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Compound Libraries Anti-Neurodegenerative Disease Compound Library

Anti-Neurodegenerative Disease Compound Library

Catalog No. L2620
  Library Compound List   Excel SDF

Neurodegenerative disorders, such as Alzheimer’s disease (AD), Parkinson’s disease (PD), Huntington’s disease (HD), spinal muscular atrophy (SMA), and amyotrophic lateral sclerosis (ALS), are incurable and debilitating conditions characterized by progressive degeneration of specific neurons within the brains of affected individuals. Neurodegenerative diseases have become an enormous economic burden that is projected to grow significantly over the next few decades in the absence of any new therapeutic interventions.

Drugs for the central nervous system, including neurodegenerative diseases, that entered clinical development, have a considerably lower probability of reaching the marketplace (7%) than the industry average across other therapeutic areas (15%), and require a longer time for development and regulatory approval (average of 12.6 years) compared with most other diseases (e.g., 6.3 years for cardiovascular and 7.5 years for gastrointestinal indications).

In this compound library, TargetMol collects 1622 compounds related to neurodegenerative diseases having therapeutic effect or acting on neurodegenerative disease-related targets.

Pack Size Price/USD
30 μL * 10 mM (in DMSO) 11900.00
100 μL * 10 mM (in DMSO) 26300.00
250 μL * 10 mM (in DMSO) 44200.00
1 mg 44200.00
If the above compound libraries do not match your needs,
please contact our compound library specialist for a customized compound library at [email protected]
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Product Description

  • A unique collection of 1622 compounds related to neurodegenerative diseases can be used for HTS or HCS;
  • Targets include AchE, NMDA, CGRP, β -secretase, γ -secretase, Dopamine receptor, Adenosine receptor, 5-HT receptor, etc.;
  • Some of them are FDA-approved;
  • Detailed compound information with structure, target, and biological activity description;
  • NMR and HPLC/LCMS validated to ensure high purity and quality.

Library Customization

Targetmol Compound Libraries can be highly customized! Learn More

Packaging And Storage

  • Powder or pre-dissolved DMSO solutions in 96/384 well plate with optional 2D barcode
  • Shipped with blue ice
Request Library Compound List (L2620)

Library Composition

5-HT Receptor (175)
AChR (130)
Dopamine Receptor (118)
Adrenergic Receptor (101)
GABA Receptor (55)
PDE (52)
PPAR (34)
NMDAR (32)
Histamine Receptor (21)
MAO (19)
Norepinephrine (19)
JNK (18)
GluR (17)
Beta Amyloid (17)
Potassium Channel (16)
NF-κB (14)
Gamma-secretase (14)
Caspase (12)
Sodium Channel (11)
BACE (9)
Calcium Channel (9)
Adenosine Receptor (9)
P450 (9)
Cannabinoid Receptor (8)
COX (7)
Dehydrogenase (7)
Opioid Receptor (7)
Nrf2 (7)
GSK-3 (7)
Phosphatase (6)
TNF (6)
Transferase (5)
S1P Receptor (5)
Sirtuin (5)
c-Kit (5)
EGFR (5)
Endogenous Metabolite (5)
Epigenetic Reader Domain (4)
ERK (4)
Estrogen/progestogen Receptor (4)
CaMK (4)
p38 MAPK (4)
IκB/IKK (4)
MRP (4)
Lipoxygenase (3)
MMP (3)
DNA/RNA Synthesis (3)
HMG-CoA Reductase (3)
HDAC (3)
IL Receptor (3)
PKA (3)
Retinoid Receptor (3)
Carbonic Anhydrase (3)
BCL (3)
Bcr-Abl (3)
Autophagy (3)
Antioxidant (3)
BTK (3)
CCR (3)
FLT (3)
Vitamin (3)
Wnt/beta-catenin (3)
Serotonin Transporter (3)
Sigma receptor (3)
Src (3)
Trk receptor (2)
TRP/TRPV Channel (2)
UGT (2)
CSF-1R (2)
Cysteine Protease (2)
Decarboxylase (2)
Glucocorticoid Receptor (2)
Chloride channel (2)
Antiviral (2)
Aurora Kinase (2)
AChE (2)
advanced glycation end products (2)
ABC (2)
Amino Acids and Derivatives (2)
AMPK (2)
Antibacterial (2)
Antibiotic (2)
Antifection (2)
PI3K (2)
NOD (2)
Integrin (2)
GR (2)
Monoamine Transporter (2)
mTOR (2)
NADPH (2)
MT Receptor (1)
Monocarboxylate transporter (1)
Liver X Receptor (1)
Keap1-Nrf (1)
LDL (1)
MEK (1)
Microtubule Associated (1)
Mitochondrial Metabolism (1)
GRK (1)
GST (1)
Hck (1)
Histone Acetyltransferase (1)
Histone Demethylase (1)
Histone Methyltransferase (1)
HIV Protease (1)
HER (1)
HIF (1)
Hydroxylase (1)
IGF-1R (1)
iGluR (1)
NOS (1)
NPC1L1 (1)
Nucleoside Antimetabolite/Analog (1)
p53 (1)
PAFR (1)
PAI-1 (1)
PARP (1)
PDGFR (1)
PED (1)
P-gp (1)
PKC (1)
PKM (1)
Phospholipase (1)
Reverse Transcriptase (1)
Rho (1)
ROR (1)
Prostaglandin Receptor (1)
RAAS (1)
Raf (1)
Antifungal (1)
Androgen Receptor (1)
Annexin A (1)
ACAT (1)
Acyltransferase (1)
Akt (1)
ALK (1)
Aromatase (1)
ATM/ATR (1)
ATPase (1)
Beta-Secretase (1)
c-Met/HGFR (1)
CDK (1)
c-Fms (1)
CGRP Receptor (1)
FAAH (1)
Ferroptosis (1)
Glucokinase (1)
GlyT (1)
GPR (1)
Gap Junction Protein (1)
GluCls (1)
Free radical scavengers (1)
FXR (1)
DNA Alkylation (1)
VEGFR (1)
Topoisomerase (1)
Transaminase (1)
Tyrosinase (1)
Tyrosine Kinases (1)
TGF-beta/Smad (1)
Thrombin (1)
TLR (1)
S6 Kinase (1)