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Compound Libraries Apoptosis Compound Library

Apoptosis Compound Library

Catalog No. L9000
  Library Compound List   Excel SDF

Apoptosis is a form of programmed cell death that occurs in multicellular organisms. In contrast to necrosis, which is a form of traumatic cell death that results from acute cellular injury, apoptosis is a highly regulated and controlled process that confers advantages during an organism's lifecycle. Apoptosis leads to characteristic cell changes (morphology): the cell breaks apart into multiple vesicles called apoptotic bodies, which undergo phagocytosis. Apoptosis is regulated by both pro-apoptotic (such as Fas receptor and caspases) and anti-apoptotic (such as Bcl-2 and IAP) factors. Disordered apoptosis is implicated in a variety of human diseases. Inhibition of apoptosis can result in a number of cancers, autoimmune diseases, inflammatory diseases, and viral infections. Excessive apoptosis may also be a feature of some conditions such as autoimmune diseases, neurodegenerative diseases, and ischemia-associated injury. Consequently, considerable interest has arisen in therapeutic strategies for cancer, autoimmune diseases, and neurodegenerative diseases by modulating apoptosis pharmacologically.

TargetMol’s collection of 1383 apoptosis-related compounds, Apoptosis Compound Library, is divided accordingly with compounds designed for either pro- or anti-apoptosis purposes and can be used for research in cancer and neurodegenerative diseases.

Pack Size Price/USD
100 μL * 10 mM (in DMSO) 20583.00
250 μL * 10 mM (in DMSO) 34553.00
1 mg 34553.00
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Product Description

  • A unique collection of 1383 apoptosis-related compounds for apoptosis research, research in tumorigenesis, and anti-cancer drug screening;
  • Targets include Bcl-2, Caspase, p53, TNF-alpha, and surviving, etc.;
  • Bioactivity and safety confirmed by pre-clinical research and clinical trials, and some of them are approved by FDA;
  • Detailed compound information with structure, target, activity, IC50 value, and biological activity description;
  • Structurally diverse, medicinally active, and cell permeable;
  • NMR and HPLC validated to ensure high purity and quality;

Library Customization

Targetmol Compound Libraries can be highly customized! Learn More

Packaging And Storage

  • Powder or pre-dissolved DMSO solutions in 96/384 well plate with optional 2D barcode
  • Shipped with blue ice
Request Library Compound List (L9000)

