginase (3)
ATP Citrate Lyase (2)
Akt (2)
Aminopeptidase (2)
ACAT (2)
AChE (2)
DNA (2)
c-Fms (2)
Chk (2)
Cannabinoid Receptor (2)
Caspase (2)
CCR (2)
MAPK (2)
Integrase (2)
Histone Methyltransferase (2)
Gap Junction Protein (2)
GluCls (2)
Glucokinase (2)
Glutathione reductase (2)
GlyT (2)
Guanylate cyclase (2)
Ephrin Receptor (2)
Ferroptosis (2)
P-gp (2)
Phosphatase (2)
PKM (2)
PLK (2)
Protease-activated Receptor (2)
Neprilysin (2)
Monocarboxylate transporter (2)
Melatonin Receptor (2)
Monoamine Oxidase (2)
Mitochondrial Metabolism (2)
SARS-CoV (2)
Sirtuin (2)
ROR (2)
Rho (2)
Serine/threonin kinase (2)
TGF-beta/Smad (2)
Wnt/beta-catenin (2)
VDA (1)
Thrombopoietin Receptor (1)
Telomerase (1)
S6 Kinase (1)
Smo (1)
Somatostatin (1)
Mitophagy (1)
Melanocortin Receptor (1)
MTH1 (1)
N-Acetylglucosaminyltransferase (1)
NADPH-oxidase (1)
NOD-like Receptor (NLR) (1)
NKCC (1)
OAT (1)
OX Receptor (1)
Oxytocin Receptor (1)
NPC1L1 (1)
Nrf2 (1)
Progesterone Receptor (1)
Platelet aggregation (1)
RAR/RXR (1)
Ras (1)
Phosphorylase (1)
p53 (1)
PAFR (1)
PDK (1)
PED (1)
PGE Synthase (1)
FAK (1)
Epigenetic Reader Domain (1)
ERK (1)
Estrogen Receptor/ERR (1)
DUB (1)
Electron transport (1)
GRK (1)
GHSR (1)
Histone Demethylase (1)
Hydrogenase (1)
Hck (1)
HIF/HIF Prolyl-Hydroxylase (1)
Hexokinase (1)
IAP (1)
IGF-1R (1)
iGluR (1)
Mdm2 (1)
lysosomal autophagy (1)
Lipase (1)
JNK (1)
CETP (1)
cAMP (1)
Beta Amyloid (1)
Beta-Secretase (1)
BACE (1)
CGRP Receptor (1)
cholecystokinin (1)
DNA Alkylator/Crosslinker (1)
CSF-1R (1)
ACK (1)
Acyltransferase (1)
advanced glycation end products (1)
Anion Exchanger (1)
Aurora Kinase (1)
ATM/ATR (1)
Apoptosis (1)
Apoptosis inducer (1)
Anti-infection (1)
Antifolate (1)