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Compound Libraries Anti-Breast Cancer Compound Library

Anti-Breast Cancer Compound Library

Catalog No. L2191
  Library Compound List   Excel SDF

Breast cancer is an uncontrolled growth of breast cells. Among women, breast cancer is the second most common cancer diagnosed, after skin cancer (, and the second leading cause of cancer death, after lung cancer. In recent years, incidence rates have increased slightly (by 0.3% per year).

There are several types of breast cancer, and they are broken into two main categories: noninvasive or in situ (ductal or lobular), and invasive (ductal or lobular). In addition, breast cancer can be categorized into four molecular subtypes: a “basal-like” subgroup with low estrogen receptor (ER)/progesterone receptor (PR)/human epidermal growth factor receptor 2 (HER2) and expression of basal cytokeratins (ER-PR-HER2-); a subgroup mainly driven by HER2 amplification and overexpression while being ER/PR low (ER-PR-HER2+); a luminal A group with high ER/PR and low HER2 (ER+PR+HER2-); a luminal B group with high ER/HER2 and low PR (ER+PR-HER2+). Depending on the caner’s stage and molecular type, treatment options and prognostics of breast cancers are different: a combination of surgery, radiation therapy, chemotherapy, hormone therapy and/or administration of a targeted therapy (anti-HER2) or non-HER2 targeted therapy. Several potential targets for new breast cancer drugs have been identified in recent years. Drugs based on these targets, such as kinase inhibitors (AKT), and PD-L1, are now being studied to treat triple-negative breast cancers, either by themselves, or in combination with chemotherapy.

TargetMol’s Anti-Breast Cancer Compound Library collects 1052 compounds related to breast cancer, including all reported compounds with anti-breast cancer therapeutic effect, and compounds targeting related targets in signaling pathway (HER-2, VEGF, EGFR, PARP, CDK4/6, HSP, PD-1, SET7/9, BRCA, etc.). It is a power tool for breast cancer drug discovery.

Pack Size Price/USD
100 μL * 10 mM (in DMSO) 15655.00
250 μL * 10 mM (in DMSO) 26050.00
1 mg 26050.00
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Product Description

  • A unique collection of 1052 compounds with anti-breast cancer therapeutic activity or targeting breast cancer’s major signaling pathways, can be used for anti-breast cancer drug discovery and mechanism study;
  • Targets include HER-2, VEGF, EGFR, PARP, CDK4/6, HSP, PD-1, SET7/9, BRCA, etc.;
  • Some compounds have been in market or in clinical trials;
  • Detailed compound information with structure, target, and biological activity description;
  • NMR and HPLC validated to ensure high purity and quality.

Library Customization

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Packaging And Storage

  • Powder or pre-dissolved DMSO solutions in 96/384 well plate with optional 2D barcode
  • Shipped with blue ice
Request Library Compound List (L2191)

Library Composition

PI3K (110)
EGFR (104)
VEGFR (100)
CDK (95)
COX (77)
mTOR (57)
Akt (43)
PDGFR (38)
GSK-3 (34)
AMPK (34)
HSP (32)
FGFR (30)
Estrogen/progestogen Receptor (29)
PARP (29)
TGF-beta/Smad (29)
DNA-PK (28)
c-Kit (25)
Src (25)
HER (24)
ATM/ATR (21)
S6 Kinase (21)
FLT (20)
Autophagy (19)
Wnt/beta-catenin (19)
ERK (17)
DNA/RNA Synthesis (16)
c-Met/HGFR (15)
JAK (15)
NF-κB (14)
Bcr-Abl (14)
Apoptosis (14)
Topoisomerase (14)
Gamma-secretase (13)
HDAC (13)
MEK (12)
PKC (12)
Raf (11)
STAT (11)
c-RET (11)
Antioxidant (10)
Potassium Channel (9)
TNF (8)
Tyrosine Kinases (8)
Aromatase (8)
Microtubule Associated (8)
p38 MAPK (8)
PDK (7)
Hedgehog/Smoothened (7)
IGF-1R (7)
Aurora Kinase (7)
Casein Kinase (7)
Caspase (7)
ALK (7)
Trk receptor (7)
PKA (7)
TAM Receptor (7)
Epigenetic Reader Domain (6)
PD-1/PD-L1 (5)
P450 (5)
IL Receptor (5)
Adrenergic Receptor (5)
Androgen Receptor (5)
BTK (5)
c-Fms (5)
Chk (5)
ROCK (5)
PPAR (4)
Dehydrogenase (4)
Glucocorticoid Receptor (4)
Estrogen Receptor/ERR (4)
FAK (4)
BCL (4)
Apoptosis inducer (4)
Integrin (4)
Lipoxygenase (4)
NADPH (4)
MMP (4)
MPO (3)
MRP (3)
NOS (3)
MLK (3)
PDE (3)
JNK (3)
IκB/IKK (3)
HSV (3)
IAP (3)
Histone Methyltransferase (3)
Antibacterial (3)
5-HT Receptor (3)
Beta Amyloid (3)
Carbonic Anhydrase (3)
Glucokinase (3)
GABA Receptor (3)
CSF-1R (3)
CXCR (3)
Prostaglandin Receptor (3)
PLK (3)
Sirtuin (3)
ROS (3)
S1P Receptor (3)
Serine/threonin kinase (3)
SGK (3)
transporter (3)
Tie-2 (3)
TOPK (2)
Syk (2)
Tyrosinase (2)
SIK (2)
PYK2 (2)
Serine Protease (2)
Sodium Channel (2)
Porcupine (2)
Phospholipase (2)
DHFR (2)
DNA Alkylation (2)
Fatty Acid Synthase (2)
Endogenous Metabolite (2)
Ephrin Receptor (2)
Calcium Channel (2)
CaMK (2)
BACE (2)
Antifungal (2)
ATPase (2)
AChR (2)
Antiviral (2)
Histamine Receptor (2)
Histone Demethylase (2)
HIF (2)
Hck (2)
HCV Protease (2)
GPR (2)
GR (2)
IDO (2)
LDL (2)
LRRK2 (2)
PI4K (2)
P-gp (2)
p53 (2)
MELK (2)
MAO (2)
MAPK (2)
Mdm2 (2)
Melatonin Receptor (1)
Nrf2 (1)
Nucleoside Antimetabolite/Analog (1)
Opioid Receptor (1)
MNK (1)
Parasite (1)
P2 Receptor (1)
Phosphatase (1)
Pim (1)
lysosomal autophagy (1)
Liver X Receptor (1)
Lipase (1)
KSP (1)
Immunology & Inflammation related (1)
GTPase (1)
HIF/HIF Prolyl-Hydroxylase (1)
Hexokinase (1)
HIV Protease (1)
Antifection (1)
Adenosine Receptor (1)
ABC (1)
AhR (1)
BCRP (1)
FAAH (1)
Gap Junction Protein (1)
GluR (1)
GNRH Receptor (1)
Dopamine Receptor (1)
DUB (1)
Discoidin Domain Receptor (DDR) (1)
Cysteine Protease (1)
cholecystokinin (1)
cell cycle arrest (1)
Platelet aggregation (1)
PTEN (1)
ROR (1)
Ras (1)
Reactive Oxygen Species (1)
Retinoid Receptor (1)
Rho (1)
Telomerase (1)
stilbene oxidase (1)
STING (1)
Survivin (1)
Salt-Inducible Kinase (1)
Wee1 (1)
Wnk (1)
TLR (1)
TRP/TRPV Channel (1)