Library Composition

Apoptosis (74)
EGFR (69)
TNF (64)
JAK (50)
BCL (44)
NF-κB (44)
ERK (42)
Bcr-Abl (40)
p38 MAPK (39)
Raf (38)
Caspase (38)
VEGFR (37)
STAT (36)
CDK (36)
Src (32)
FLT (29)
HDAC (29)
PI3K (28)
PDGFR (27)
MEK (27)
COX (27)
DNA/RNA Synthesis (25)
JNK (24)
c-Kit (23)
Apoptosis inducer (23)
c-RET (22)
FGFR (22)
p53 (22)
Microtubule Associated (21)
Autophagy (21)
Akt (20)
Tyrosine Kinases (20)
Mdm2 (19)
Antioxidant (18)
Aurora Kinase (18)
Dehydrogenase (17)
IL Receptor (16)
HSP (16)
Epigenetic Reader Domain (16)
mTOR (16)
PKC (16)
HER (15)
c-Met/HGFR (13)
AChR (13)
Serine/threonin kinase (13)
Sirtuin (12)
ROS (12)
MAPK (12)
IκB/IKK (12)
GSK-3 (11)
Estrogen/progestogen Receptor (11)
Proteasome (11)
Pim (10)
PARP (10)
IGF-1R (10)
Ferroptosis (9)
AMPK (9)
DNA Alkylation (9)
DNA-PK (9)
PERK (9)
P450 (9)
PPAR (9)
RAAS (9)
TAM Receptor (9)
Tyrosinase (9)
Topoisomerase (8)
Ras (8)
HIF (8)
Histamine Receptor (7)
Histone Methyltransferase (7)
HIV Protease (7)
CaMK (7)
Antibacterial (7)
PLK (7)
PKA (7)
Trk receptor (7)
TGF-beta/Smad (7)
Syk (7)
Vitamin (7)
Retinoid Receptor (6)
PD-1/PD-L1 (6)
PDE (6)
NOS (6)
Adrenergic Receptor (6)
ATPase (6)
Casein Kinase (6)
HMG-CoA Reductase (6)
IAP (6)
Endogenous Metabolite (6)
FAK (6)
Gamma-secretase (5)
Glucocorticoid Receptor (5)
GluR (5)
Kinesin (5)
MAO (5)
MMP (5)
c-Myc (5)
Chk (5)
c-Fms (5)
Cysteine Protease (5)
BTK (5)
ALK (5)
Nrf2 (5)
NADPH (5)
MRP (5)
Phospholipase (5)
ROCK (5)
S6 Kinase (4)
Serine Protease (4)
Potassium Channel (4)
Prostaglandin Receptor (4)
Phosphatase (4)
MLK (4)
Wnt/beta-catenin (4)
TLR (4)
5-HT Receptor (4)
Antibiotic (4)
Calcium Channel (4)
Antiviral (4)
E1/E2/E3 Enzyme (4)
DUB (4)
Dopamine Receptor (4)
DNA Methyltransferase (4)
CSF-1R (4)
Lipoxygenase (4)
GR (4)
Histone Demethylase (3)
MNK (3)
GPR (3)
Hck (3)
DPP-4 (3)
ASK (3)
Beta Amyloid (3)
Antifection (3)
Amino Acids and Derivatives (3)
Survivin (3)
TRP/TRPV Channel (3)
UGT (3)
Transferase (3)
Opioid Receptor (3)
NAMPT (3)
PDK (3)
OXPHOS (3)
PAI-1 (3)
Sodium Channel (3)
SGK (2)
S1P Receptor (2)
ROR (2)
Rho (2)
RIP kinase (2)
Reductase (2)
Proton pump (2)
PTEN (2)
PAK (2)
Parasite (2)
P-gp (2)
NOD (2)
NADPH-oxidase (2)
TOPK (2)
VDA (2)
Telomerase (2)
Adenosine Receptor (2)
Androgen Receptor (2)
BACE (2)
ATM/ATR (2)
Aromatase (2)
DHFR (2)
cholecystokinin (2)
Hedgehog/Smoothened (2)
GPX (2)
Glucokinase (2)
Free radical scavengers (2)
FXR (2)
GABA Receptor (2)
Fatty Acid Synthase (2)
Mitochondrial Metabolism (2)
Liver X Receptor (2)
LRRK2 (2)
lysosomal autophagy (2)
Lipid (2)
Immunology & Inflammation related (2)
Integrin (1)
KSP (1)
LDL (1)
IDO (1)
HSV (1)
Hydrogenase (1)
LTR (1)
Mitophagy (1)
MPO (1)
Melatonin Receptor (1)
Fas/FasL (1)
Endothelin Receptor (1)
FAAH (1)
GHSR (1)
FOXO1 (1)
GST (1)
GTPase (1)
HBV (1)
HCV Protease (1)
Hippo pathway (1)
Hexokinase (1)
CRM1 (1)
CPT (1)
CFTR (1)
Chloride channel (1)
Carbonic Anhydrase (1)
DNA (1)
CXCR (1)
Deubiquitinase (1)
Dynamin (1)
ATP Citrate Lyase (1)
BMI-1 (1)
Antifungal (1)
Aminopeptidase (1)
ACAT (1)
ACK (1)
Acyltransferase (1)
Thrombin (1)
Tie-2 (1)
Wee1 (1)
MTH1 (1)
Norepinephrine (1)
Neurokinin receptor (1)
OX Receptor (1)
Nucleoside Antimetabolite/Analog (1)
NPC1L1 (1)
p97 (1)
PAFR (1)
P2 Receptor (1)
PYK2 (1)
Reverse Transcriptase (1)
PKM (1)
Sigma receptor (1)
SIK (1)