sales@targetmol.com (US) / info@targetmol.com    Tel: (781) 999-4286 / (781) 999-5354
Home > JAK/STAT signaling > EGFR > TAK-285
TAK-285  
Catalog No. T6039    CAS 871026-44-7
Pack Size
Availability
Price/USD
Quantity
5mg
Inquiry
187.00
10mg
Inquiry
340.00
25mg
Inquiry
590.00
50mg
Inquiry
1063.00
1g
Get quote
0.00
5g
Get quote
0.00
10mM * 1mL (in DMSO)
Inquiry
225.00
Bulk Size: Please Quote for Discount
Documents and Quality Management
Purity:98.00% COA Datasheet
Biological Activity:

Product Description:

TAK-285 is a novel dual HER2 and EGFR(HER1) inhibitor with IC50 of 17 nM and 23 nM, >10-fold selectivity for HER1/2 than HER4, less potent to MEK1/5, c-Met, Aurora B, Lck, CSK etc. Phase 1.

Target:
MEK1; HER4; HER2; EGFR/HER1; AuroraB;
Research Area:
Cancer
Chemical Information:
Molecular Weight 547.96
Formula C26H25ClF3N5O3
CAS Number 871026-44-7
Solubility DMSO:102 mg/mL (186.1 mM);Ethanol:50 mg/mL (91.2 mM);Water:<1 mg/mL
Storage 3 years -20°C powder;
2 years -80°C in solvent;
Remark For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ℃ for several month.
Technical Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store Products, and issues that need special attention for cell-based assays and animal experiments.

Related Compound Libraries
This product is contained In the following compound libraries:
  • The compound is not included in our libraries at this moment.
Product Recommendations
  • PD168393, PD168393 is an irreversible EGFR inhibitor (IC50: 0.70 nM), irreversibly alkylate Cys-773; inactive ...
  • Olmutinib (HM61713, BI 1482694), Olmutinib is an orally available small molecule, a mutant-selective inhibitor of epidermal growth fa...
  • NSC228155, NSC228155 is an activator of EGFR, binding to the sEGFR dimerization domain II and modulate EGFR tyr...
  • EAI045, EAI045, an allosteric inhibitor, targets towards drug-resistant EGFR mutants but avoids the wild-typ...
  • WZ3146, WZ3146 is a mutant-selective irreversible inhibitor of EGFR(L858R) and EGFR(E746_A750) with IC50 of ...

 

Reference

If you have additional questions, Please send us a message. * Required