Cart
Compound Libraries ACE2-Targeted compound library (CADD)

ACE2-Targeted compound library (CADD)

Catalog No. L1713
  Library Compound List   Excel SDF

The host ACE2 has been proved by many studies to be the specific receptor for the Spike RBD of SARS-CoV12. The latest research shows that the host receptor of SARS-CoV-2 is consistent with SARS-CoV, exhibiting that the Spike RBD sequence of SARS-CoV-2 is similar to SARS-CoV RBD and there are important interactions between several key amino acid residues of RBD receptor-binding motif and ACE2. Based on the current research progress, ACE2 is considered as a host target for the treatment of coronavirus infection to block SARS-CoV-2 from entering host cells. 

By binding with ACE2, small molecules have the potential to disrupt the interaction of ACE2 with RBD. Based on the protein structure of human ACE2, we selected 462 top-ranked docked molecules into ACE2-Targeted compound library (CADD) by molecular docking virtual screening against 15,376 compound structures. To speed up the research and development of anti-SARS-CoV-2 drugs, we provide the virtual screening result for free!

Pack Size Price/USD
100 μL * 10 mM (in DMSO) 6600.00
Request Library
Get quote

Product Description

  • A unique collection of 462 compounds having the potential of anti-SARS-CoV-2 activity, can be used for high throughput screening and high content screening;
  • Top-ranked docked compounds targeting human ACE2 will improve the hit success rate;
  • Detailed compound information with structure, target, and biological activity description;
  • NMR and HPLC validated to ensure high purity and quality.

Library Customization

Targetmol Compound Libraries can be highly customized! Learn More

Packaging And Storage

  • Powder or pre-dissolved DMSO solutions in 96/384 well plate with optional 2D barcode
  • Shipped with blue ice
Request Library Compound List (L1713)

Library Composition

HEK293 (20)
Beta-lactamase AmpC (19)
Prelamin-A/C (16)
Mothers against decapentaplegic homolog 3 (14)
Plasmodium falciparum (13)
Thyroid hormone receptor beta-1 (13)
Antioxidant (13)
Cellular tumor antigen p53 (11)
Nuclear factor erythroid 2-related factor 2 (10)
Histone Methyltransferase (9)
Antibacterial (9)
Adrenergic Receptor (8)
Geminin (8)
Guanine nucleotide-binding protein G(s), subunit alpha (8)
DNA/RNA Synthesis (7)
Ataxin-2 (7)
Microtubule-associated protein tau (7)
Nuclear receptor ROR-gamma (6)
Nonstructural protein 1 (6)
Prostaglandin Receptor (6)
Ataxin (6)
Glucagon-like peptide 1 receptor (5)
Glycoprotein hormones alpha chain (5)
Epigenetic Reader Domain (5)
Calcium Channel (5)
TAR DNA-binding protein 43 (5)
Histone Acetyltransferase (5)
HIV Protease (5)
HMG-CoA Reductase (4)
Sodium Channel (4)
Potassium Channel (4)
RAAS (4)
PKC (3)
Short transient receptor potential channel 4 (3)
Inositol monophosphatase 1 (3)
HDAC (3)
P450 (3)
PDE (3)
Autophagy (3)
BCL (3)
Bcr-Abl (3)
Antibiotic (3)
Akt (3)
Aldehyde dehydrogenase 1A1 (3)
AChR (3)
DNA polymerase iota (3)
Caspase (3)
VEGFR (3)
Vitamin (3)
Tyrosinase (2)
Thrombin (2)
CCR (2)
DNA dC->dU-editing enzyme APOBEC-3F (2)
Dopamine Receptor (2)
c-RET (2)
Cruzipain (2)
ERK (2)
Estrogen/progestogen Receptor (2)
FGFR (2)
FK506 binding protein 12 (2)
FLT (2)
Aberrant vpr protein (2)
ATPase family AAA domain-containing protein 5 (2)
c-Kit (2)
OX Receptor (2)
P2 Receptor (2)
NOS (2)
Opioid Receptor (2)
mTOR (2)
Endogenous Metabolite (2)
microRNA 21 (2)
MMP (2)
JAK (2)
Sirtuin (2)
SGLT (2)
Survival motor neuron protein (2)
Topoisomerase (2)
Reverse Transcriptase (2)
ribosome (2)
NF-κB (2)
PI3K (2)
Protease-activated Receptor (1)
Prostaglandin E synthase (1)
ROS (1)
S1P Receptor (1)
Raf (1)
RAR/RXR (1)
Reductase (1)
Transferase (1)
Trk receptor (1)
TLR (1)
TNF (1)
TAM Receptor (1)
Thioredoxin glutathione reductase (1)
Src (1)
STAT (1)
Stemness kinase (1)
Lipoxygenase (1)
MEK (1)
Histone-lysine N-methyltransferase, H3 lysine-9 specific 3 (1)
HepG2 (1)
HER (1)
Integrin (1)
NADPH (1)
MRP (1)
P2X Receptor (1)
PDK (1)
Phosphorylase (1)
p53 (1)
PAI-1 (1)
c-Met/HGFR (1)
COX (1)
Cannabinoid Receptor (1)
Bradykinin Receptor (1)
ATP-dependent DNA helicase Q1 (1)
ATP-dependent molecular chaperone HSP82 (1)
Aurora Kinase (1)
Beta-glucocerebrosidase (1)
Acetyl-CoA Carboxylase (1)
Adenosine Receptor (1)
Androgen Receptor (1)
Antifolate (1)
ATP Citrate Lyase (1)
Apoptosis (1)
Apoptosis inducer (1)
Aromatase (1)
Gamma-secretase (1)
FAD-linked sulfhydryl oxidase ALR (1)
Fatty Acid Synthase (1)
Ferroptosis (1)
Glutathione reductase (1)
GPR (1)
GTPase (1)
HCV Protease (1)
CSF-1R (1)
CXCR (1)
Cytochrome P450 1A2 (1)
Dehydrogenase (1)
DHFR (1)
Discoidin Domain Receptor (DDR) (1)
E1/E2/E3 Enzyme (1)
EGFR (1)
DNA polymerase eta (1)
CDK (1)
Vasopressin Receptor (1)
Voltage-gated T-type calcium channel alpha-1H subunit (1)
Wnt/beta-catenin (1)